Marrow suppression produced by repeated doses of cladribine.

abstract：:2 cases of acute myeloid leukaemia with inclusion bodies are presented. The inclusions were found mainly in the blast cells but could also be encountered in lymphocytes and plasma cells. Cytochemical and ultrastructural studies showed a great resemblance of these inclusions to the ones found in Chediak-Higashi anomaly...

journal_title：Acta haematologica

authors： Efrati P,Nir E,Kaplan H,Dvilanski A

更新日期：1979-01-01 00:00:00

abstract：:A 51-year-old male with acute lymphoblastic leukemia whose course was complicated by primary fibrinolysis and spontaneous rupture of the spleen is described. The patient was treated with various drug combinations: vincristine and prednisone, later by cytosine arabinoside and finally by prednisone, methotrexate and 6-m...

journal_title：Acta haematologica

authors： Gafter U,Mandel EM,Weiss S,Djaldetti M

更新日期：1976-01-01 00:00:00

abstract：:2 fatal cases of graft-versus-host disease (GvHD) occurred following blood product transfusions given to patients receiving standard chemotherapy for Hodgkin's disease. GvHD was established by HLA typing, clinical course, and compatible skin biopsy. 23 cases of GvHD following transfusion of blood products from normal ...

journal_title：Acta haematologica

authors： Burns LJ,Westberg MW,Burns CP,Klassen LW,Goeken NE,Ray TL,Macfarlane DE

更新日期：1984-01-01 00:00:00

abstract：:In evaluating hypoimmunoglobulinemia in a patient with nonsecretory myeloma, studies of in vitro immunoglobulin synthesis were performed during a 3-year period. Impaired polyclonal response to mitogen stimulation associated with excessive suppressor activity was demonstrable at diagnosis. Despite successful chemothera...

journal_title：Acta haematologica

authors： Shustik C,Michel R,Karsh J

更新日期：1988-01-01 00:00:00

abstract：:Of 34 patients with chronic inflammatory bowel disease (CIBD), 4 developed well-documented episodes of deep-venous thrombosis. All 4 patients had active disease at the time of thrombosis. This group was studied to determine if the tendency to deep-venous thrombosis in patients with CIBD was associated with reduced ant...

journal_title：Acta haematologica

authors： Ghosh S,Mackie MJ,McVerry BA,Galloway M,Ellis A,McKay J

更新日期：1983-01-01 00:00:00

abstract：:Fibroblast-like cells were grown from the bone marrow of acute lymphoblastic leukemia (ALL) patients before, during and off therapy. A diminished growth capacity was observed in cells from patients before and during therapy. In the three groups studied, differences were also observed in the effect of hydrocortisone on...

journal_title：Acta haematologica

authors： Bruzzone MS,Minguell JJ

更新日期：1985-01-01 00:00:00

abstract：:A patient with acute monoblastic leukemia developed a coagulopathy during chemotherapy. Coagulation studies showed thrombocytopenia, hypofibrinogenemia, high levels of fibrinogen degradation products, a negative protemine test but a normal antithrombin III level. These observations suggest that coagulation abnormaliti...

journal_title：Acta haematologica

authors： Vellenga E,Mulder NH

更新日期：1980-01-01 00:00:00

abstract：:Treating patients with hemophilia and inhibitors is often problematic. The presence of inhibitors negatively impacts the effectiveness of treatment to achieve hemostasis especially in patients with hemophilia B, owing mainly to allergic reactions to factor IX (FIX) concentrates and the low success rate of immune toler...

journal_title：Acta haematologica

authors： Uchida E,Komori K,Kurata T,Taki M,Sakashita K

更新日期：2020-07-22 00:00:00

abstract：:Herein, we describe a case of a female patient in whom B cell chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) were diagnosed simultaneously. She presented with anemia, thrombocytopenia and splenomegaly. Flow cytometry demonstrated two immunophenotypically distinct CD5-positive monoclonal B cell popul...

journal_title：Acta haematologica

authors： Kourelis TV,Kahl BS,Benn P,Delach JA,Bilgrami SF

更新日期：2011-01-01 00:00:00

abstract：:An increased bone marrow (BM) apoptosis is one of the mechanisms responsible for the ineffective hematopoiesis of myelodysplastic syndromes (MDS). It is controversial whether the excessive apoptosis in myelodysplasia predominantly involves the subset of progenitor cells or of maturing cells. We investigated the degree...

journal_title：Acta haematologica

authors： Pecci A,Travaglino E,Klersy C,Invernizzi R

更新日期：2003-01-01 00:00:00

abstract：:Platelet aggregation induced in vitro with ADP, adrenalin and ristocetin was tested in 7 patients with megakaryoblastic leukemia (MKL). All patients had normal or high platelet counts and presented with hemorrhagic diathesis including purpura ecchymosis and epistaxis. Platelet morphology was grossly abnormal and elect...

