Expression and function of adhesion receptors in acute myelogenous leukemia: parallels with normal erythroid and myeloid progenitors.

abstract：:We studied 14 adult patients presenting with fever and cytopenia of the peripheral blood and histiocytic hyperplasia with hemophagocytosis (HHH) in the bone marrow regarding an association of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) by using in situ hybridization (ISH) and also evaluated the clinical and lab...

journal_title：Acta haematologica

authors： Han K,Kim Y,Kahng J,Lee J,Moon Y,Kang C,Shim S

更新日期：1996-01-01 00:00:00

abstract：:We studied neutrophil chemotaxis and surface membrane glycoproteins in 12 patients suffering from myeloid disorders with abnormal karyotype using in vitro techniques in all 12. Chromosome studies were also carried out virtually simultaneously. We chose to study only patients showing a deficit of chemotaxis (p less tha...

journal_title：Acta haematologica

authors： Ricevuti G,Mazzone A,Notario A

更新日期：1989-01-01 00:00:00

abstract：:Fas/APO-1 (CD95) is a cell surface molecule that can transduce apoptotic signals into cells. We examined the expression of Fas antigen on CD4+ and CD8+ T cells of patients who received total body irradiation (TBI) as a preparative regimen for allogeneic bone marrow transplantation. Numbers of peripheral blood lymphocy...

journal_title：Acta haematologica

authors： Fujimori Y,Saheki K,Itoi H,Okamamoto T,Kakishita E

更新日期：2000-01-01 00:00:00

abstract：:A comparative study of karyotypes, hematological variables and neutrophil alkaline phosphatase (NAP) was performed in 106 parents (53 couples) of children with free, homogeneous trisomy 21 and of 220 parents (110 couples) of normal children. In the parents of trisomy 21 children we found a significant increase of the ...

journal_title：Acta haematologica

authors： Grozdea J,Bourrouillou G,Mounie C,Colombies P

更新日期：1980-01-01 00:00:00

abstract：:Downregulation of apoptosis has been proposed as a mechanism of clonal expansion in low-grade B cell neoplasms. We have previously described an unusual case of CD5+ B cell lymphoma characterized by cycles of leukemic phase alternating with spontaneous remission. In the present study, we examined the involvement of apo...

journal_title：Acta haematologica

authors： Aizman I,Many A,Peller S,Ramot B,Kaufmann Y

更新日期：2000-01-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a stem cell malignancy that originates in the bone marrow and involves the peripheral blood. Extramedullary AML is rarer, but it is most commonly associated with the former French-American-British (FAB) subtypes M4 or M5 of AML. AML cells may also home to the central nervous system and ...

journal_title：Acta haematologica

authors： Patel SA,Bledsoe JR,Gordon J,Cerny J

更新日期：2020-08-19 00:00:00

abstract：:Treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute leukemia (Ph+ ALL) has been revolutionized with the advent of tyrosine kinase inhibitors (TKIs). Most patients with CML achieve long-term survival similar to individuals without CML due to treatment with TKIs not only in frontline b...

journal_title：Acta haematologica

authors： Saussele S,Haverkamp W,Lang F,Koschmieder S,Kiani A,Jentsch-Ullrich K,Stegelmann F,Pfeifer H,La Rosée P,Goekbuget N,Rieger C,Waller CF,Franke GN,le Coutre P,Kirchmair R,Junghanss C

更新日期：2020-01-01 00:00:00

abstract：:Significant DNA polymorphisms have been reported in the beta-globin gene cluster of epsilon-G gamma-A gamma-psi beta-delta-beta-gene region, in normal (Hb AA) individuals and in patients with sickle cell anaemia (SCA). Investigations of the extent of the DNA polymorphisms in the beta A- and beta S-globin gene cluster ...

journal_title：Acta haematologica

authors： el-Hazmi MA,Bahakim HM,Warsy AS

更新日期：1992-01-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) is thought to take part in the genesis of bone marrow fibrosis that can be found in patients with myeloproliferative diseases. We evaluated platelet mitogenic activity as the difference between serum and plasma activity in 8 patients with myeloproliferative disease. We observed a ...

journal_title：Acta haematologica

authors： Caenazzo A,Pietrogrande F,Polato G,Piva E,Masiero M,Sgarabotto D,Girolami A

更新日期：1989-01-01 00:00:00

abstract：:Serum soluble interleukin-6 receptor (sIL-6R) concentrations were measured in 50 patients with plasma cell dyscrasias using a commercially available immunoenzymatic assay kit. There were 40 patients with multiple myeloma (MM), 5 patients with monoclonal gammopathy of undetermined significance (MGUS), 3 patients with s...

