Oral versus intravenous fludarabine as part of a reduced-intensity conditioning for allogeneic stem cell transplantation.

abstract：:A new variant of red cell glucose-6-phosphate dehydrogenase (G6PD) has been found in a Caucasian man with congenital non-spherocytic haemolytic anaemia. This variant has reduced activity, increased thermolability, increased Michaelis constants for glucose-6-phosphate and NADP, slightly increased electrophoretic mobili...

journal_title：Acta haematologica

authors： Mandelli F,Amadori S,De Laurenzi A,Kahn A,Isacchi G,Papa G

更新日期：1977-01-01 00:00:00

abstract：:Coagulation factor VIII inhibitor arising in a patient with autoimmune disease was immunologically analyzed. A 63-year-old man who had been diagnosed as suffering from polyarteritis nodosa was treated with prednisolone for 10 years. Severe bleeding tendency developed and coagulation studies demonstrated a high titer o...

journal_title：Acta haematologica

authors： Okamura T,Yamauchi Y,Fukuda T,Suehiro K,Murakawa M,Shibuya T,Nagasawa K,Harada M,Niho Y

更新日期：1991-01-01 00:00:00

abstract：:The in vitro immune functions of peripheral blood lymphocytes have been studied in 12 children with beta-thalassaemia major and hypersplenism. The study was performed prior to splenectomy and on the 2nd, 6th, 15th and 30th day after splenectomy. It was found that before splenectomy, patients had low numbers of blood l...

journal_title：Acta haematologica

authors： Mandalenaki-Lambrou K,Vrachnou E,Calogeropoulou C,Ladis V,Kattamis C

更新日期：1987-01-01 00:00:00

abstract：:Cancer patients not undergoing treatment and without a history of venous thrombosis do not, as a general rule, require prophylaxis. However, venous thromboembolism is of sufficient magnitude in patients undergoing treatment for cancer for thromboprophylaxis to be routinely employed. The mainstay of primary prevention ...

journal_title：Acta haematologica

authors： Thodiyil PA,Walsh DC,Kakkar AK

更新日期：2001-01-01 00:00:00

abstract：:The effects of lithium on the microtubular and microfilament systems of neutrophil granulocytes is described. The phagocytic capacity of human neutrophils was reduced or inhibited by using vinblastine or cytochalasin B. Lithium at concentrations ranging from 0.5 to 2.0 mEq/l proved to be capable of antagonising the ac...

journal_title：Acta haematologica

authors： Carulli G,Marini A,Azzarà A,Petrini M,Ruocco L,Ambrogi F

更新日期：1985-01-01 00:00:00

abstract：:In 83 children with acute lymphoblastic leukaemia (ALL) the immunological phenotype of the lymphoblasts was determined using E rosetting, monoclonal anti-T cell sera, surface immunoglobulin staining and common ALL antiserum. The data were compared with acid alpha-naphthyl acetate esterase (ANAE) and acid phosphatase (...

journal_title：Acta haematologica

authors： Veerman AJ,Huismans DR,van Zantwijk CH

更新日期：1983-01-01 00:00:00

abstract：:To evaluate the effect of granulocyte/colony-stimulating factor (G-CSF) on the onset of the adult respiratory distress syndrome (ARDS), we investigated whether the incidence of ARDS due to pulmonary infection differed between the G-CSF group which received chemotherapy with G-CSF and historical controls without G-CSF....

journal_title：Acta haematologica

authors： Takahashi Y,Kobayashi Y,Chikayama S,Ikeda M,Kondo M

更新日期：1999-01-01 00:00:00

abstract：:Leukemic cells of a patient with acute T-lymphoblastic leukemia (T-ALL) exhibiting the uncommon clinical feature of hypogammaglobulinemia were examined in terms of surface markers and immunologic functions. Employing various monoclonal reagents reacting with surface antigens present on T cells and additional conventio...

journal_title：Acta haematologica

authors： Herrmann F,Sieber G,Komischke B,Oestreich R,Rühl H

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:We investigated the prevalence of opportunistic infections in HIV-infected women according to transferrin (TF) phenotype. METHODS:We conducted a cross-sectional study among 200 HIV-positive women in the Butare University Teaching Hospital in Rwanda. TF phenotypes were determined using starch gel electrophore...

journal_title：Acta haematologica

authors： Masaisa F,Gahutu JB,Mukiibi J,Delanghe J,Philippé J

更新日期：2012-01-01 00:00:00

abstract：:Systematic reviews and meta-analyses have made a major contribution to the evidence-based management of infections in cancer patients. We review the contribution of systematic reviews with regard to antibiotic, antifungal, antiviral and Pneumocystis pneumonia prophylaxis; antibiotic and antifungal treatment of febrile...

