Abstract:
:Differentiation of rapidly binding coagulation factor inhibitors from antiphospholipid antibodies is a challenge for the hemostaseologic laboratory, especially with respect to the different therapeutic consequences. Several immunological and functional assays for the diagnosis of these disorders have been proposed. Here we report the clinical and laboratory findings of a 65-year-old man who developed severe bleeding after a tooth extraction. The process leading to the diagnosis of a spontaneous atypical factor VIII inhibitor and the value of different laboratory tests are discussed.
journal_name
Acta Haematoljournal_title
Acta haematologicaauthors
Steinbrueckner B,Steigerwald U,Keller F,Ordung R,Neuenroth L,Reuther J,Klinker H,Schwender Sdoi
10.1159/000040821subject
Has Abstractpub_date
1998-01-01 00:00:00pages
102-5issue
2eissn
0001-5792issn
1421-9662pii
40821journal_volume
99pub_type
杂志文章abstract::350 patients with idiopathic thrombocytopenic purpura (ITP) aged 2/12-15 years (mean 6.3 +/- 2.7) were followed up during the period January 1st, 1975 to March 31, 1992. They constituted 40% of cases with hemorrhagic diathesis attending the Hematology/Oncology Clinic, Children's Hospital, Ain Shams University (relativ...
journal_title:Acta haematologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000204392
更新日期:1993-01-01 00:00:00
abstract::The detection of cellular antigens in bone marrow sections depends on the method of embedding, the nature of antigen and antibody, antigen retrieval techniques and the sensitivity of the immunohistochemical method. This study evaluated a fluorescyl-tyramide-enhanced immunostaining method on methyl-methacrylate-embedde...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000097458
更新日期:2007-01-01 00:00:00
abstract::In pregnant mice. 55Fe-labeled iron-dextran (Imferon) is transferred across the placenta. It was detected in the bone marrow, liver, spleen and peripheral blood of the pregnant animal, as well as in the embryonic liver erythroid precursors and peripheral blood. Uptake by liver and peripheral blood cells of pregnant an...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000208195
更新日期:1975-01-01 00:00:00
abstract::The activity of ten red blood cell enzymes, including hexokinase, has been measured in 6 Fanconi's anemia patients. In disagreement with previous reports, in no instance were reduced or increased hexokinase levels found. Furthermore, the hexokinase isozymic pattern, thermostability, pH dependence of activity and kinet...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206612
更新日期:1984-01-01 00:00:00
abstract::Basic fibroblast growth factor (b-FGF) mediates a variety of biological responses such as angiogenesis and hematopoiesis. We examined the effect of b-FGF on human neutrophil functions in vitro. The surface expression of effector cell molecules on neutrophils was determined by flow cytometry and monoclonal antibodies. ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000041024
更新日期:2000-01-01 00:00:00
abstract::A case of Philadelphia-positive (Ph) acute lymphoblastic leukaemia (ALL) in a 40-year-old male is presented. At diagnosis, 80% of bone marrow cells were Ph. Remission with normal blood counts was achieved but the marrow became hypercellular, indicating conversion to chronic granulocytic leukaemia (GCL). The Ph clone p...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204497
更新日期:1993-01-01 00:00:00
abstract::A 77-year-old woman presented to the outpatient hematology clinic in August 2001 with leukocytosis, recurrent bacterial infections, sweating and weight loss. Bone marrow biopsy showed 80% infiltration with lymphoid cells having a prolymphocytic morphology. Flow-cytometric immunophenotype analysis showed that over 80% ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000076527
更新日期:2004-01-01 00:00:00
abstract::Sera from 154 hemophiliacs, including 132 with hemophilia A and 22 with hemophilia B, were examined for antibodies against human T cell lymphotropic virus type III (HTLV-III) and type I by strip radioimmunoassay based on the Western blotting technique. Sixty-two patients lived in Kyushu, a known endemic area of HTLV-I...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205944
更新日期:1987-01-01 00:00:00
abstract::Using labelled erythrocytes and human serum albumin, the volume of circulating erythrocytes and plasma was determined in the spleen and individual parts of the skeleton of mice under physiological conditions and 48 h after X-irradiation with a dose of 2,87 Gy. The results are significant for the interpretation of the ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207231
