Abstract:
:12 thalassaemic patients from Northern Sardinia showing the beta + phenotype were examined by isoelectric focusing and high-performance liquid chromatography techniques for the determination of the variant A gamma T globin chain of the foetal haemoglobin. Two patients (16.7%) were homozygotes for the A gamma T gene variant, 2 (16.7%) were heterozygotes and 8 (66.7%) were homozygotes for the normal A gamma I allele. The A gamma T gene frequency was 0.183, much lower than the observed 0.823 in beta zero homozygosity. These data suggest the presence of at least 2 beta +-thalassaemic chromosomes in Sardinians, one associated with the variant A gamma T allele and one associated with the normal A gamma I. The latter is prevalent among adult patients showing the intermediate form of the thalassaemic disease, which is not transfusion-dependent.
journal_name
Acta Haematoljournal_title
Acta haematologicaauthors
Masala B,Formato M,Manca L,Demuro P,Gallisai D,Dore F,Longinotti Mdoi
10.1159/000206057subject
Has Abstractpub_date
1986-01-01 00:00:00pages
208-11issue
4eissn
0001-5792issn
1421-9662journal_volume
76pub_type
杂志文章abstract::We have been studying hematopoietic effects by the tachykinins, which like many other neuropeptides can be expressed in neural and nonneural tissues. Substance P (SP) and neurokinin-A (NK-A), members of the tachykinins are immune and hematopoietic modulators. SP and NK-A are derived from the preprotachykinin-I gene (P...
journal_title:Acta haematologica
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abstract::Afibrinogenaemia in a female Saudi child is reported. Two siblings died of bleeding. The parents, who are first cousins, a brother and two sisters are asymptomatic heterozygotes with fibrinogen levels of less than 1.5 g/l. The presentation was described and compared to other cases reported. ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206624
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journal_title:Acta haematologica
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abstract::Allogeneic stem cell transplantation (SCT) is the treatment of choice for selected patients with chronic myeloid leukemia (CML). However, it is associated with a high risk of treatment-related mortality (TRM) and morbidity. To assist in decision making about transplantation, a simple scoring system to assess the risk ...
journal_title:Acta haematologica
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doi:10.1159/000069283
更新日期:2003-01-01 00:00:00
abstract::A 38-year-old Japanese man had suffered from trichophyton infection for several years. The white blood cell count was 20,300/mm3, including 54% abnormal lymphocytes with irregularly convoluted nuclei. Adult T-cell leukemia (ATL) was diagnosed based on proliferation of CD4-positive lymphocytes, positive anti-HTLV-I ant...
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更新日期:1992-01-01 00:00:00
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journal_title:Acta haematologica
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journal_title:Acta haematologica
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
abstract::Immunoglobulin light chain amyloidosis (AL amyloidosis) is a rare, life-threatening disease characterized by the deposition of misfolded proteins in vital organs such as the heart, the lungs, the kidneys, the peripheral nervous system, and the gastrointestinal tract. This causes a direct toxic effect, eventually leadi...
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pub_type: 杂志文章,评审
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journal_title:Acta haematologica
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更新日期:1990-01-01 00:00:00
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journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000203996
更新日期:1995-01-01 00:00:00
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journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206218
更新日期:1985-01-01 00:00:00
abstract::High-dose gammaglobulin therapy for patients with idiopathic thrombocytopenic purpura (ITP), introduced by Imbach et al., was applied to 5 adults with chronic refractory ITP to investigate the mechanism of the increase in platelet counts. In 4 of the 5 cases, transient increase in platelet count was observed. Platelet...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206927
更新日期:1983-01-01 00:00:00
abstract::Iron deficiency is the main cause of anemia in both sexes, with women being more commonly affected. Iron therapy is currently considered an effective and safe remedy to replenish the iron storages. Iron can be administrated both orally and intravenously. In particular, intravenous (IV) iron therapy is widely used when...
