Abstract:
:Hypercalcemia is a significant feature of patients with active multiple myeloma (MM) with extensive bone disease. Among the causes of non-neoplastic hypercalcemia, primary hyperparathyroidism (PHPT) is one of the most common, leading to osteoporosis and bone fractures. Interestingly, some preclinical data indicate that high secretion of parathyroid hormone (PTH) may have a negative impact on bone disease and MM progression. However, concomitant diagnosis of MM and PHPT has rarely been described. Here, we present 4 cases of patients with active MM and hypercalcemia with high or inappropriately normal PTH levels. Interestingly, CD138+ cells from these 4 MM patients lack PTH receptor 1 and PTH-related peptide expressions, indicating that PTH could have a paracrine rather than a direct pro-tumoral effect. Moreover, these cases suggest that the concomitant diagnosis of MM and PHTP may not be so rare and should be considered for the clinical management of MM patients with hypercalcemia.
journal_name
Acta Haematoljournal_title
Acta haematologicaauthors
Notarfranchi L,Marchica V,Dalla Palma B,Pelagatti L,Burroughs-Garcia J,Pedrazzoni M,Ruffini L,Cetani F,Marcocci C,Giuliani Ndoi
10.1159/000509768subject
Has Abstractpub_date
2020-09-09 00:00:00pages
1-6eissn
0001-5792issn
1421-9662pii
000509768pub_type
abstract::A variety of adhesion receptors are expressed on the blast cells in patients with acute myelogenous leukemia. The panel of receptors expressed demonstrates heterogeneity just as there is morphologic, histochemical, cytogenetic, and molecular genetic variation between various cases of acute myelogenous leukemia. The ad...
journal_title:Acta haematologica
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pub_type: 共识发展会议,杂志文章,评审
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journal_title:Acta haematologica
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doi:10.1159/000204653
更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-12-01 00:00:00
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更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:It is a common belief among women that iron compounds have unpleasant gastrointestinal side effects. OBJECTIVE:To assess the gastrointestinal side effects of iron prophylaxis in pregnancy. METHODS:A randomized, double-blind study comprising 404 healthy pregnant women allocated to four groups taking ferrous...
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:1975-01-01 00:00:00
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