journal_title：Acta haematologica

authors： Paul M,Gafter-Gvili A,Goldberg E,Yahav D

更新日期：2011-01-01 00:00:00

abstract：:The concentration of plasma vitamin B12 bound to transcobalamin II was measured by two methods: QUSO and Heparin Sepharose (HS). The new HS procedure provided a specific, direct measurement of vitamin B12 bound to both R binder and transcobalamin II in plasma. ...

journal_title：Acta haematologica

authors： Benhayoun S,Adjalla C,Nicolas JP,Guéant JL,Lambert D

更新日期：1993-01-01 00:00:00

abstract：:Successive chromatographic procedures made it possible to isolate thrombocytopoietin from the serum of thrombocytopenic rats. The following steps were taken: DEAE-cellulose phosphate chromatography, Sephadex chromatography, exclusion chromatography on DEAE-Sephadex A-50 gel. The apparent molecular weight of thrombocyt...

journal_title：Acta haematologica

authors： Dassin E,Bourebia J,Najean Y,Rosset AM

更新日期：1983-01-01 00:00:00

abstract：:Human beta-globin was produced in Escherichia coli as a cleavable fusion protein using the expression vector pLcII [Nagai and Thøgersen, Nature 301, p. 810, 1984]. The fusion protein CIIFX beta-globin was purified under denaturing conditions to homogeneity and the authentic beta-globin was liberated by blood coagulati...

journal_title：Acta haematologica

authors： Luisi BF,Nagai K,Perutz MF

更新日期：1987-01-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an interferon (IFN)-induced molecule with apoptotic activity. We examined gene mutations in the death domains of TRAIL receptor 1 (TRAIL-R1) and TRAIL receptor 2 (TRAIL-R2), and in the TRAIL gene promoter in 46 chronic myelogenous leukemia (CML) patien...

journal_title：Acta haematologica

authors： Liu LG,Tanaka H,Ito K,Ito T,Sultana TA,Kyo T,Kimura A

更新日期：2005-01-01 00:00:00

abstract：:Recently, concerns have been raised regarding the potential impairment of neonatal platelet function and the potential risk of bleeding in neonates born to mothers treated with selective serotonin reuptake inhibitors (SSRI). Our aim was to test whether the platelet function of neonates born to SSRI-treated mothers was...

journal_title：Acta haematologica

authors： Maayan-Metzger A,Kuint J,Lubetsky A,Shenkman B,Mazkereth R,Kenet G

更新日期：2006-01-01 00:00:00

abstract：:An increased bone marrow (BM) apoptosis is one of the mechanisms responsible for the ineffective hematopoiesis of myelodysplastic syndromes (MDS). It is controversial whether the excessive apoptosis in myelodysplasia predominantly involves the subset of progenitor cells or of maturing cells. We investigated the degree...

journal_title：Acta haematologica

authors： Pecci A,Travaglino E,Klersy C,Invernizzi R

更新日期：2003-01-01 00:00:00

abstract：:A 28-year-old woman with Bence-Jones multiple myeloma (MM) presented with several osteolytic lesions and a massive bone marrow infiltration with mature plasmocytes. After 6 cycles of chemotherapy with melphalan and prednisone, the patient, in apparent clinical remission, underwent allogeneic bone marrow transplantatio...

journal_title：Acta haematologica

authors： Gallamini A,Buffa F,Bacigalupo A,Van Lint MT,Peralvo J,Pittaluga PA,Occhini D,Marmont AM

更新日期：1987-01-01 00:00:00

abstract：:Glucocorticosteroid hormones have been reported either to stimulate or to inhibit human erythropoiesis. We have studied the in vitro effect of hydrocortisone, 10(-6) mol/l, on human BFU-E when stimulated by preconstituted burst-promoting activity (BPA) in a medium conditioned by T lymphocytes. Hydrocortisone was found...

journal_title：Acta haematologica

authors： Morra L,Ponassi A,Moccia F,Mela GS,Ponassi I,Bessone G

更新日期：1989-01-01 00:00:00

abstract：:In the chronic wound, the normal cascade of inflammation, granulation and reconstruction phases of healing is interrupted. Cytokines are now known to orchestrate different biochemical mediators resulting in the restoration of the healing phases. Growth factors may play a significant role in stimulating wound repair by...

journal_title：Acta haematologica

authors： Nath C,Gulati SC

更新日期：1998-01-01 00:00:00

abstract：:In a 42-year-old Caucasian female, acute myelocytic leukemia (M2) presented as occlusion of the distal aorta and right iliac artery. She died after 10 days of respiratory failure. At postmortem examination the aortic wall contained multiple thrombi composed of fibrin and leukemic cells. There was no evidence of diffus...