journal_title:Acta haematologica
pub_type:
doi:10.1159/000503768
更新日期:2020-01-01 00:00:00
abstract::A patient with regional enteritis had received iron dextran for treatment of iron deficiency. Subsequently he developed a large (3.1 g/100 ml) IgG-K serum spike which had precipitin activity against dextran sulfate but not a variety of other antigens. There has been no evidence of multiple myeloma and the spike gradua...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207755
更新日期:1978-01-01 00:00:00
abstract::Recent molecular biological investigations have shown that genetic information on the short arm of chromosome 17 is frequently deleted or inactivated in acute myeloid leukaemias and a number of solid tumours. In earlier studies we have found clonal occurrence of a 17p deletion (17p-) in patients with refractory anaemi...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205033
更新日期:1990-01-01 00:00:00
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journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000208052
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:This study aimed to compare the curative effects of the combination therapy of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO, As₂O₃) with ATRA monotherapy on newly diagnosed acute promyelocytic leukemia (APL). METHODS:The studies were retrieved from PubMed, EMBASE, Cochrane Library, ChinaInfo and...
journal_title:Acta haematologica
pub_type: 杂志文章,meta分析
doi:10.1159/000369242
更新日期:2015-01-01 00:00:00
abstract::A new deletion of the beta-globin gene cluster was characterized in a Turkish family. A 6-year-old male and his father were heterozygotes for this deletion. They presented with mild hypochromic microcytic anemia associated with elevated Hb F (15%) and normal Hb A2 levels (2.0%). This newly described Turkish type (delt...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000203790
更新日期:1996-01-01 00:00:00
abstract::A case of steroid-resistant acquired pure red-cell aplasia associated with a relative and absolute increase of TG cells is described. Removal of T cells enhanced erythroid colony and burst formation in vitro, and it is suggested that TG cells may be implicated in the pathogenesis of this case of acquired pure red-cell...
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pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
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journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000320169
更新日期:2010-01-01 00:00:00
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journal_title:Acta haematologica
pub_type: 临床试验,杂志文章
doi:10.1159/000040974
更新日期:1999-01-01 00:00:00
abstract::We report a patient with lung cancer who developed CD56-positive acute lymphoblastic leukemia. He was referred to our hospital for thrombocytopenia. Atypical cells were found in the blood and the bone marrow. These cells were immunophenotypically positive for CD3epsilon, CD56, and terminal deoxynucleotidyl transferase...
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更新日期:2005-01-01 00:00:00
abstract::Of 34 patients with chronic inflammatory bowel disease (CIBD), 4 developed well-documented episodes of deep-venous thrombosis. All 4 patients had active disease at the time of thrombosis. This group was studied to determine if the tendency to deep-venous thrombosis in patients with CIBD was associated with reduced ant...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206688
更新日期:1983-01-01 00:00:00
abstract::Neurologic complications of allogeneic hematopoietic cell transplantation (allo-HCT) include infections, cerebrovascular events, therapy-induced neurotoxicity, recurrent malignancies, and neurologic manifestations of graft-versus-host disease (GVHD). Anti-glutamic acid decarboxylase (GAD) antibody-associated cerebella...
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pub_type: 杂志文章
doi:10.1159/000494423
更新日期:2019-01-01 00:00:00
abstract::We have used the gel retardation assay to investigate the binding of nuclear proteins to the duplicated CACCC boxes in the beta-globin gene promoter region. The effect of beta-thalassemia mutations affecting both of these consensus sequences (the -88 C-->T and -101 C-->T mutations) were studied by using appropriate mu...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204237
更新日期:1994-01-01 00:00:00
abstract::Contamination of autologous graft by tumor, in addition to incomplete tumor eradication, can partly explain why relapse remains the commonest cause of treatment failure after autologous stem cell transplantation (ASCT) in patients with malignant hematologic disorders. Monitoring of minimal residual disease (MRD) is no...
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pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
abstract::In 33 children with cyanotic congenital heart disease the platelet function has been studied. The most significant changes were reduced platelet adhesiveness to glass and impaired availability of platelet factor 3 in nearly 50% of the patients. Although clot retraction was poor in 84% of them, thrombocytopenia and pro...
journal_title:Acta haematologica
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更新日期:1976-01-01 00:00:00
abstract::The transcription factors GATA-1 and GATA-2 play key roles in gene regulation during erythropoiesis. Gene ablation studies in mouse revealed that GATA-2 is crucial for the maintenance and proliferation of immature hematopoietic progenitors, whereas GATA-1 is essential for the survival of erythroid progenitors as well ...
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pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
abstract::The effect of total-body cold exposure on plasma concentrations of von Willebrand factor (vWF), endothelin-1 (ET) and thrombomodulin (TM), all of which are considered to be generated from the endothelium, was studied in systemic lupus erythematosus (SLE) patients with and without Raynaud's phenomenon. The plasma level...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204684
更新日期:1992-01-01 00:00:00