Changes in the mitogenic activity of platelet-derived growth factor(s) in patients with myeloproliferative disease.

abstract：:In order to study the abnormal differentiation and proliferation of precursor T cells in homosexual men, a study was made of T-cell colony formation in 15 healthy homosexual men without anti-human immunodeficiency virus (HIV) antibody. The colony forming method used was the one-step monolayer technique using phytohema...

journal_title：Acta haematologica

authors： Wakabayashi Y,Sugimoto M,Ishiyama T,Hashimoto M,Horie S,Hirose S

更新日期：1989-01-01 00:00:00

abstract：:It is unusual to find microorganisms in peripheral blood smears, and their presence is frequently associated with overwhelming sepsis and consequently a poor prognosis. In this report, we demonstrate 4 cases with bacteria in blood smears. Two of them had a fatal outcome, but the other 2 were caused by a contamination ...

journal_title：Acta haematologica

authors： van der Meer W,Verwiel JM,Gidding CE,de Metz M,de Keijzer MH

更新日期：2002-01-01 00:00:00

abstract：:The 8p11 myeloproliferative syndrome (EMS) is an aggressive neoplasm associated with chromosomal translocations involving the fibroblast growth factor receptor 1 (FGFR1) tyrosine kinase gene on chromosome 8p11-12. A new case of a 9-year-old boy with leukocytosis, eosinophilia, and general lymphadenopathy is reported i...

journal_title：Acta haematologica

authors： Lv H,Hu S,Lu J,Zhai Q,Zhai Z,Du Z,Sun Y,Li J,He H,Wang Y

更新日期：2018-01-01 00:00:00

abstract：:Platelet aggregation in diabetic retinopathy was investigated in a group of 25 patients. An enhanced activity induced by epinephrine and arachidonic acid was found in this group as compared with the controls, whereas in adenosine diphosphate (ADP) platelet aggregation no differences were observed. Spontaneous aggregat...

journal_title：Acta haematologica

authors： Creter D,Pavlotzky F,Savir H

更新日期：1978-01-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to study the effect of vitamin E treatment in oxidative stress of red and white cells of beta-thalassaemia intermedia patients. METHODS:Nine patients undergoing occasional transfusions (5 females/4 males), median age 39 years (range 15-74), were recruited for oral daily admi...

journal_title：Acta haematologica

authors： Pfeifer WP,Degasperi GR,Almeida MT,Vercesi AE,Costa FF,Saad ST

更新日期：2008-01-01 00:00:00

abstract：:We present a case with the clinical and pathological impression of Ph1-positive chronic myelogenous leukemia in extramedullary blast crisis involving lymph nodes as demonstrated by morphological and cytogenetic studies. The hyperploid cell lines that were present in the lymph node were not present in the bone marrow. ...

journal_title：Acta haematologica

authors： Velasquez ET,Verma RS,Krishnamurthy M,Dosik H

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:Adherence to tyrosine kinase inhibitor treatment is a significant factor in the achievement of a good clinical response in chronic myeloid leukemia (CML). The aim of this retrospective study is to investigate 1- and 2-year medication adherence to imatinib treatment, linking adherence rates with the clinical o...

journal_title：Acta haematologica

authors： Santoleri F,Lasala R,Ranucci E,La Barba G,Di Lorenzo R,Vetrò A,Di Bartolomeo P,Costantini A

更新日期：2016-01-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a stem cell malignancy that originates in the bone marrow and involves the peripheral blood. Extramedullary AML is rarer, but it is most commonly associated with the former French-American-British (FAB) subtypes M4 or M5 of AML. AML cells may also home to the central nervous system and ...

journal_title：Acta haematologica

authors： Patel SA,Bledsoe JR,Gordon J,Cerny J

更新日期：2020-08-19 00:00:00

abstract：:We evaluated the iron status of 50 Sicilian patients with G6PD deficiency under steady-state conditions and compared our results with those for 50 control patients. We studied haemolysis and iron indices to evaluate the iron balance. These patients could be considered to be at risk of iron overload as a result of incr...

journal_title：Acta haematologica

authors： Ragusa R,Di Cataldo A,Gangarossa S,Lo Nigro L,Schilirò G

更新日期：1993-01-01 00:00:00

abstract：:A 59-year-old man with beta-thalassaemia major is unusually well. He has no beta-chains in his haemoglobin but is heterozygous for the genes responsible for alphaA and for alphaG Philadelphia. In addition he is also heterozygous for the genes responsible for gammaF and a new gamma-chain, gamma75(E19) Ile-Thr, named ga...