更新日期:1980-01-01 00:00:00
abstract::Richter syndrome (RS) describes the development of high-grade non-Hodgkin's lymphoma (NHL) from low-grade NHL. RS isolated to the brain is very rare and has a poor prognosis. We describe the cases of high-grade large B-cell diffuse NHL in a 56-year-old male with chronic lymphocytic leukemia and in a 71-year-old female...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000334068
更新日期:2012-01-01 00:00:00
abstract::Gene therapy targeting hematopoietic cells has arrived at a new stage of potency. While the potential for curing inherited disorders of the immune system has been demonstrated in clinical trials, we were also confronted with the first serious adverse events related to random insertion of foreign DNA into cellular chro...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000072459
更新日期:2003-01-01 00:00:00
abstract::A patient with regional enteritis had received iron dextran for treatment of iron deficiency. Subsequently he developed a large (3.1 g/100 ml) IgG-K serum spike which had precipitin activity against dextran sulfate but not a variety of other antigens. There has been no evidence of multiple myeloma and the spike gradua...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207755
更新日期:1978-01-01 00:00:00
abstract::A hemophilia B patient, seropositive for HIV antibodies since 1984, came to us in March 1989 with a severe necrotizing lesion of the nose. It was an erythematous lesion and looked like rhinophyma. Microbiological examination of the skin biopsy showed the presence of Cryptococcus neoformans. At the time of the study, t...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205038
更新日期:1990-01-01 00:00:00
abstract::Immunologic abnormalities have been described in patients with Hodgkin lymphoma, including autoimmune hemolytic anemia and immune thrombocytopenic purpura. The concurrent diagnoses of Hodgkin lymphoma and acquired aplastic anemia, however, is extremely rare. We report a 56-year-old Japanese female patient with severe ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000100038
更新日期:2007-01-01 00:00:00
abstract::In a 42-year-old Caucasian female, acute myelocytic leukemia (M2) presented as occlusion of the distal aorta and right iliac artery. She died after 10 days of respiratory failure. At postmortem examination the aortic wall contained multiple thrombi composed of fibrin and leukemic cells. There was no evidence of diffus...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206100
更新日期:1986-01-01 00:00:00
abstract::To clarify the role of thrombopoietin (c-Mpl ligand, TPO) in 'hypersplenic' thrombocytopenia, we used an enzyme-linked immunosorbent assay to examine changes in serum TPO levels accompanied with splenectomy in 6 patients with liver cirrhosis, 4 patients with gastric cancer, and 2 patients with lymphoid malignancies. W...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000040888
更新日期:1998-12-01 00:00:00
abstract::Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a rare lymphoproliferative disorder characterized by diffuse lymphadenopathy, fever, hepatosplenomegaly, hemolytic anemia, and polyclonal hypergammaglobulinemia. Morphologically, the involved lymph nodes demonstrate complete effacement of the normal arch...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000040811
更新日期:1998-01-01 00:00:00
abstract::12 thalassaemic patients from Northern Sardinia showing the beta + phenotype were examined by isoelectric focusing and high-performance liquid chromatography techniques for the determination of the variant A gamma T globin chain of the foetal haemoglobin. Two patients (16.7%) were homozygotes for the A gamma T gene va...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206057
更新日期:1986-01-01 00:00:00
abstract::Drug-induced immune hemolytic anemia is a rare but underdiagnosed and potentially fatal condition. We report a case of severe hemolytic anemia induced by cefoxitin in a 45-year-old woman admitted with menometrorrhagia. Hemoglobin levels reached a nadir of 4.7 g/dl approximately 72 h after cefoxitin initiation, and hem...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000320169
更新日期:2010-01-01 00:00:00