journal_title：Acta haematologica

authors： Papadaki H,Kyriakou D,Foudoulakis A,Markidou F,Alexandrakis M,Eliopoulos GD

更新日期：1997-01-01 00:00:00

abstract：:We have used the gel retardation assay to investigate the binding of nuclear proteins to the duplicated CACCC boxes in the beta-globin gene promoter region. The effect of beta-thalassemia mutations affecting both of these consensus sequences (the -88 C-->T and -101 C-->T mutations) were studied by using appropriate mu...

journal_title：Acta haematologica

authors： Baysal E,Ribeiro ML,Huisman TH

更新日期：1994-01-01 00:00:00

abstract：:Recombinant alpha-interferons are used as therapeutic agents in an increasing number of benign and malignant disorders. Long-term administration of recombinant alpha-interferon as a maintenance agent is associated with a small number of adverse side-effects which are responsible for patient intolerance of this drug. T...

journal_title：Acta haematologica

authors： Giles FJ,Worman CP,Jewell AP,Goldstone AH

更新日期：1991-01-01 00:00:00

abstract：:Preliminary results from the first 21 patients of a group of 30 with International Federation of Gynaecology and Obstetrics (FIGO) stage II-IV epithelial ovarian carcinoma and anaemia are reported. Patients entered this open-label, comparative-group, out-patient study and were randomized to receive conventional suppor...

journal_title：Acta haematologica

authors： James RD,Wilkinson PM,Belli F,Welch R,Cowan R

更新日期：1992-01-01 00:00:00

abstract：:The transcription factors GATA-1 and GATA-2 play key roles in gene regulation during erythropoiesis. Gene ablation studies in mouse revealed that GATA-2 is crucial for the maintenance and proliferation of immature hematopoietic progenitors, whereas GATA-1 is essential for the survival of erythroid progenitors as well ...

journal_title：Acta haematologica

authors： Ohneda K,Yamamoto M

更新日期：2002-01-01 00:00:00

abstract：:A 51-year-old male with acute lymphoblastic leukemia whose course was complicated by primary fibrinolysis and spontaneous rupture of the spleen is described. The patient was treated with various drug combinations: vincristine and prednisone, later by cytosine arabinoside and finally by prednisone, methotrexate and 6-m...

journal_title：Acta haematologica

authors： Gafter U,Mandel EM,Weiss S,Djaldetti M

更新日期：1976-01-01 00:00:00

abstract：:Primary lymphoma of the female genital tract is very rare. We report the case of a 36-year-old woman who was referred to our hospital because of an indeterminate Pap smear test. The colposcopy showed a thickening of the posterior vaginal wall and various irregular ulcerated nodular lesions. Histological examination, i...

journal_title：Acta haematologica

authors： Guastafierro S,Tedeschi A,Criscuolo C,Celentano M,Cobellis L,Rossiello R,Falcone U

更新日期：2012-01-01 00:00:00

abstract：:A case of steroid-resistant acquired pure red-cell aplasia associated with a relative and absolute increase of TG cells is described. Removal of T cells enhanced erythroid colony and burst formation in vitro, and it is suggested that TG cells may be implicated in the pathogenesis of this case of acquired pure red-cell...

journal_title：Acta haematologica

authors： Linch DC,Cawley JC,MacDonald SM,Masters G,Roberts BE,Antonis AH,Waters AK,Sieff C,Lydyard PM

更新日期：1981-01-01 00:00:00

abstract：:The detection of cellular antigens in bone marrow sections depends on the method of embedding, the nature of antigen and antibody, antigen retrieval techniques and the sensitivity of the immunohistochemical method. This study evaluated a fluorescyl-tyramide-enhanced immunostaining method on methyl-methacrylate-embedde...

journal_title：Acta haematologica

authors： Gaiser T,Bernhards J

更新日期：2007-01-01 00:00:00

abstract：:Fetal hemoglobin (HbF) concentrations were measured by a radial immunodiffusion assay in 233 patients with various malignancies. In 96 of these, alpha-fetoprotein (AFP) was also measured by radioimmunoassay. The concentration of HbF exceeded 2 SDs above the normal mean in 39 of 233 patients, most notably in patients w...

journal_title：Acta haematologica

authors： Chudwin DS,Rucknagel DL,Scholnik AP,Waldmann TA,McIntire KR

更新日期：1977-01-01 00:00:00

abstract：:Systematic reviews and meta-analyses have made a major contribution to the evidence-based management of infections in cancer patients. We review the contribution of systematic reviews with regard to antibiotic, antifungal, antiviral and Pneumocystis pneumonia prophylaxis; antibiotic and antifungal treatment of febrile...

