Abstract:
:A patient with common acute lymphoblastic leukaemia (ALL), hypereosinophilic syndrome and t(5;14) (q31.1;q32.3) translocation is described. Even with intensive treatment only short periods of complete remission were achieved. Recurrence of the leukaemia was always accompanied by the appearance of eosinophilic granulocytes in the blood and in the bone marrow. Although there is no experimental proof we assume that the hypereosinophilic syndrome is causally related to the chromosome aberration. Translocation of the GM-CSF gene from chromosome No. 5 to chromosome No. 14, might have led to the deregulation of the gene by enhancer sequences of the immunoglobulin heavy-chain region on chromosome No. 14, with the consequence of an overproduction of neutrophilic and particularly eosinophilic granulocytes. Furthermore, stimulation of the leukaemic cell clone may have occurred by this translocation. The similarity of the clinical course with cases described in the literature suggests that this condition is a unique entity of ALL.
journal_name
Acta Haematoljournal_title
Acta haematologicaauthors
Baumgarten E,Wegner RD,Fengler R,Ludwig WD,Schulte-Overberg U,Domeyer C,Schüürmann J,Henze Gdoi
10.1159/000205289subject
Has Abstractpub_date
1989-01-01 00:00:00pages
85-90issue
2eissn
0001-5792issn
1421-9662journal_volume
82pub_type
杂志文章abstract::Amylase-producing tumors are mainly adenocarcinomas and, in rare instances, multiple myelomas. We describe here a first case of amylase-producing Bence Jones type myeloma with pancreatitis-like symptoms and the second in a Caucasian patient. The finding of salivary-type hyperamylasemia in a 72-year-old female with a p...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204384
更新日期:1993-01-01 00:00:00
abstract::The activity of gamma-glutamyl transpeptidase was investigated in normal and leukemia leukocytes. Enzyme activity was positively correlated with the proportion of mature neutrophils and monocytes. In isolated leukocytes from patients with acute myeloid leukemia low values were obtained compared to controls. ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207384
更新日期:1980-01-01 00:00:00
abstract::Pyrimidine 5'-nucleotidase (P5'N) partial deficiency has been described in several hematological disorders and also in the beta-thalassemic trait. To check if the P5'N deficiency in thalassemia was acquired we used thalassemic red cells (from either homo- or heterozygous subjects), whose P5'N activity was lower than i...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205286
更新日期:1989-01-01 00:00:00
abstract::We describe a case of hemolytic anemia with subacute bacterial endocarditis due to Streptococcus sanguis. The major hematological features of the patient were a normocytic anemia with reticulocytosis, an elevation of serum lactate dehydrogenase, and a marked reduction of serum haptoglobin. All these signs of hemolytic...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000203981
更新日期:1995-01-01 00:00:00
abstract::We evaluated the iron status of 50 Sicilian patients with G6PD deficiency under steady-state conditions and compared our results with those for 50 control patients. We studied haemolysis and iron indices to evaluate the iron balance. These patients could be considered to be at risk of iron overload as a result of incr...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204368
更新日期:1993-01-01 00:00:00
abstract::Recently, concerns have been raised regarding the potential impairment of neonatal platelet function and the potential risk of bleeding in neonates born to mothers treated with selective serotonin reuptake inhibitors (SSRI). Our aim was to test whether the platelet function of neonates born to SSRI-treated mothers was...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000090929
更新日期:2006-01-01 00:00:00
abstract::Successive chromatographic procedures made it possible to isolate thrombocytopoietin from the serum of thrombocytopenic rats. The following steps were taken: DEAE-cellulose phosphate chromatography, Sephadex chromatography, exclusion chromatography on DEAE-Sephadex A-50 gel. The apparent molecular weight of thrombocyt...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206900
更新日期:1983-01-01 00:00:00
abstract::Malaria parasites growing inside human erythrocytes differ from mammalian cells in their mode of acquisition of bioavailable iron and in their susceptibility to the antiproliferative action of iron chelators. We have assessed here three major properties associated with these phenomena: (a) the stage-dependent nature o...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000203952
