Immune Mediated Cerebellar Ataxia: An Unknown Manifestation of Graft-versus-Host Disease.

Abstract:

:Neurologic complications of allogeneic hematopoietic cell transplantation (allo-HCT) include infections, cerebrovascular events, therapy-induced neurotoxicity, recurrent malignancies, and neurologic manifestations of graft-versus-host disease (GVHD). Anti-glutamic acid decarboxylase (GAD) antibody-associated cerebellar ataxia is a well-established disorder of autoimmune origin, but there are no reports in the literature of its occurrence following allo-HCT. We describe a middle-aged woman with chronic GVHD after allo-HCT who presented with a rapidly progressive cerebellar syndrome. Thorough investigation revealed only cerebellar atrophy on brain imaging and positive anti-GAD65 antibodies in serum and cerebrospinal fluid suggesting the diagnosis of anti-GAD antibody-associated cerebellar ataxia. Despite prompt treatment with high-dose corticosteroids, intravenous immunoglobulins, and rituximab, the patient's condition rapidly deteriorated, and she died 4 months later. This case suggests that anti-GAD antibody-associated cerebellar ataxia may be a rare manifestation of chronic GVHD.

journal_name

Acta Haematol

journal_title

Acta haematologica

authors

Shargian-Alon L,Raanani P,Rozovski U,Siegal T,Yust-Katz S,Yeshurun M

doi

10.1159/000494423

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

19-22

issue

1

eissn

0001-5792

issn

1421-9662

pii

000494423

journal_volume

141

pub_type

杂志文章
  • The distribution of B and T lymphocytes in the peripheral blood of patients with Hodgkin's disease.

    abstract::The distribution of thymus-dependent (T cells) and bone marrow-derived lymphocytes (B cells) was studied in 74 patients with Hodgkin's disease and 33 normal controls. A T cell deficit was found in untreated patients as well as in long-term survivors in remission. Therapy slightly enhanced the T cell depletion in Hodgk...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000207911

    authors: Many A,Biniaminov M,Rosenthal E,Aghai E,Ramot B

    更新日期:1976-01-01 00:00:00

  • Human urinary erythropoietin: preparation with high potency.

    abstract::Human urinary erythropoietin has been purified to homogeneity. The seven-step procedure yielded a preparation with a potency of 225,000 U/mg protein. SDS-polyacrylamide gel electrophoretic analysis of the purified hormone revealed a single protein band with a molecular weight of about 35,000 that migrated with the bio...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000205057

    authors: Matsushita J,Kawakita M,Shibuya K,Koishihara Y,Sakaguchi M,Takatsuki A

    更新日期:1990-01-01 00:00:00

  • Serum levels of G-CSF, IL-3, IL-6 and GM-CSF after a single intraperitoneal dose of rhG-CSF in lethally irradiated B6D2F1 mice.

    abstract::The objective of this study was to assess the pharmacokinetics of rhG-CSF after a single intraperitoneal injection 2 h post-TBI in B6D2F1 lethally irradiated mice and to analyze the effect of rhG-CSF on the endogenous response of interleukin-3 (IL-3), interleukin-6 (IL-6) and granulocyte-macrophage colony-stimulating ...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000203604

    authors: Kádár E,Sureda A,Mangues MA,Inglés-Esteve J,Valls A,García J

    更新日期:1997-01-01 00:00:00

  • Normal levels of antithrombin III in acute leukemia complicated by coagulopathy.

    abstract::A patient with acute monoblastic leukemia developed a coagulopathy during chemotherapy. Coagulation studies showed thrombocytopenia, hypofibrinogenemia, high levels of fibrinogen degradation products, a negative protemine test but a normal antithrombin III level. These observations suggest that coagulation abnormaliti...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000207433

    authors: Vellenga E,Mulder NH

    更新日期:1980-01-01 00:00:00

  • Transmission and scanning electron microscopy study on congenital dyserythropoietic anemia type I.

