Low-dose cytosine arabinoside in the treatment of relapsed and refractory acute non-lymphocytic leukaemia.

abstract：:It has been proposed that iron overload may adversely affect liver disease outcome. The recent identification of 2 mutations in the HFE gene related to hereditary haemochromatosis (Cys282Tyr and His63Asp) provided an opportunity to test whether they are associated with hepatic iron accumulation and the activity and se...

journal_title：Acta haematologica

authors： Martinelli AL,Franco RF,Villanova MG,Figueiredo JF,Secaf M,Tavella MH,Ramalho LN,Zucoloto S,Zago MA

更新日期：2000-01-01 00:00:00

abstract：:Amylase-producing tumors are mainly adenocarcinomas and, in rare instances, multiple myelomas. We describe here a first case of amylase-producing Bence Jones type myeloma with pancreatitis-like symptoms and the second in a Caucasian patient. The finding of salivary-type hyperamylasemia in a 72-year-old female with a p...

journal_title：Acta haematologica

authors： Lopez J,Ulibarrena C,Gonzalez-Porque P,Navas G,Roldan E,Cancelas JA,Perez-Oteyza J,Burgaleta C,García-Laraña J,Sastre JL

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The treatment of relapsed/refractory (R/R) peripheral T cell lymphoma (PTCL) is limited to a few agents. Romidepsin, a histone deacetylase inhibitor, was approved for PTCL treatment as a single agent in the R/R setting, yet with partial efficacy. Several attempts to combine romidepsin with other chemotherapy...

journal_title：Acta haematologica

authors： Nachmias B,Shaulov A,Lavie D,Goldschmidt N,Gural A,Saban R,Lebel E,Gatt ME

更新日期：2019-01-01 00:00:00

abstract：:Treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute leukemia (Ph+ ALL) has been revolutionized with the advent of tyrosine kinase inhibitors (TKIs). Most patients with CML achieve long-term survival similar to individuals without CML due to treatment with TKIs not only in frontline b...

journal_title：Acta haematologica

authors： Saussele S,Haverkamp W,Lang F,Koschmieder S,Kiani A,Jentsch-Ullrich K,Stegelmann F,Pfeifer H,La Rosée P,Goekbuget N,Rieger C,Waller CF,Franke GN,le Coutre P,Kirchmair R,Junghanss C

更新日期：2020-01-01 00:00:00

abstract：:In the diagnosis of multiple myeloma (MM), the radiological skeletal survey (RSS) was proven to be most useful for the detection of bone lesions. Since 1961, a new technique radioisotopic bone scan (RIBS), for the detection of such lesions, using 85Sr and 99mTc, has been shown to be highly sensitive for the detection ...

journal_title：Acta haematologica

authors： Tamir R,Glanz I,Lubin E,Vana D,Pick AI

更新日期：1983-01-01 00:00:00

abstract：:A case of lymphoma presenting with features shared by hairy cell leukemia (HCL) and its variant, intermediate lymphocytic lymphoma (ILL) and monocytoid B-cell lymphoma (MBCL) is described. Clinical presentation and the morphological findings observed in peripheral blood and in bone marrow biopsy suggested an HCL; howe...

journal_title：Acta haematologica

authors： Adami F,Chilosi M,Lestani M,Scarpa A,Zambello R,Pomponi F,Semenzato G,Menestrina F

更新日期：1993-01-01 00:00:00

abstract：:Allogeneic stem cell transplantation (SCT) is the treatment of choice for selected patients with chronic myeloid leukemia (CML). However, it is associated with a high risk of treatment-related mortality (TRM) and morbidity. To assist in decision making about transplantation, a simple scoring system to assess the risk ...

journal_title：Acta haematologica

authors： Qazilbash MH,Devetten MP,Abraham J,Lynch JP,Beall CL,Weisenborn R,Bunner P,Ericson SG

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:In 2003, oral fludarabine was introduced in the USA for the treatment of patients with hematologic malignancies as an alternative to its intravenous (i.v.) formulation; in 2008, it was introduced in México while the i.v. formulation was withdrawn. Accordingly, i.v. fludarabine had to be replaced by oral flud...

journal_title：Acta haematologica

authors： Velázquez-Sánchez-de-Cima S,Zamora-Ortiz G,Hernández-Reyes J,Rosales-Durón AD,González-Ramírez MP,Martagón-Herrera NA,Ruiz-Delgado GJ,Ruiz-Argüelles GJ

更新日期：2014-01-01 00:00:00

abstract：:Among the 193 patients (82 female, 111 male) treated primarily for Hodgkin's disease at our clinic between 1990 and 2001 and followed up until 2003, 42 (22%) had mediastinal bulky tumours (MBTs) by the Cotswolds criteria. The rate of MBT diagnosis was significantly greater in the early stage of the disease, these pati...