journal_title：Acta haematologica

authors： Berrebi A,Vorst E,Shtalrid M,Resnitzky P,Nir E

更新日期：1984-01-01 00:00:00

abstract：:Chromosomal aberrations in a case of atypic myeloproliferative syndrome are reported. The analysis was carried out on short-term cultures of sternal bone marrow with the ASG and fluorescence method. 90% of the metaphases studied showed pseudoliploidy: one of the chromosomes 12 was missing and one submedian marker chro...

journal_title：Acta haematologica

authors： Fleischmann T,Krizsa F

更新日期：1975-01-01 00:00:00

abstract：:Granulocytic sarcoma (GS) is a rare extramedullary tumor composed of immature myeloid cells. It is usually associated with leukemia or other myeloproliferative disorders, but can also occur without overt hematologic disease, i.e. in patients with a normal bone marrow and no history of acute myelogenous leukemia. This ...

journal_title：Acta haematologica

authors： Breccia M,Petti MC,Fraternali-Orcioni G,Monarca B,Latagliata R,D'Elia GM,Mandelli F,Pileri SA

更新日期：2000-01-01 00:00:00

abstract：:The maturation process of leukemic myelomonocytoid cells derived from peripheral blood of two typical cases of chronic myelomonocytic leukemia was investigated in vitro. In both cases, liquid culture of the leukemic cells in the presence or absence of 12-o-tetradecanoyl phorbol-13-acetate yielded either monocyte-macro...

journal_title：Acta haematologica

authors： Takuwa N,Kanegasaki S,Asano S,Tomita T,Nakayama E,Sato N,Shinohara T,Miwa S

更新日期：1984-01-01 00:00:00

abstract：:We present a case with the clinical and pathological impression of Ph1-positive chronic myelogenous leukemia in extramedullary blast crisis involving lymph nodes as demonstrated by morphological and cytogenetic studies. The hyperploid cell lines that were present in the lymph node were not present in the bone marrow. ...

journal_title：Acta haematologica

authors： Velasquez ET,Verma RS,Krishnamurthy M,Dosik H

更新日期：1985-01-01 00:00:00

abstract：:To characterize intracellular signaling in peripheral blood (PB) cells of acute myeloid leukemia (AML) patients undergoing pretransplant conditioning with CXCR4 inhibitor plerixafor, granulocyte colony-stimulating factor (G-CSF), and busulfan plus fludarabine (Bu+Flu) chemotherapy, we profiled 153 proteins in 33 funct...

journal_title：Acta haematologica

authors： Zeng Z,Liu W,Benton CB,Konoplev S,Lu H,Wang RY,Chen J,Shpall E,Baggerly KA,Champlin R,Konopleva M

更新日期：2019-01-01 00:00:00

abstract：:In 33 children with cyanotic congenital heart disease the platelet function has been studied. The most significant changes were reduced platelet adhesiveness to glass and impaired availability of platelet factor 3 in nearly 50% of the patients. Although clot retraction was poor in 84% of them, thrombocytopenia and pro...

journal_title：Acta haematologica

authors： Bhargava M,Sanyal SK,Thapar MK,Kumar S,Hooja V

更新日期：1976-01-01 00:00:00

abstract：:Fas/APO-1 (CD95) is a cell surface molecule that can transduce apoptotic signals into cells. We examined the expression of Fas antigen on CD4+ and CD8+ T cells of patients who received total body irradiation (TBI) as a preparative regimen for allogeneic bone marrow transplantation. Numbers of peripheral blood lymphocy...

journal_title：Acta haematologica

authors： Fujimori Y,Saheki K,Itoi H,Okamamoto T,Kakishita E

更新日期：2000-01-01 00:00:00

abstract：:We evaluated the results of high-dose therapy (HDT) and autologous hematopoietic stem cell transplantation (ASCT) in patients with relapsed or primary refractory Hodgkin's disease (HD), using a previously reported prognostic model based on the presence of three poor prognostic factors at the start of salvage therapy/p...

journal_title：Acta haematologica

authors： Qazilbash MH,Devetten MP,Abraham J,Lynch JP,Beall CL,Auber M,Weisenborn R,Bunner P,Ericson SG

更新日期：2003-01-01 00:00:00

abstract：:350 patients with idiopathic thrombocytopenic purpura (ITP) aged 2/12-15 years (mean 6.3 +/- 2.7) were followed up during the period January 1st, 1975 to March 31, 1992. They constituted 40% of cases with hemorrhagic diathesis attending the Hematology/Oncology Clinic, Children's Hospital, Ain Shams University (relativ...

