Desensitization in Iron Product Allergy.

Abstract:

:Iron deficiency is the main cause of anemia in both sexes, with women being more commonly affected. Iron therapy is currently considered an effective and safe remedy to replenish the iron storages. Iron can be administrated both orally and intravenously. In particular, intravenous (IV) iron therapy is widely used when oral iron preparations are either not tolerated or ineffective. Indeed, IV iron improves iron stores more rapidly. Two main immunological responses have been described for iron hypersensitivity reactions (HSRs): IgE-mediated allergy and complement activation-related pseudo-allergy. Here, we report 3 cases of adult patients with iron allergy, who were successfully treated with two different desensitization procedures, respectively. Analysis of these cases demonstrates that, in the presence of HSRs to iron products, desensitization is an effective and safe procedure that prevents treatment discontinuation and hence allows therapeutic target achievement.

journal_name

Acta Haematol

journal_title

Acta haematologica

authors

Di Girolamo A,Albanesi M,Loconte F,Di Bona D,Caiaffa MF,Macchia L

doi

10.1159/000503768

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

496-499

issue

5

eissn

0001-5792

issn

1421-9662

pii

000503768

journal_volume

143

pub_type

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