    abstract::An ultrastructural study of the aspirated bone marrow of a patient with congenital dyserythropoietic anemia type I is presented. Both in transmission electron microscopy (TEM) and in scanning electron microscopy (SEM) ultrastructural abnormalities of the bone marrow erythroid precursors were seen. These abnormalities ...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000206735

    authors: Conde E,Mazo E,Baro J,Lafarga M,Cuadrado MA,Recio M,Zubizarreta A

    更新日期:1983-01-01 00:00:00

  • Ubiquitous expression of a cloned murine thymopoietin cDNA.

    abstract::Thymopoietin (TP) was originally isolated as a 5-kD 49-aa protein from bovine thymus and was subsequently observed to affect T-cell differentiation and function. We report here the molecular cloning of a murine TP cDNA. The 2,514 bp fragment contains a 630 bp open reading frame that encodes for 210 aa, highly homologo...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000203673

    authors: Theodor L,Shoham J,Berger R,Gokkel E,Trachtenbrot L,Simon AJ,Brok-Simon F,Nir U,Ilan E,Zevin-Sonkin D,Friedman E,Rechavi G

    更新日期:1997-01-01 00:00:00

  • In vivo models of thrombogenic potential: usefulness and limitations.

    abstract::The thrombogenicity of prothrombin complex concentrates (PCCs) has been known as a risk factor since their first clinical use about 30 years ago. The development of in vivo models to define the thrombogenic components in PCCs was instrumental in providing a logical basis for selecting in vitro assays to screen for the...

    journal_title:Acta haematologica

    pub_type: 杂志文章,评审

    doi:10.1159/000204039

    authors: MacGregor I,McLaughlin L,Drummond O,Prowse C,Ferguson J

    更新日期:1995-01-01 00:00:00

  • A new Hb variant: Hb F Sardinia gamma75(E19) isoleucine leads to threonine found in a family with Hb G Philadelphia, beta-chain deficiency and a Lepore-like haemoglobin indistinguishable from Hb A2.

    abstract::A 59-year-old man with beta-thalassaemia major is unusually well. He has no beta-chains in his haemoglobin but is heterozygous for the genes responsible for alphaA and for alphaG Philadelphia. In addition he is also heterozygous for the genes responsible for gammaF and a new gamma-chain, gamma75(E19) Ile-Thr, named ga...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000208204

    authors: Grifoni V,Kamuzora H,Lehmann H,Charlesworth D

    更新日期:1975-01-01 00:00:00

  • Thalassemia major and sickle cell disease in adolescents and young adults.

    abstract::The increased longevity of patients with thalassemia and sickle cell disease (SCD) introduces new clinical challenges due to the accumulation of disease-related morbidity, psychosocial issues and health care adjustments. Patients with thalassemia major now live into adulthood without suffering heart failure but must c...

    journal_title:Acta haematologica

    pub_type: 杂志文章,评审

    doi:10.1159/000360235

    authors: Yacobovich J,Tamary H

    更新日期:2014-01-01 00:00:00

  • Future directions in haematology: beyond multiple myeloma.

    abstract::Thalidomide acts on the microenvironment of myelodysplastic syndromes (MDS) by influencing cytokine networks, and growing evidence supports thalidomide's usefulness in the management of haematological malignancies, such as MDS. The European Collaboration Group on Myelofibrosis with Myeloid Metaplasia reviewed patients...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000087042

    authors: Prentice HG,Sacchi S,Russell N

    更新日期:2005-01-01 00:00:00

  • Spontaneous formation of megakaryocyte progenitors (CFU-MK) in primary thrombocythaemia.

