Molecular and clinical follow-up after treatment of multiple myeloma.

abstract：:A hairy-cell leukaemia (HCL) cell line, HCL-O, was established from the peripheral blood of a 62-year-old Japanese patient with a unique variant of HCL strongly expressing CD21, the receptor for the Epstein-Barr virus (EBV). The HCL-O cells expressed antigens similar and dissimilar to those expressed with the original...

journal_title：Acta haematologica

authors： Tokioka T,Shimamoto Y,Nagumo F,Tadano J,Yamaguchi M

更新日期：1994-01-01 00:00:00

abstract：:Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative myeloproliferative neoplasms. Preclinical results support that JAK2 inhibitors could show efficacy in treating chronic myeloproliferative neopla...

journal_title：Acta haematologica

authors： Ringel F,Kaeda J,Schwarz M,Oberender C,Grille P,Dörken B,Marque F,Manley PW,Radimerski T,le Coutre P

更新日期：2014-01-01 00:00:00

abstract：:A patient with regional enteritis had received iron dextran for treatment of iron deficiency. Subsequently he developed a large (3.1 g/100 ml) IgG-K serum spike which had precipitin activity against dextran sulfate but not a variety of other antigens. There has been no evidence of multiple myeloma and the spike gradua...

journal_title：Acta haematologica

authors： Shimm DS,Cohen HJ

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Posterior reversible encephalopathy syndrome (PRES) is a rare but serious complication after allogeneic hematopoietic stem cell transplantation (alloHSCT). Among others, calcineurin inhibitors (CNI) for prophylaxis of graft-versus-host disease (GvHD) may promote the development of PRES, but the pathomechanis...

journal_title：Acta haematologica

authors： Schmidt V,Prell T,Treschl A,Klink A,Hochhaus A,Sayer HG

更新日期：2016-01-01 00:00:00

abstract：:Sera from 154 hemophiliacs, including 132 with hemophilia A and 22 with hemophilia B, were examined for antibodies against human T cell lymphotropic virus type III (HTLV-III) and type I by strip radioimmunoassay based on the Western blotting technique. Sixty-two patients lived in Kyushu, a known endemic area of HTLV-I...

journal_title：Acta haematologica

authors： Hattori T,Ikematsu S,Chosa T,Yamamoto S,Matsuoka M,Fukutake K,Robert-Guroff M,Takatsuki K

更新日期：1987-01-01 00:00:00

abstract：:Neurologic complications of allogeneic hematopoietic cell transplantation (allo-HCT) include infections, cerebrovascular events, therapy-induced neurotoxicity, recurrent malignancies, and neurologic manifestations of graft-versus-host disease (GVHD). Anti-glutamic acid decarboxylase (GAD) antibody-associated cerebella...

journal_title：Acta haematologica

authors： Shargian-Alon L,Raanani P,Rozovski U,Siegal T,Yust-Katz S,Yeshurun M

更新日期：2019-01-01 00:00:00

abstract：:Primary plasma cell leukemia (PCL) is a rare form of plasma cell neoplasm with a poor prognosis. Conventional melphalan-based treatments have been most disappointing. We report the case of a 62-year-old man with a primary form of PCL treated with VAD combination achieving an objective response, and who received high-d...

journal_title：Acta haematologica

authors： Panizo C,Rifón J,Rodríguez-Wilhelmi P,Cuesta B,Rocha E

更新日期：1999-01-01 00:00:00

abstract：:Haemoglobin synthesis was studied in bone marrow erythroblasts and in reticulocytes of 4 children with beta O-thalassaemia major and of 7 children with beta +-thalassaemia major. In patients with beta O-thalassaemia the gamma/a ratio was found to be lower in bone marrow than in peripheral blood. On the contrary, in pa...

journal_title：Acta haematologica

authors： Musumeci S,Schilirò G,Romeo MA,Pizzarelli G,Fischer A,Russo G

更新日期：1981-01-01 00:00:00

abstract：:Contamination of autologous graft by tumor, in addition to incomplete tumor eradication, can partly explain why relapse remains the commonest cause of treatment failure after autologous stem cell transplantation (ASCT) in patients with malignant hematologic disorders. Monitoring of minimal residual disease (MRD) is no...

journal_title：Acta haematologica

authors： Melillo L,Cascavilla N,Lerma E,Corsetti MT,Carella AM

更新日期：2005-01-01 00:00:00

abstract：:In order to study the abnormal differentiation and proliferation of precursor T cells in homosexual men, a study was made of T-cell colony formation in 15 healthy homosexual men without anti-human immunodeficiency virus (HIV) antibody. The colony forming method used was the one-step monolayer technique using phytohema...