journal_title：Acta haematologica

authors： Khalifa AS,Tolba KA,el-Alfy MS,Gadallah M,Ibrahim FH

更新日期：1993-01-01 00:00:00

abstract：:A variety of adhesion receptors are expressed on the blast cells in patients with acute myelogenous leukemia. The panel of receptors expressed demonstrates heterogeneity just as there is morphologic, histochemical, cytogenetic, and molecular genetic variation between various cases of acute myelogenous leukemia. The ad...

journal_title：Acta haematologica

authors： Liesveld JL

更新日期：1997-01-01 00:00:00

abstract：:The activity of gamma-glutamyl transpeptidase was investigated in normal and leukemia leukocytes. Enzyme activity was positively correlated with the proportion of mature neutrophils and monocytes. In isolated leukocytes from patients with acute myeloid leukemia low values were obtained compared to controls. ...

journal_title：Acta haematologica

authors： Hultberg B,Sjögren U

更新日期：1980-01-01 00:00:00

abstract：:Bone marrow fragments from 10 patients with a megaloblastic anaemia due to vitamin B12 or folate deficiency were studied by electron microscopy and electron microscope autoradiography. A proportion of the erythroblasts showed ultrastructural abnormalities. Some of the cells containing autophagic vacuoles, large sidero...

journal_title：Acta haematologica

authors： Wickramasinghe SN,Bush V

更新日期：1977-01-01 00:00:00

abstract：:In cutaneous T-cell lymphomas (CTCL; mycosis fungoides and Sézary syndrome), the standard therapies tend to be effective but not curative. Single drug therapy with either interferon-alpha or retinoids shows a response rate of about 45%. In this article, we report the results obtained in the treatment of CTCL with a co...

journal_title：Acta haematologica

authors： Dreno B,Celerier P,Litoux P

更新日期：1993-01-01 00:00:00

abstract：:A new variant of red cell glucose-6-phosphate dehydrogenase (G6PD) has been found in a Caucasian man with congenital non-spherocytic haemolytic anaemia. This variant has reduced activity, increased thermolability, increased Michaelis constants for glucose-6-phosphate and NADP, slightly increased electrophoretic mobili...

journal_title：Acta haematologica

authors： Mandelli F,Amadori S,De Laurenzi A,Kahn A,Isacchi G,Papa G

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVES:Reticulated platelets circulating in the blood reflect megakaryopoietic activity and platelet turnover and can be automatically and low-invasively measured as the immature platelet fraction (IPF) using a Sysmex XN hematocytometer. The present study retrospectively investigated whether or not the IPF can pred...

journal_title：Acta haematologica

authors： Takami A,Mizuno S,Nakamura A,Kanasugi J,Yamamoto H,Vu Quang L,Nakagami Y,Nakano Y,Yamada S,Matsumura S,Takasugi S,Uchino K,Horio T,Murakami S,Oohigashi Y,Nakayama T,Tani H,Enomoto M,Hanamura I

更新日期：2020-09-17 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to study the effect of vitamin E treatment in oxidative stress of red and white cells of beta-thalassaemia intermedia patients. METHODS:Nine patients undergoing occasional transfusions (5 females/4 males), median age 39 years (range 15-74), were recruited for oral daily admi...

journal_title：Acta haematologica

authors： Pfeifer WP,Degasperi GR,Almeida MT,Vercesi AE,Costa FF,Saad ST

更新日期：2008-01-01 00:00:00

abstract：:Hypercalcemia is a significant feature of patients with active multiple myeloma (MM) with extensive bone disease. Among the causes of non-neoplastic hypercalcemia, primary hyperparathyroidism (PHPT) is one of the most common, leading to osteoporosis and bone fractures. Interestingly, some preclinical data indicate tha...

journal_title：Acta haematologica

authors： Notarfranchi L,Marchica V,Dalla Palma B,Pelagatti L,Burroughs-Garcia J,Pedrazzoni M,Ruffini L,Cetani F,Marcocci C,Giuliani N

更新日期：2020-09-09 00:00:00

abstract：:Two patients with paraneoplastic cerebellar degeneration accompanying Hodgkin's disease were treated with plasma exchange in combination with chemotherapy or radiation therapy, respectively. Significant improvement in neurologic symptoms was obtained in 1 of them. ...

journal_title：Acta haematologica

authors： Cehreli C,Payzin B,Undar B,Yilmaz U,Alakavuklar MN

更新日期：1995-01-01 00:00:00

abstract：:We report a patient with lung cancer who developed CD56-positive acute lymphoblastic leukemia. He was referred to our hospital for thrombocytopenia. Atypical cells were found in the blood and the bone marrow. These cells were immunophenotypically positive for CD3epsilon, CD56, and terminal deoxynucleotidyl transferase...

journal_title：Acta haematologica

authors： Matano S,Terahata S,Nakamura S,Kobayashi K,Sugimoto T

更新日期：2005-01-01 00:00:00