    abstract::An improved plasma clot culture method for CFU megakaryocytes (MK) has been developed with a higher plating efficiency and easier identification and enumeration of MK colonies by an indirect immunoperoxidase staining using a monoclonal antibody specific to the platelet glycoprotein IIb/IIIa complex. This technique has...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000205837

    authors: Han ZC,Brière J,Abgrall JF,Sensèbe L,Nedellec G,Parent D,Guern G

    更新日期:1987-01-01 00:00:00

  • Aspergillus vegetative endocarditis complicated with schizocytic hemolytic anemia in a patient with acute lymphocytic leukemia.

    abstract::Aspergillus vegetative endocarditis developing in a patient with acute lymphocytic leukemia during the phase of hematological remission has led to a fatal outcome, complicated with severe hemolytic anemia with red cell fragmentation. Systemic aspergillosis may involve heart valves with underlying disorders, but seldom...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000206021

    authors: Nishiura T,Miyazaki Y,Oritani K,Tominaga N,Tomiyama Y,Katagiri S,Kanayama Y,Yonezawa T,Tarui S,Yamada T

    更新日期:1986-01-01 00:00:00

  • Motility of leukaemic cells in acute leukaemia related to tumour mass, maturation and FAB classification.

    abstract::In a group of 56 patients with acute leukaemia, the relation between leukaemic cell motility and peripheral leukaemic cell count, degree of organomegaly, maturation and FAB classification was investigated. Cell motility was studied by means of directly observed motility and scoring of handmirror cells and anti-HLA-cap...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000205595

    authors: van der Weide M,Imandt LM,Langenhuijsen MM

    更新日期:1988-01-01 00:00:00

  • Changes in the mitogenic activity of platelet-derived growth factor(s) in patients with myeloproliferative disease.

    abstract::Platelet-derived growth factor (PDGF) is thought to take part in the genesis of bone marrow fibrosis that can be found in patients with myeloproliferative diseases. We evaluated platelet mitogenic activity as the difference between serum and plasma activity in 8 patients with myeloproliferative disease. We observed a ...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000205544

    authors: Caenazzo A,Pietrogrande F,Polato G,Piva E,Masiero M,Sgarabotto D,Girolami A

    更新日期:1989-01-01 00:00:00

  • Two cases of ampulla (takotsubo-shaped) cardiomyopathy associated with hemophagocytic lymphohistiocytosis.

    abstract::There have been many reports of patients with ampulla cardiomyopathy described as takotsubo-shaped cardiomyopathy in the cardiovascular field. This unique cardiomyopathy is characterized by transient apical ballooning and hypokinesis of the left ventricle. We describe 2 cases of ampulla cardiomyopathy associated with ...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000098461

    authors: Takeoka Y,Nakamae M,Nakamae H,Hagihara K,Sakamoto E,Nakane T,Koh H,Koh KR,Ohta K,Yamane T,Hino M

    更新日期:2007-01-01 00:00:00

  • Eosinophilic gastroenteritis or eosinophilic chloroma?

    abstract::Granulocytic sarcoma of the small intestine preceding or as the presenting feature of acute myelogenous leukemia with chromosome 16 abnormalities has been observed in at least 4 patients. We report the case of a patient initially diagnosed with eosinophilic gastroenteritis, responding to corticosteroid treatment for 2...

    journal_title:Acta haematologica

    pub_type: 杂志文章,评审

    doi:10.1159/000079729

    authors: Julia A,Nomdedeu JF

    更新日期:2004-01-01 00:00:00

  • High-voltage irradiation and hydroxyurea for pulmonary leukostasis in acute myelomonocytic leukemia.

    abstract::A 29-year-old man with acute myelomonocytic leukemia had an initial leukocyte count of 192 X 10(9) cells/l and 84% blasts. During the initial treatment with hydroxyurea, 1 g/m2 orally tid, he developed pulmonary leukostasis which responded rapidly to whole-lung radiation with 1.5 Gy in one fraction. Pulmonary leukosta...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000205987

    authors: von Eyben FE,Siddiqui MZ,Spanos G

    更新日期:1987-01-01 00:00:00

  • Marrow suppression produced by repeated doses of cladribine.