journal_title：Acta haematologica

authors： Wakabayashi Y,Sugimoto M,Ishiyama T,Hashimoto M,Horie S,Hirose S

更新日期：1989-01-01 00:00:00

abstract：:The dilution in the circulating blood of lymphocytes lablled in vitro with 3H-cytidine was examined after autotransfusion in 9 patients with Hodgkin's disease (HD) stage II A-IV B, 5 of whom were untreated; in 2 untreated patients with carcinoma, and in 1 treated patient with scleroderma. The blood transit time of exc...

journal_title：Acta haematologica

authors： Schick P,Trepel F,Eder M,Matzner M,Benedek S,Theml H,Kaboth W,Begemann H,Fliedner TM

更新日期：1975-01-01 00:00:00

abstract：:We present the case of a woman undergoing treatment with acenocoumarol for deep vein thrombosis, who maintained an international normalized ratio (INR) of between 2.5 and 4 for 2 months. Seven days after the introduction of amoxycillin (500 mg/8 h) for a probable respiratory infection, the patient developed spontaneou...

journal_title：Acta haematologica

authors： Soto J,Sacristan JA,Alsar MJ,Fernandez-Viadero C,Verduga R

更新日期：1993-01-01 00:00:00

abstract：:Low-dose cytosine arabinoside (ARA-C) induced complete remissions in 6 of 10 patients with acute non-lymphocytic leukaemia (ANLL) who were either refractory to combination chemotherapy with anthracyclines and conventional doses of ARA-C, or were in relapse. Three patients relapsed after 4, 19, and 20 months, whereas 3...

journal_title：Acta haematologica

authors： Krogh Jensen M,Stentoft J

更新日期：1986-01-01 00:00:00

abstract：:Serum soluble interleukin-6 receptor (sIL-6R) concentrations were measured in 50 patients with plasma cell dyscrasias using a commercially available immunoenzymatic assay kit. There were 40 patients with multiple myeloma (MM), 5 patients with monoclonal gammopathy of undetermined significance (MGUS), 3 patients with s...

journal_title：Acta haematologica

authors： Papadaki H,Kyriakou D,Foudoulakis A,Markidou F,Alexandrakis M,Eliopoulos GD

更新日期：1997-01-01 00:00:00

abstract：:Thymoma is an uncommon neoplasia derived from the epithelial cells of the thymus, which leads to immune dysregulation and is associated with a series of autoimmune diseases. However, the concurrence of these disease entities is rare, and the exact mechanisms of these diseases are still unclear. We have admitted severa...

journal_title：Acta haematologica

authors： Wang W,Chen LY,Zhao W,Ren Y,Wang L,Li X,Jiang Y,Gao H

更新日期：2020-01-01 00:00:00

abstract：:Of 34 patients with chronic inflammatory bowel disease (CIBD), 4 developed well-documented episodes of deep-venous thrombosis. All 4 patients had active disease at the time of thrombosis. This group was studied to determine if the tendency to deep-venous thrombosis in patients with CIBD was associated with reduced ant...

journal_title：Acta haematologica

authors： Ghosh S,Mackie MJ,McVerry BA,Galloway M,Ellis A,McKay J

更新日期：1983-01-01 00:00:00

abstract：:Coagulation factor VIII inhibitor arising in a patient with autoimmune disease was immunologically analyzed. A 63-year-old man who had been diagnosed as suffering from polyarteritis nodosa was treated with prednisolone for 10 years. Severe bleeding tendency developed and coagulation studies demonstrated a high titer o...

journal_title：Acta haematologica

authors： Okamura T,Yamauchi Y,Fukuda T,Suehiro K,Murakawa M,Shibuya T,Nagasawa K,Harada M,Niho Y

更新日期：1991-01-01 00:00:00

abstract：:Two subjects, not previously reported in detail, had severe inherited deficiencies of erythrocyte pyrimidine nucleotidase. This was manifested hematologically by moderate hemolytic anemia with splenomegaly, morphologically by punctate basophilic stippling of Wright's stained erythrocytes, and biochemically by intraery...

journal_title：Acta haematologica

authors： Paglia DE,Fink K,Valentine WN

更新日期：1980-01-01 00:00:00

abstract：:Although multiple myeloma (MM) remains an incurable disease, its treatment has improved over the past decade. This improvement has been at least in part due to the introduction of novel antimyeloma agents with new mechanisms of action, including those that target both myeloma cells and the tumor microenvironment, with...

journal_title：Acta haematologica

authors： Cibeira MT,Mercadal S,Arenillas L,Muntañola A,Salamero O,Bladé J

更新日期：2006-01-01 00:00:00

abstract：:The increased longevity of patients with thalassemia and sickle cell disease (SCD) introduces new clinical challenges due to the accumulation of disease-related morbidity, psychosocial issues and health care adjustments. Patients with thalassemia major now live into adulthood without suffering heart failure but must c...