journal_title：Acta haematologica

authors： Kootte AM,Thompson J,Bruijn JA

更新日期：1986-01-01 00:00:00

abstract：:Platelet functions were evaluated in 20 healthy pregnant women in the last months of pregnancy, during labor, and 5-12 weeks after labor. The results showed an increased platelet count, bleeding time and nitroblue tetrazolium (NBT) test, as well as an increased plasma calcium level postlabor. ADP- and epinephrine-indu...

journal_title：Acta haematologica

authors： Sagi A,Creter D,Goldman J,Djaldetti M

更新日期：1981-01-01 00:00:00

abstract：:The increased longevity of patients with thalassemia and sickle cell disease (SCD) introduces new clinical challenges due to the accumulation of disease-related morbidity, psychosocial issues and health care adjustments. Patients with thalassemia major now live into adulthood without suffering heart failure but must c...

journal_title：Acta haematologica

authors： Yacobovich J,Tamary H

更新日期：2014-01-01 00:00:00

abstract：:15 patients with aplastic anemia were prospectively followed after having measurements of myeloid progenitor cells in bone marrow and blood. Treatment included androgens, low or high dose steroids and standardized supportive care. The median length of survival was 5.8 months. When patients were grouped according to th...

journal_title：Acta haematologica

authors： Hinterberger W,Geissler K,Fischer M,Lechner K,Kabrna E

更新日期：1985-01-01 00:00:00

abstract：:The course and management of avascular necrosis of the femoral head (AVNFH) in six hips of 5 sickle cell syndrome patients (3 with Hb SS, 1 with Hb SC and 1 with Hb S/beta+-thalassaemia) are described. Two patients (aged 13 and 17 years) presented with Perthes- and osteochondritis dessicans-type lesions. These hips pr...

journal_title：Acta haematologica

authors： Rand C,Pearson TC,Heatley FW

更新日期：1987-01-01 00:00:00

abstract：:Serum soluble interleukin-6 receptor (sIL-6R) concentrations were measured in 50 patients with plasma cell dyscrasias using a commercially available immunoenzymatic assay kit. There were 40 patients with multiple myeloma (MM), 5 patients with monoclonal gammopathy of undetermined significance (MGUS), 3 patients with s...

journal_title：Acta haematologica

authors： Papadaki H,Kyriakou D,Foudoulakis A,Markidou F,Alexandrakis M,Eliopoulos GD

更新日期：1997-01-01 00:00:00

abstract：:A family with hereditary ovalocytosis (HO) is described. The probands, 2 brothers, had splenic rupture after modest trauma as preenting symptoms. 7 members of the family had HO. The sister of the pobands had a moderately enlarged spleen. The other members proved normal on routine clinical examination. ...

journal_title：Acta haematologica

authors： Kjellman B,Larsson C,Tibblin E

更新日期：1980-01-01 00:00:00

abstract：:We have used the gel retardation assay to investigate the binding of nuclear proteins to the duplicated CACCC boxes in the beta-globin gene promoter region. The effect of beta-thalassemia mutations affecting both of these consensus sequences (the -88 C-->T and -101 C-->T mutations) were studied by using appropriate mu...

journal_title：Acta haematologica

authors： Baysal E,Ribeiro ML,Huisman TH

更新日期：1994-01-01 00:00:00

abstract：:Cardiac scintigraphy has been performed in 60 beta-thalassaemia major patients aged 8-35 years who received regular blood transfusions and subcutaneous desferrioxamine (DFX) chelation. Fifty-seven showed no clinical, radiological or electrocardiographic evidence of heart disease and 3 had clinically apparent cardiac f...

journal_title：Acta haematologica

authors： Aldouri MA,Wonke B,Hoffbrand AV,Flynn DM,Ward SE,Agnew JE,Hilson AJ

更新日期：1990-01-01 00:00:00

abstract：:Thrombopoietin levels in thrombocytopenic mice assayed by 75Se-se-lenomethionine incorporation into blood platelets reached a maximum 12 h after the induction of an acute, immune thrombocytopenia; that was more than twice the value in control mice. The implications of this finding are discussed with reference to the k...

journal_title：Acta haematologica

authors： Nakeff A,Roozendaal KJ

更新日期：1975-01-01 00:00:00

abstract：:The activity of gamma-glutamyl transpeptidase was investigated in normal and leukemia leukocytes. Enzyme activity was positively correlated with the proportion of mature neutrophils and monocytes. In isolated leukocytes from patients with acute myeloid leukemia low values were obtained compared to controls. ...

journal_title：Acta haematologica

authors： Hultberg B,Sjögren U

更新日期：1980-01-01 00:00:00