    abstract::2-Chlorodeoxyadenosine (cladribine, Leustatin) is being used extensively in the treatment of hematologic malignancies, but relatively little is known regarding its toxicity to the normal marrow. Long-term serial hematologic observations have been made on 29 patients with multiple sclerosis undergoing experimental ther...

    journal_title:Acta haematologica

    pub_type: 临床试验,杂志文章

    doi:10.1159/000204236

    authors: Beutler E,Koziol JA,McMillan R,Sipe JC,Romine JS,Carrera CJ

    更新日期:1994-01-01 00:00:00

  • Acute promyelocytic leukemia in childhood. Report of a case with a review of the literature.

    abstract::A rare case of acute promyelcytic leukemia (APL) is reported in a 7-year-old boy. The patient displayed the typical features of APL including impaction of the marrow with promyelocytes, marked elevation of the serum vitamin B12 and transcobalamin I levels and a hemorrhagic diathesis. The bleeding diathesis in the case...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000207589

    authors: Engelhard D,Yatziv S,Rachmilewitz EA,Polliack A

    更新日期:1979-01-01 00:00:00

  • Thrombomodulin and von Willebrand factor: relation to endothelial dysfunction and disease outcome in children with acute lymphoblastic leukemia.

    abstract::The severe endothelial dysfunction in children with acute lymphoblastic leukemia (ALL) can result from the disease itself, from treatment, or from other conditions (e.g. sepsis). The aim of this study was to determine the levels of markers of endothelial activation in children with ALL and to assess their potential pr...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000322120

    authors: Hatzipantelis ES,Athanassiou-Metaxa M,Gombakis N,Tzimouli V,Taparkou A,Sidi-Fragandrea V,Garipidou V,Papageorgiou T,Kleta D,Koliouskas DE,Athanasiadou-Piperopoulou F

    更新日期:2011-01-01 00:00:00

  • Antibodies to human immunodeficiency virus (HTLV-III/LAV) in people from Lagos and Cross River States of Nigeria.

    abstract::Using enzyme-linked immunosorbent assay (ELISA) and confirmatory immunoprecipitation tests, sera from 640 Nigerians from Lagos and Cross River States were examined for antibodies against HIV. These comprised 570 blood donors and their family members, 56 patients with various haematological conditions and 14 patients w...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000205728

    authors: Okpara RA,Akinsete I,Williams EE,Schneider J,Wendler I,Hunsmann G

    更新日期:1988-01-01 00:00:00

  • Elevations of Thrombotic Biomarkers in Hemoglobin H Disease.

    abstract:BACKGROUND:Thalassemia is a group of hereditary hemoglobinopathies caused by decreased or absent synthesis of α and/or β globin chains. Studies have shown that hypercoagulability and thrombosis are common clinical symptoms in β-thalassemia, especially β-thalassemia intermedia, but little is known about in α-thalassemia...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000486157

    authors: Chansai S,Fucharoen S,Fucharoen G,Jetsrisuparb A,Chumpia W

    更新日期:2018-01-01 00:00:00

  • Autotransfusion of 3H-cytidine-labelled blood lymphocytes in patients with Hodgkin's disease and non-Hodgkin patients. II. Exchangeable lymphocyte pools.

    abstract::The dilution in the circulating blood of lymphocytes lablled in vitro with 3H-cytidine was examined after autotransfusion in 9 patients with Hodgkin's disease (HD) stage II A-IV B, 5 of whom were untreated; in 2 untreated patients with carcinoma, and in 1 treated patient with scleroderma. The blood transit time of exc...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000208185

    authors: Schick P,Trepel F,Eder M,Matzner M,Benedek S,Theml H,Kaboth W,Begemann H,Fliedner TM

    更新日期:1975-01-01 00:00:00

  • Factor VIII epitopes recognized with inhibitory monoclonal antibodies.