journal_title：Acta haematologica

authors： Paul M,Gafter-Gvili A,Goldberg E,Yahav D

更新日期：2011-01-01 00:00:00

abstract：:A study was carried out of 332 babies suffering from severe neonatal jaundice who were admitted to the General Hospital, Kuala Lumpar, Malaysia. Of the 332 neonates, 51 were premature and 281 were full-term babies, 178 (110 Chinese, 58 Malay, 9 Indian and 1 European-Pakistani) had bilirubin levels of 20 mg% or higher,...

journal_title：Acta haematologica

authors： Lie-Injo LE,Virik HK,Lim PW,Lie AK,Ganesan J

更新日期：1977-01-01 00:00:00

abstract：:A 74-year-old woman was treated by lithium carbonate 3 x 300 mg per day for drug-induced aplastic anemia. After 8 days, she suddenly developed severe impairment of consciousness with myoclonias and hypertonia which persisted during 10 days despite lithium withdrawal and sodium chloride infusion. Slight disorders of wa...

journal_title：Acta haematologica

authors： Efira A,van Laethem Y,Ectors M,Unger J

更新日期：1980-01-01 00:00:00

abstract：:Gene therapy targeting hematopoietic cells has arrived at a new stage of potency. While the potential for curing inherited disorders of the immune system has been demonstrated in clinical trials, we were also confronted with the first serious adverse events related to random insertion of foreign DNA into cellular chro...

journal_title：Acta haematologica

authors： Baum C,von Kalle C

更新日期：2003-01-01 00:00:00

abstract：:Chronic pain affects 50% of adults with sickle cell disease (SCD). Although inflammation is thought to contribute to the pathogenesis of chronic pain, no studies have examined the differences in circulating cytokines between patients with SCD with and without chronic pain. We performed an observational cohort study us...

journal_title：Acta haematologica

authors： Karafin MS,Simpson P,Field JJ

更新日期：2021-01-01 00:00:00

abstract：:Monosomy 7 myelodysplasia is a rare hematological entity and is associated with morphological abnormalities in bone marrow and peripheral smear, and poor prognosis in children. We describe 2 children with infantile monosomy 7 myelodysplasia which evolved to leukemia. One of them died after 1 month, and the other is st...

journal_title：Acta haematologica

authors： Yeşilipek MA,Lüleci G,Velipaşaoğlu S,Berker S,Yeğin O

更新日期：1994-01-01 00:00:00

abstract：:We review the problem of lymphoma classification in the light of the Revised European-American Lymphoma (REAL) scheme, recently proposed by the International Lymphoma Study Group (ILSG). The REAL classification is a list of clinicopathologic entities, all well known from the literature, upon which the ILSG members agr...

journal_title：Acta haematologica

authors： Pileri SA,Ceccarelli C,Sabattini E,Santini D,Leone O,Damiani S,Leoncini L,Falini B

更新日期：1996-01-01 00:00:00

abstract：:Eleven patients with acute myeloid leukaemia (AML) in first complete remission (CR) were treated with alfa-2a-interferon (for short 'interferon') maintenance therapy, at a dose of 3 MU twice to thrice weekly subcutaneously. Adjustments were made to maintain neutrophil counts > 1 x 10(9)/l and platelet counts > 100 x 1...

journal_title：Acta haematologica

authors： McSweeney EN,Worman CP,Tsakona CP,Jewel AP,Hoffbrand AV,Milligan DW,Burnett AK,Lewis ML,Goldstone AH

更新日期：1993-01-01 00:00:00

abstract：:In a case of preleukemic dyserythropoiesis, in vitro red cell lysis tests showed a positive acidified serum test whose characteristics are described. The positive acidified serum test occurred in 10 normal sera, in 1 serum with complete deficiency of the fourth component of complement and in 1 serum with complete defi...

journal_title：Acta haematologica

authors： Hauptmann G,Sondag D,Lang JM,Oberling F

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Umbilical cord blood (UCB) contains haematopoietic stem cells and can be used as an alternative to bone marrow transplantation in certain cases. Engraftment was dependent upon the haematopoietic progenitor cell content of the cord blood units. This study was designed to investigate the influen...

journal_title：Acta haematologica

authors： Solves P,Perales A,Moraga R,Saucedo E,Soler MA,Monleon J

更新日期：2005-01-01 00:00:00

abstract：:The course and management of avascular necrosis of the femoral head (AVNFH) in six hips of 5 sickle cell syndrome patients (3 with Hb SS, 1 with Hb SC and 1 with Hb S/beta+-thalassaemia) are described. Two patients (aged 13 and 17 years) presented with Perthes- and osteochondritis dessicans-type lesions. These hips pr...

journal_title：Acta haematologica

authors： Rand C,Pearson TC,Heatley FW

更新日期：1987-01-01 00:00:00