Probable acenocoumarol-amoxycillin interaction.

Abstract:

:We present the case of a woman undergoing treatment with acenocoumarol for deep vein thrombosis, who maintained an international normalized ratio (INR) of between 2.5 and 4 for 2 months. Seven days after the introduction of amoxycillin (500 mg/8 h) for a probable respiratory infection, the patient developed spontaneous bruising, with an INR of 7.1. Treatment with amoxycillin was discontinued, and 3 weeks later the INR had returned to previous values. In this case, the increase in the INR value with associated bruising after the addition of amoxycillin suggests a drug interaction between acenocoumarol and amoxycillin, other possible causes having been eliminated.

journal_name

Acta Haematol

journal_title

Acta haematologica

authors

Soto J,Sacristan JA,Alsar MJ,Fernandez-Viadero C,Verduga R

doi

10.1159/000204457

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

195-7

issue

4

eissn

0001-5792

issn

1421-9662

journal_volume

90

pub_type

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