    abstract::To test whether anti-idiotypic immunoregulation of factor VIII(FVIII)-inhibiting antibodies could be feasible in hemophiliacs, we assayed the minimal number and range of immunogenic, functional FVIII epitopes to which a series of murine anti-FVIII monoclonal antibodies (MAb) were directed. Rabbit anti-idiotypic sera t...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000205171

    authors: Tiarks CY,Humphreys RE,Pechet L

    更新日期:1990-01-01 00:00:00

  • Thrombopoietin activity in mice following immune-induced thrombocytopenia.

    abstract::Thrombopoietin levels in thrombocytopenic mice assayed by 75Se-se-lenomethionine incorporation into blood platelets reached a maximum 12 h after the induction of an acute, immune thrombocytopenia; that was more than twice the value in control mice. The implications of this finding are discussed with reference to the k...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000208096

    authors: Nakeff A,Roozendaal KJ

    更新日期:1975-01-01 00:00:00

  • Avascular necrosis of the femoral head in sickle cell syndrome: a report of 5 cases.

    abstract::The course and management of avascular necrosis of the femoral head (AVNFH) in six hips of 5 sickle cell syndrome patients (3 with Hb SS, 1 with Hb SC and 1 with Hb S/beta+-thalassaemia) are described. Two patients (aged 13 and 17 years) presented with Perthes- and osteochondritis dessicans-type lesions. These hips pr...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000205873

    authors: Rand C,Pearson TC,Heatley FW

    更新日期:1987-01-01 00:00:00

  • Skin window cellularity and macrophage changes in Hodgkin's and non-Hodgkin's lymphomas.

    abstract::The cutaneous inflammatory response in patients with Hodgkin's and non-Hodgkin's lymphomas was investigated by light and scanning electron microscopy and compared with that of healthy subjects at 24 and 48 h. Both groups of patients showed a reduction in overall cellularity and statistically significant differences in...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000207253

    authors: Sokol RJ,Durrant TE,Hudson G

    更新日期:1980-01-01 00:00:00

  • Transient regression in lymphocyte count in B-cell chronic lymphocytic leukemia after viral infection.

    abstract::Transient regression in the lymphocyte count of a patient with B-cell chronic lymphocytic leukemia (B-CLL) after viral infection is reported. A similar event occurred under natural interferon-alpha (IFN-alpha) treatment. It was confirmed that the event was not caused by a direct cytotoxic effect of IFN-alpha by analyz...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000204091

    authors: Shirono K,Ikebe M,Inada T,Tsuda H

    更新日期:1995-01-01 00:00:00

  • Molecular findings and classification of malignant lymphomas.

    abstract::We review the problem of lymphoma classification in the light of the Revised European-American Lymphoma (REAL) scheme, recently proposed by the International Lymphoma Study Group (ILSG). The REAL classification is a list of clinicopathologic entities, all well known from the literature, upon which the ILSG members agr...

    journal_title:Acta haematologica

    pub_type: 杂志文章,评审

    doi:10.1159/000203875

    authors: Pileri SA,Ceccarelli C,Sabattini E,Santini D,Leone O,Damiani S,Leoncini L,Falini B

    更新日期:1996-01-01 00:00:00

  • Avascular necrosis of the hip in children with sickle cell disease and high Hb F: magnetic resonance imaging findings and influence of alpha-thalassemia trait.

    abstract::Avascular necrosis (AVN) of the hip is a common cause of morbidity in sickle cell disease (SCD). Its prevalence increases with age and predisposing factors include coexistent alpha-thalassemia trait, frequent vaso-occlusive crisis and a high hematocrit (Hct). SCD is relatively mild among Kuwaiti patients because of th...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000046529

    authors: Adekile AD,Gupta R,Yacoub F,Sinan T,Al-Bloushi M,Haider MZ

    更新日期:2001-01-01 00:00:00