journal_title：Acta haematologica

authors： Grifoni V,Kamuzora H,Lehmann H,Charlesworth D

更新日期：1975-01-01 00:00:00

abstract：:The last few years have seen an enormous increase in our knowledge on the haematopoietic growth factor erythropoietin (Epo), firstly with its purification and determination of its primary amino acid sequence, and more recently with the isolation of the Epo gene and its expression in mammalian cell lines. This review a...

journal_title：Acta haematologica

authors： Foa P

更新日期：1991-01-01 00:00:00

abstract：:We studied neutrophil chemotaxis and surface membrane glycoproteins in 12 patients suffering from myeloid disorders with abnormal karyotype using in vitro techniques in all 12. Chromosome studies were also carried out virtually simultaneously. We chose to study only patients showing a deficit of chemotaxis (p less tha...

journal_title：Acta haematologica

authors： Ricevuti G,Mazzone A,Notario A

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Posterior reversible encephalopathy syndrome (PRES) is a rare but serious complication after allogeneic hematopoietic stem cell transplantation (alloHSCT). Among others, calcineurin inhibitors (CNI) for prophylaxis of graft-versus-host disease (GvHD) may promote the development of PRES, but the pathomechanis...

journal_title：Acta haematologica

authors： Schmidt V,Prell T,Treschl A,Klink A,Hochhaus A,Sayer HG

更新日期：2016-01-01 00:00:00

abstract：:Thymoma is an uncommon neoplasia derived from the epithelial cells of the thymus, which leads to immune dysregulation and is associated with a series of autoimmune diseases. However, the concurrence of these disease entities is rare, and the exact mechanisms of these diseases are still unclear. We have admitted severa...

journal_title：Acta haematologica

authors： Wang W,Chen LY,Zhao W,Ren Y,Wang L,Li X,Jiang Y,Gao H

更新日期：2020-01-01 00:00:00

abstract：:Aspirates from bone marrow, spleen and liver were morphologically analysed in 15 untreated patients wich chronic myeloid leukaemia. Megaloblastic changes of the erythroblasts were found to be more common in the spleen and liver than in the bone marrow. A significant increase of 'erythroblastic islands', i.e. erythrobl...

journal_title：Acta haematologica

authors： Sjögren U

更新日期：1976-01-01 00:00:00

abstract：:Treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute leukemia (Ph+ ALL) has been revolutionized with the advent of tyrosine kinase inhibitors (TKIs). Most patients with CML achieve long-term survival similar to individuals without CML due to treatment with TKIs not only in frontline b...

journal_title：Acta haematologica

authors： Saussele S,Haverkamp W,Lang F,Koschmieder S,Kiani A,Jentsch-Ullrich K,Stegelmann F,Pfeifer H,La Rosée P,Goekbuget N,Rieger C,Waller CF,Franke GN,le Coutre P,Kirchmair R,Junghanss C

更新日期：2020-01-01 00:00:00

abstract：:Platelet functions were evaluated in 20 healthy pregnant women in the last months of pregnancy, during labor, and 5-12 weeks after labor. The results showed an increased platelet count, bleeding time and nitroblue tetrazolium (NBT) test, as well as an increased plasma calcium level postlabor. ADP- and epinephrine-indu...

journal_title：Acta haematologica

authors： Sagi A,Creter D,Goldman J,Djaldetti M

更新日期：1981-01-01 00:00:00

abstract：:With the widespread use of genetic diagnostic technologies, many novel mutations have been identified in hereditary spherocytosis (HS)-related genes, including SPTA1, SPTB, ANK1, SLC4A1, and EPB42. However, mutations in HS-related genes are dispersed and nonspecific in the diagnosis of some HS patients, indicating sig...

journal_title：Acta haematologica

authors： He BJ,Liao L,Deng ZF,Tao YF,Xu YC,Lin FQ

更新日期：2018-01-01 00:00:00

abstract：:At our hospital, 47 out of 184 consecutive splenectomies performed over 7 recent years were carried out on patients afflicted with various hematologic diseases. The results of these 47 splenectomies were the subject of a careful retrospective analysis. The majority of the splenectomies (81%) were therapeutic. Cytopeni...

journal_title：Acta haematologica

authors： Dotevall A,Kutti J,Wadenvik H,Westin J,Angerås U,Darle N

更新日期：1987-01-01 00:00:00

abstract：:Essential thrombocythemia (ET), one of the chronic myeloproliferative disorders, is a clonal disorder of multipotent stem cells. Although most patients with ET have a prolonged benign course, a minority of patients may develop a blastic crisis similar to chronic myelogenous leukemia (CML). A case of ET terminating in ...