journal_title：Acta haematologica

authors： Keresztes K,Lengyel Z,Devenyi K,Vadasz G,Miltenyi Z,Illes A

更新日期：2004-01-01 00:00:00

abstract：:We describe a B cell chronic lymphocytic leukemia/lymphoma (B-CLL) patient with an adrenocortical adenoma. He was treated initially with oral cyclophosphamide and prednisolone for 2 months, followed by low-dose prednisolone for an additional 2 years, which resulted in the prompt disappearance of CLL cells. After a per...

journal_title：Acta haematologica

authors： Adachi Y,Adachi M,Hinoda Y,Fukushima H,Takahashi T,Imai K

更新日期：1997-01-01 00:00:00

abstract：:We examined the in vivo effect of granulocyte colony-stimulating factor (G-CSF) on the surface expression of putative counterligands for endothelial selectins on neutrophils in healthy volunteers. G-CSF (50 microg/m2/day) was administered subcutaneously to 5 healthy volunteers for 4 days. The expression of surface ant...

journal_title：Acta haematologica

authors： Ohsaka A,Saionji K

更新日期：1998-01-01 00:00:00

abstract：:The presence of the sickle cell (Hb S) gene in Saudi Arabia was first reported by Lehmann et al. in 1963 [Nature 198, pp. 492-493]. Later, Hb S, alpha- and beta-thalassaemia, glucose-6-phosphate dehydrogenase deficiency and other enzymopathies were shown to occur at a variable prevalence in different regions of the co...

journal_title：Acta haematologica

authors： el-Hazmi MA

更新日期：1987-01-01 00:00:00

abstract：:The distribution of thymus-dependent (T cells) and bone marrow-derived lymphocytes (B cells) was studied in 74 patients with Hodgkin's disease and 33 normal controls. A T cell deficit was found in untreated patients as well as in long-term survivors in remission. Therapy slightly enhanced the T cell depletion in Hodgk...

journal_title：Acta haematologica

authors： Many A,Biniaminov M,Rosenthal E,Aghai E,Ramot B

更新日期：1976-01-01 00:00:00

abstract：:The clinical pattern of haemolysis associated with Donath-Landsteiner antibodies has undergone a change over the years. In the current study 13 patients developed the acute form of the disease whilst only 1 presented with the classical picture of chronic paroxysmal cold haemoglobinuria. The acute illness typically occ...

journal_title：Acta haematologica

authors： Sokol RJ,Hewitt S,Stamps BK

更新日期：1982-01-01 00:00:00

abstract：:Immunologic abnormalities have been described in patients with Hodgkin lymphoma, including autoimmune hemolytic anemia and immune thrombocytopenic purpura. The concurrent diagnoses of Hodgkin lymphoma and acquired aplastic anemia, however, is extremely rare. We report a 56-year-old Japanese female patient with severe ...

journal_title：Acta haematologica

authors： Saitoh T,Matsushima T,Yamane A,Sakuraya M,Irisawa H,Yokohama A,Handa H,Tsukamoto N,Karasawa M,Nojima Y,Murakami H

更新日期：2007-01-01 00:00:00

abstract：:A 16-year-old Japanese woman with acute myelogenous leukemia (AML) and t(6;9) received peripheral blood stem cell transplantation (PBSCT). Although chromosomal studies just prior to and following PBSCT showed a normal karyotype, reverse transcription-polymerase chain reaction (RT-PCR) detected the mRNA derived from th...

journal_title：Acta haematologica

authors： Nakano H,Shimamoto Y,Suga K,Kobayashi M

更新日期：1995-01-01 00:00:00

abstract：:The fibrinolytic response to surgical trauma was studied longitudinally in 7 pigs by measuring the fibrinolytic activity in the blood and vein wall simultaneously. The results indicated a marked suppression in fibrinolytic activity in the blood which was closely correlated with the activity in the vein wall. This corr...

journal_title：Acta haematologica

authors： Wu AV,Mansfield AO

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Biphenotypic acute leukemia (BAL) is a rare type of acute leukemia that presents with a high degree of heterogeneity and is not well defined. METHODS:We identified 51 cases (3%) of BAL from 1,693 newly diagnosed acute leukemia patients according to the EGIL scoring system. The immunophenotyping, cytogenetic...

journal_title：Acta haematologica

authors： Zhang Y,Wu D,Sun A,Qiu H,He G,Jin Z,Tang X,Miao M,Fu Z,Han Y

更新日期：2011-01-01 00:00:00

abstract：:In a dose titration study we tested the efficacy and tolerance of recombinant human erythropoietin (rhEPO) in 10 patients with myelodysplasia (MDS) and 2 patients with idiopathic myelofibrosis. Patients with a haemoglobin level < 100 g/l were treated as out-patients for 12 weeks with daily doses ranging from 30 U/kg b...

journal_title：Acta haematologica

authors： Mohr B,Herrmann R,Huhn D

更新日期：1993-01-01 00:00:00

abstract：:Bone marrow fragments from 10 patients with a megaloblastic anaemia due to vitamin B12 or folate deficiency were studied by electron microscopy and electron microscope autoradiography. A proportion of the erythroblasts showed ultrastructural abnormalities. Some of the cells containing autophagic vacuoles, large sidero...