更新日期:1996-01-01 00:00:00
abstract::Although multiple myeloma (MM) remains an incurable disease, its treatment has improved over the past decade. This improvement has been at least in part due to the introduction of novel antimyeloma agents with new mechanisms of action, including those that target both myeloma cells and the tumor microenvironment, with...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000094682
更新日期:2006-01-01 00:00:00
abstract::von Willebrand disease (VWD) type 2M is a distinct entity and clearly differs from type 1. The genotype-phenotype correlation for cases with ristocetin cofactor activity (RCo)/antigen (Ag) ratios <0.60 is clear, whereas the von Willebrand factor (VWF):collagen binding (CB)/VWF:Ag ratio is normal in VWD 2M. Typical lab...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000214854
更新日期:2009-01-01 00:00:00
abstract::An improved plasma clot culture method for CFU megakaryocytes (MK) has been developed with a higher plating efficiency and easier identification and enumeration of MK colonies by an indirect immunoperoxidase staining using a monoclonal antibody specific to the platelet glycoprotein IIb/IIIa complex. This technique has...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205837
更新日期:1987-01-01 00:00:00
abstract::A 74-year-old woman was treated by lithium carbonate 3 x 300 mg per day for drug-induced aplastic anemia. After 8 days, she suddenly developed severe impairment of consciousness with myoclonias and hypertonia which persisted during 10 days despite lithium withdrawal and sodium chloride infusion. Slight disorders of wa...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207314
更新日期:1980-01-01 00:00:00
abstract::Extensive bone marrow necrosis and symptomatic hypercalcemia have been described independently as rare complications of chronic myeloid leukemia. Here we report a 66-year-old man who developed B cell blastic transformation 10 years after diagnosis of CML in the chronic phase. Extensive bone marrow necrosis and symptom...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000106100
更新日期:2007-01-01 00:00:00
abstract::34 patients with myocardial infarction were studied with daily measurements of beta-thromboglobulin (BTG) and 125I fibrinogen scanning in order to detect deep-venous thrombosis (DVT). Serial levels of BTG were unhelpful in the early detection of this condition, which occurred in 7 of the patients studied. 5 of the pat...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207238
更新日期:1980-01-01 00:00:00
abstract::The most common single genetic disorder and a major public health issue in Greece and other Mediterranean countries is beta-thalassemia. Current therapeutic approaches for homozygous beta-thalassemia entail blood transfusions and iron chelation therapy with deferoxamine or deferiprone for preventing tissue hemosideros...
journal_title:Acta haematologica
pub_type: 临床试验,杂志文章
doi:10.1159/000077551
更新日期:2004-01-01 00:00:00
abstract::Acute myelogenous leukemia (AML) of the inbred Wistar/Furth (W/Fu) rat is pathophysiologically similar to human AML. Subcutaneous transplantation of 1.0 X 10(6) cells of a clonal tissue culture line of W/Fu AML into 6- to 8-week-old rats produced local myeloblastomas in 8--10 days which progressed to infiltration of r...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207886
更新日期:1977-03-01 00:00:00
abstract::A 66-year-old Japanese woman was referred to us because of severe anemia and fever and presented at our hospital. She was eventually diagnosed as having acute myeloblastic leukemia (AML; M0) with non-Hodgkin lymphoma (NHL). We investigated the therapeutic efficacy of L-asparaginase (L-Asp), vincristine and prednisolon...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000243725
更新日期:2009-01-01 00:00:00
abstract::It was confirmed that activation of the kallikrein-kinin enzyme system in cryoglobulinemia might be initiated by activation of factor XII to factor XIIa by cryoglobulin. It was also demonstrated that cryoglobulin or fibrin clots lost their ability to redissolve on warming to 37 degrees C, and consequently the lysis ti...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206563
更新日期:1984-01-01 00:00:00
abstract::Treatment of acute lymphoblastic leukemia is unsatisfactory in adults due to disease and patient-related factors and probably because adult chemotherapy regimens are weaker than pediatric protocols. Worries about inadequacy of adult regimens urged many hematologists, including us, to reconsider their routine treatment...