journal_title：Acta haematologica

authors： Shibata K,Shimamoto Y,Suga K,Sano M,Matsuzaki M,Yamaguchi M

更新日期：1994-01-01 00:00:00

abstract：INTRODUCTION:Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) down-regulation by preferentially expressed antigen of melanoma (PRAME) is a general phenomenon in different types of solid tumours, but research on the correlation between PRAME and TRAIL gene expression in leukaemia patients is rare. METHO...

journal_title：Acta haematologica

authors： Zhang W,Chi K,Zhang Y,Ma B,Shi J,Chen Y,Lei P,Li Y,Sun K

更新日期：2013-01-01 00:00:00

abstract：:Two human stromal cell lines were established previously from bone marrow-derived primary long-term cultures by immortalization using the SV40 large T antigen and cellular cloning. After irradiation, the fibroblast-like cell lines L87/4 and L88/5 support hematopoietic differentiation of allogeneic cord blood cells in ...

journal_title：Acta haematologica

authors： Thalmeier K,Meissner P,Moosmann S,Sagebiel S,Wiest I,Huss R

更新日期：2001-01-01 00:00:00

abstract：:The transcription factors GATA-1 and GATA-2 play key roles in gene regulation during erythropoiesis. Gene ablation studies in mouse revealed that GATA-2 is crucial for the maintenance and proliferation of immature hematopoietic progenitors, whereas GATA-1 is essential for the survival of erythroid progenitors as well ...

journal_title：Acta haematologica

authors： Ohneda K,Yamamoto M

更新日期：2002-01-01 00:00:00

abstract：:Glucocorticosteroid hormones have been reported either to stimulate or to inhibit human erythropoiesis. We have studied the in vitro effect of hydrocortisone, 10(-6) mol/l, on human BFU-E when stimulated by preconstituted burst-promoting activity (BPA) in a medium conditioned by T lymphocytes. Hydrocortisone was found...

journal_title：Acta haematologica

authors： Morra L,Ponassi A,Moccia F,Mela GS,Ponassi I,Bessone G

更新日期：1989-01-01 00:00:00

abstract：:The cutaneous inflammatory response in patients with Hodgkin's and non-Hodgkin's lymphomas was investigated by light and scanning electron microscopy and compared with that of healthy subjects at 24 and 48 h. Both groups of patients showed a reduction in overall cellularity and statistically significant differences in...

journal_title：Acta haematologica

authors： Sokol RJ,Durrant TE,Hudson G

更新日期：1980-01-01 00:00:00

abstract：:A 74-year-old woman was treated by lithium carbonate 3 x 300 mg per day for drug-induced aplastic anemia. After 8 days, she suddenly developed severe impairment of consciousness with myoclonias and hypertonia which persisted during 10 days despite lithium withdrawal and sodium chloride infusion. Slight disorders of wa...

journal_title：Acta haematologica

authors： Efira A,van Laethem Y,Ectors M,Unger J

更新日期：1980-01-01 00:00:00

abstract：:A modified cytochemical method was developed for demonstrating magnesium-activated adenosine triphosphatase in haemic cells. The enzyme was shown in a variety of normal and leukaemic, unfixed cells. The high sensitivity of this enzyme to all fixatives tried in this study hampered further exploration and characterizati...

journal_title：Acta haematologica

authors： Khalaf MR,Hayhoe FG

更新日期：1987-01-01 00:00:00

abstract：:Allogeneic stem cell transplantation (SCT) is the treatment of choice for selected patients with chronic myeloid leukemia (CML). However, it is associated with a high risk of treatment-related mortality (TRM) and morbidity. To assist in decision making about transplantation, a simple scoring system to assess the risk ...

journal_title：Acta haematologica

authors： Qazilbash MH,Devetten MP,Abraham J,Lynch JP,Beall CL,Weisenborn R,Bunner P,Ericson SG

更新日期：2003-01-01 00:00:00

abstract：:The detection of cellular antigens in bone marrow sections depends on the method of embedding, the nature of antigen and antibody, antigen retrieval techniques and the sensitivity of the immunohistochemical method. This study evaluated a fluorescyl-tyramide-enhanced immunostaining method on methyl-methacrylate-embedde...

journal_title：Acta haematologica

authors： Gaiser T,Bernhards J

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Not all patients with diffuse large B-cell lymphoma (DLBCL) are candidates for aggressive regimens. (90)Y ibritumomab tiuxetan ((90)Y-IT), an anti-CD20 radionuclide-conjugated antibody, has demonstrated clinical efficacy in DLBCL with a favorable toxicity profile. METHODS:This phase II trial investigated th...

journal_title：Acta haematologica

authors： Arnason JE,Luptakova K,Rosenblatt J,Tzachanis D,Avigan D,Zwicker JI,Levine J,Kim M,Parker JA,Grant B,Joyce RM

更新日期：2015-01-01 00:00:00