journal_title：Acta haematologica

authors： Yacobovich J,Tamary H

更新日期：2014-01-01 00:00:00

abstract：:Macrothrombocytopenia (MTP) is a group of rare disorders characterized by giant platelets, thrombocytopenia, and variable association with abnormal bleeding. Inherited MTP are frequently misdiagnosed as immune thrombocytopenia. Associated second-organ manifestation can help narrow down syndromic MTPs. We describe a ca...

journal_title：Acta haematologica

authors： Karki NR,Ajebo G,Savage N,Kutlar A

更新日期：2021-01-01 00:00:00

abstract：:In pregnant mice. 55Fe-labeled iron-dextran (Imferon) is transferred across the placenta. It was detected in the bone marrow, liver, spleen and peripheral blood of the pregnant animal, as well as in the embryonic liver erythroid precursors and peripheral blood. Uptake by liver and peripheral blood cells of pregnant an...

journal_title：Acta haematologica

authors： Djaldetti M,Notti I,Fishman P,Bessler H

更新日期：1975-01-01 00:00:00

abstract：:A 67-year-old woman with agnogenic myeloid metaplasia, who underwent splenectomy 1 year after the diagnosis, experienced spontaneous hematologic remission 6 years after splenectomy. Ten months before her anemia improved, peripheral leukocytes no longer showed a shift to the left and peripheral erythroblasts had disapp...

journal_title：Acta haematologica

authors： Shimizu K,Hotta T

更新日期：1990-01-01 00:00:00

abstract：:Immunoglobulin light chain amyloidosis (AL amyloidosis) is a rare, life-threatening disease characterized by the deposition of misfolded proteins in vital organs such as the heart, the lungs, the kidneys, the peripheral nervous system, and the gastrointestinal tract. This causes a direct toxic effect, eventually leadi...

journal_title：Acta haematologica

authors： Van Doren L,Lentzsch S

更新日期：2020-01-01 00:00:00

abstract：:Using labelled erythrocytes and human serum albumin, the volume of circulating erythrocytes and plasma was determined in the spleen and individual parts of the skeleton of mice under physiological conditions and 48 h after X-irradiation with a dose of 2,87 Gy. The results are significant for the interpretation of the ...

journal_title：Acta haematologica

authors： Vácha J,Holá J,Dungel J,Znojil V

更新日期：1980-01-01 00:00:00

abstract：:The fibrinolytic response to surgical trauma was studied longitudinally in 7 pigs by measuring the fibrinolytic activity in the blood and vein wall simultaneously. The results indicated a marked suppression in fibrinolytic activity in the blood which was closely correlated with the activity in the vein wall. This corr...

journal_title：Acta haematologica

authors： Wu AV,Mansfield AO

更新日期：1980-01-01 00:00:00

abstract：:Increased levels of hemoglobin A(2) (HbA(2)) are present in most beta-thalassemia carriers. The mechanism of this effect is not understood, although the increase may result from transcriptional and posttranscriptional changes. In the present study, we quantitate delta-globin mRNA levels in peripheral-blood-enriched re...

journal_title：Acta haematologica

authors： Huang SZ,Zeng FY,Chen MJ,Ren ZR,Shen M,Rodgers GP,Schechter AN,Zeng YT

更新日期：1999-01-01 00:00:00

abstract：:Basic fibroblast growth factor (b-FGF) mediates a variety of biological responses such as angiogenesis and hematopoiesis. We examined the effect of b-FGF on human neutrophil functions in vitro. The surface expression of effector cell molecules on neutrophils was determined by flow cytometry and monoclonal antibodies. ...

journal_title：Acta haematologica

authors： Takagi S,Takahashi K,Katsura Y,Matsuoka T,Ohsaka A

更新日期：2000-01-01 00:00:00

abstract：:An ultrastructural study of the aspirated bone marrow of a patient with congenital dyserythropoietic anemia type I is presented. Both in transmission electron microscopy (TEM) and in scanning electron microscopy (SEM) ultrastructural abnormalities of the bone marrow erythroid precursors were seen. These abnormalities ...

journal_title：Acta haematologica

authors： Conde E,Mazo E,Baro J,Lafarga M,Cuadrado MA,Recio M,Zubizarreta A

更新日期：1983-01-01 00:00:00

abstract：:Pyruvate kinase (PK) from four patients with moderate to severe congenital non-spherocytic haemolytic anaemia was characterized by methods recommended by the ICSH. The possibility that two of the patients are true homozygotes cannot be ruled out, while the other two apparently represent double heterozygotes. All but o...

journal_title：Acta haematologica

authors： Tegos C,Anagnostoulis G

更新日期：1994-01-01 00:00:00