journal_title:Acta haematologica
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000351172
更新日期:2013-01-01 00:00:00
abstract::Peripheral blood stem cells (PBSC) are widely used in the setting of dose-intensive chemotherapies in patients with multiple myeloma (MM). Although the granulocyte colony-stimulating factor (G-CSF), following chemotherapy or not, is considered the standard growth factor for mobilizing PBSC, the optimal chemotherapeuti...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000070967
更新日期:2003-01-01 00:00:00
abstract::Eleven patients with acute myeloid leukaemia (AML) in first complete remission (CR) were treated with alfa-2a-interferon (for short 'interferon') maintenance therapy, at a dose of 3 MU twice to thrice weekly subcutaneously. Adjustments were made to maintain neutrophil counts > 1 x 10(9)/l and platelet counts > 100 x 1...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204473
更新日期:1993-01-01 00:00:00
abstract::In the diagnosis of multiple myeloma (MM), the radiological skeletal survey (RSS) was proven to be most useful for the detection of bone lesions. Since 1961, a new technique radioisotopic bone scan (RIBS), for the detection of such lesions, using 85Sr and 99mTc, has been shown to be highly sensitive for the detection ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206898
更新日期:1983-01-01 00:00:00
abstract::Inferferon alfa-2b (IFN) plays a major role in the current management of previously untreated patients with chronic myelogenous leukemia (CML) as well as patients with CML who have relapsed after bone marrow transplantation. Hydroxyurea (HU) is the best conventional drug for treatment of CML in the chronic phase. Ten ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000203859
更新日期:1996-01-01 00:00:00
abstract::We review the problem of lymphoma classification in the light of the Revised European-American Lymphoma (REAL) scheme, recently proposed by the International Lymphoma Study Group (ILSG). The REAL classification is a list of clinicopathologic entities, all well known from the literature, upon which the ILSG members agr...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000203875
更新日期:1996-01-01 00:00:00
abstract::We evaluated an enzyme-linked immunosorbent assay (ELISA) for embryonic zeta-globin chains as a routine screening test for (--(SEA)) alpha-thalassemia deletion (SEA deletion). A total of 174 consecutive patient samples with a request for Hb analysis were recruited. The ELISA method was evaluated against a polymerase c...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000063060
更新日期:2002-01-01 00:00:00
abstract::The plasma cortisol levels of 108 children aged 1-16 years with various Hb genotypes (AA, AS and SS) were measured. The mean plasma cortisol levels of both the AS and SS groups (during steady state) fell within the normal range but the mean of the SS group is significantly lower than the AA group. In fact, 9 of the si...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205689
更新日期:1988-01-01 00:00:00
abstract::We have demonstrated that hemopoietic organ fibroblastoid cells can produce colony-stimulating activity (CSA) in vitro. Skin fibroblasts also produced CSA. The colonies which formed were restricted to the granulocyte/macrophage differentiation pathways. A linear relationship was obtained for granulocyte/macrophage col...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206924
更新日期:1983-01-01 00:00:00
abstract::Neurologic complications of allogeneic hematopoietic cell transplantation (allo-HCT) include infections, cerebrovascular events, therapy-induced neurotoxicity, recurrent malignancies, and neurologic manifestations of graft-versus-host disease (GVHD). Anti-glutamic acid decarboxylase (GAD) antibody-associated cerebella...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000494423
更新日期:2019-01-01 00:00:00
abstract::Mesenteric panniculitis is a rare idiopathic inflammatory disorder that can lead to sclerosis. We describe a patient with mesenteric panniculitis presenting with abdominal symptoms and autoimmune haemolytic anaemia. The symptoms remitted after splenectomy and gradual steroid taper. This may suggest an autoimmune compo...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000046627
更新日期:2002-01-01 00:00:00
abstract::Differentiation of rapidly binding coagulation factor inhibitors from antiphospholipid antibodies is a challenge for the hemostaseologic laboratory, especially with respect to the different therapeutic consequences. Several immunological and functional assays for the diagnosis of these disorders have been proposed. He...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000040821
更新日期:1998-01-01 00:00:00