abstract::von Willebrand disease (VWD) type 2M is a distinct entity and clearly differs from type 1. The genotype-phenotype correlation for cases with ristocetin cofactor activity (RCo)/antigen (Ag) ratios <0.60 is clear, whereas the von Willebrand factor (VWF):collagen binding (CB)/VWF:Ag ratio is normal in VWD 2M. Typical lab...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000214854
更新日期:2009-01-01 00:00:00
abstract::Slow intravenous infusion of Na laurate (NaL) into guinea pigs caused a rapid appearance of platelet aggregates in the arterial blood and a precipitous fall in platelet counts. During the infusion of Na arachidonate (NaA) thrombocytopenia developed slowly, and few and smaller platelet aggregates appeared in the arteri...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207864
更新日期:1977-01-01 00:00:00
abstract::A 59-year-old man with beta-thalassaemia major is unusually well. He has no beta-chains in his haemoglobin but is heterozygous for the genes responsible for alphaA and for alphaG Philadelphia. In addition he is also heterozygous for the genes responsible for gammaF and a new gamma-chain, gamma75(E19) Ile-Thr, named ga...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000208204
更新日期:1975-01-01 00:00:00
abstract::A 64-year-old man with multiple sclerosis developed a circulating anticoagulant. Three immunoglobulin fractions (I = IgG; II =IgG+IgA; III = IgM) were separated from patient serum by 33-percent ammonium sulfate precipitation and DEAE-52 cellulose column chromatography. Fractions I (IgG) and II (IgG+IgA) had factor VII...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207993
更新日期:1976-01-01 00:00:00
abstract::We investigated double (specific and nonspecific) esterase (DE) staining in marrow cells of 237 patients with the myelodysplastic syndromes (MDS). Additional abnormalities of neutrophilic granules were examined cytochemically and immunocytochemically for myeloperoxidase activity and antigen elastase, lactoferrin and C...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000040855
更新日期:1998-01-01 00:00:00
abstract::The BCR-ABL fusion gene represents the hallmark of chronic myelogenous leukemia (CML) and is derived from a translocation between chromosome 9 and 22. The majority of CML patients have a breakpoint in the major BCR region of the BCR gene giving rise to e13a2 or e14a2 BCR-ABL transcripts. Occasionally, other BCR breakp...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000230037
更新日期:2009-01-01 00:00:00
abstract::One of the major determinants of erythrocyte survival is membrane deformability, and an important intrinsic parameter of membrane deformability is the shear elastic modulus (mu) with higher mu values corresponding to increased membrane rigidity. Using a micropipette technique, we determined the shear elastic modulus o...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204753
更新日期:1992-01-01 00:00:00
abstract::Serum soluble interleukin-6 receptor (sIL-6R) concentrations were measured in 50 patients with plasma cell dyscrasias using a commercially available immunoenzymatic assay kit. There were 40 patients with multiple myeloma (MM), 5 patients with monoclonal gammopathy of undetermined significance (MGUS), 3 patients with s...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000203682
更新日期:1997-01-01 00:00:00
abstract::Agranulocytosis is a rare side effect of phenytoin treatment. We describe the case of an elderly man who developed agranulocytosis 2 weeks following initiation of phenytoin treatment, on no cytotoxic drugs or any other medications except decadron. The white blood cell count was 300/mm3 with absent granulocytes. The li...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204838
更新日期:1991-01-01 00:00:00
abstract::95 of 1,019 (9.3%) sera with monoclonal immunoglobulins (MIg) were found to have cold-reacting lymphocytotoxins (LCT). There was no difference in the prevalence of LCT in multiple myeloma, macroglobulinemia, cancer, lymphoma or benign monoclonal gammopathy. Prevalence of LCT was similar in various classes and types of...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206328
更新日期:1985-01-01 00:00:00
abstract::The short-term effect of a domestically produced equine antithymocyte globulin (ATG) was analyzed in 6 patients with acquired severe aplastic anemia (AA). All patients received 5 doses of ATG every other day in a 60-min intravenous infusion. Five peripheral blood immunoregulatory mononuclear cell (MNC) subsets, define...
journal_title:Acta haematologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000205557
更新日期:1989-01-01 00:00:00