journal_title：Acta haematologica

authors： Wickramasinghe SN,Bush V

更新日期：1977-01-01 00:00:00

abstract：:Total and unsaturated folate binding capacity (TFBC, UFBC) have been measured in sera of selective groups of patients to study the role of cell turnover, cell necrosis and the effect of pregnancy in determining their concentrations in blood. The mean value of TFBC in 35 normal sera was 151 +/- (SD) 53 pg/ml with a sat...

journal_title：Acta haematologica

authors： Corrocher R,Bambara LM,Pachor ML,Biasi D,Stanzial A,De Sandre G

更新日期：1979-01-01 00:00:00

abstract：:Bone marrow samples of 28 individuals with clinically benign and of 41 patients with malignant monoclonal gammopathy were analyzed for the total number of lymphoplasmocellular elements containing cytoplasmic immunoglobulins and for the monoclonal fraction of these cells. Monoclonal immunoglobulin components were deter...

journal_title：Acta haematologica

authors： Morell A,Maurer W,Skvaril F,Barandun S

更新日期：1978-01-01 00:00:00

abstract：:The increased incidence of parallel tubular structures in lymphocytes of patients with Hodgkin's disease was investigated for a correlation with either impairment of cellular immunity (measured by DNCB-skin test and PHA-induced lymphocyte stimulation in vitro) or an increase of antibodies against cytomegalovirus or Ep...

journal_title：Acta haematologica

authors： Halie MR,Langenhuysen MM,de Gast GC,Nieweg HO

更新日期：1975-01-01 00:00:00

abstract：:The concentration of plasma vitamin B12 bound to transcobalamin II was measured by two methods: QUSO and Heparin Sepharose (HS). The new HS procedure provided a specific, direct measurement of vitamin B12 bound to both R binder and transcobalamin II in plasma. ...

journal_title：Acta haematologica

authors： Benhayoun S,Adjalla C,Nicolas JP,Guéant JL,Lambert D

更新日期：1993-01-01 00:00:00

abstract：:We describe a case of hemolytic anemia with subacute bacterial endocarditis due to Streptococcus sanguis. The major hematological features of the patient were a normocytic anemia with reticulocytosis, an elevation of serum lactate dehydrogenase, and a marked reduction of serum haptoglobin. All these signs of hemolytic...

journal_title：Acta haematologica

authors： Inada T,Shirono K,Tsuda H

更新日期：1995-01-01 00:00:00

abstract：:A 69-year-old woman presented with chronic lymphocytic leukemia (CLL) diagnosed after bone marrow recovery following intensive chemotherapy for acute lymphoblastic leukemia. The retrospective diagnosis of initial blastic transformation of CLL was made. The patient eventually died, 5 months after initial blastic phase,...

journal_title：Acta haematologica

authors： Archimbaud E,Charrin C,Gentilhomme O,Rimokh R,Guyotat D,Fiere D,Germain D

更新日期：1988-01-01 00:00:00

abstract：:In a comparison of 47 patients with Philadelphia-chromosome (Ph)-positive chronic myeloid leukemia (CML) in the Nagasaki University School of Medicine and 64 patients with the same disease in the Roswell Park Memorial Institute, the correlation between the modal number of chromosomes and the therapeutic response and/o...

journal_title：Acta haematologica

authors： Sadamori N,Yao E,Mine M,Tokunaga S,Matsunaga M,Nakamura H,Sasagawa I,Itoyama T,Hayashibara T,Sandberg AA

更新日期：1992-01-01 00:00:00

abstract：:A 12-year-old male of Chinese ancestry had life-long hemolytic anemia attributed to alpha-thalassemia. Restriction endonuclease mapping of his DNA revealed that in reality, he had three alpha-globin loci, but he was homozygous for pyruvate kinase deficiency. The new pyruvate kinase variant carried by this patient was ...

journal_title：Acta haematologica

authors： Beutler E,Forman L

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Not all patients with diffuse large B-cell lymphoma (DLBCL) are candidates for aggressive regimens. (90)Y ibritumomab tiuxetan ((90)Y-IT), an anti-CD20 radionuclide-conjugated antibody, has demonstrated clinical efficacy in DLBCL with a favorable toxicity profile. METHODS:This phase II trial investigated th...

journal_title：Acta haematologica

authors： Arnason JE,Luptakova K,Rosenblatt J,Tzachanis D,Avigan D,Zwicker JI,Levine J,Kim M,Parker JA,Grant B,Joyce RM

更新日期：2015-01-01 00:00:00

abstract：:A patient with common acute lymphoblastic leukaemia (ALL), hypereosinophilic syndrome and t(5;14) (q31.1;q32.3) translocation is described. Even with intensive treatment only short periods of complete remission were achieved. Recurrence of the leukaemia was always accompanied by the appearance of eosinophilic granuloc...

journal_title：Acta haematologica

authors： Baumgarten E,Wegner RD,Fengler R,Ludwig WD,Schulte-Overberg U,Domeyer C,Schüürmann J,Henze G

更新日期：1989-01-01 00:00:00