Abstract:
:In order to study the abnormal differentiation and proliferation of precursor T cells in homosexual men, a study was made of T-cell colony formation in 15 healthy homosexual men without anti-human immunodeficiency virus (HIV) antibody. The colony forming method used was the one-step monolayer technique using phytohemagglutinin as an inducer. Our results revealed that colony formation was extremely reduced and 3 cases showed no colony growth. However, with the addition of recombinant interleukin 2 to the culture system, the number of colonies increased up to the same level as in heterosexual controls. In addition, the analysis of CD3+, 4+, and 8+ cells of colony component cells revealed a decrease in CD3+ and 4+ cells. However, with the addition of recombinant interleukin 2, the numbers of CD3+ cells distinctly increased. The above results suggest that a disorder in the differentiation and proliferation of precursor T cells in homosexual men might be one of the causes of immunodeficiency.
journal_name
Acta Haematoljournal_title
Acta haematologicaauthors
Wakabayashi Y,Sugimoto M,Ishiyama T,Hashimoto M,Horie S,Hirose Sdoi
10.1159/000205374subject
Has Abstractpub_date
1989-01-01 00:00:00pages
187-92issue
4eissn
0001-5792issn
1421-9662journal_volume
82pub_type
杂志文章abstract::A rare case of acute promyelcytic leukemia (APL) is reported in a 7-year-old boy. The patient displayed the typical features of APL including impaction of the marrow with promyelocytes, marked elevation of the serum vitamin B12 and transcobalamin I levels and a hemorrhagic diathesis. The bleeding diathesis in the case...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207589
更新日期:1979-01-01 00:00:00
abstract::We evaluated an enzyme-linked immunosorbent assay (ELISA) for embryonic zeta-globin chains as a routine screening test for (--(SEA)) alpha-thalassemia deletion (SEA deletion). A total of 174 consecutive patient samples with a request for Hb analysis were recruited. The ELISA method was evaluated against a polymerase c...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000063060
更新日期:2002-01-01 00:00:00
abstract::Fetal liver transplantation was attempted in 7 patients with aplastic anemia. 4 of these patients showed a partial response as evidenced by decrease in blood transfusion requirements and increase in the peripheral blood counts and hematopoietic cells in the bone marrow. Bone marrow culture studies revealed evidence of...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207558
更新日期:1979-01-01 00:00:00
abstract::Deficiency in glucose-6-phosphate dehydrogenase (G6PD) is the most common enzymopathy, and more than 125 different mutations causing G6PD deficiency have been identified. Chronic haemolytic anaemia (CHA) associated with G6PD deficiency is rare, but there is a cluster of mutations causing CHA between amino acids 361-42...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000064749
更新日期:2002-01-01 00:00:00
abstract::96 consecutive acute myelogenous leukemia (AML) patients were analyzed retrospectively with regard to the regimen used for remission induction. 35 patients received daunorubicin for 3 days, cytosine arabinoside and 6-thioguanine for 7 days. 61 were treated with the same regimen but 6-thioguanine was replaced by etopos...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205173
更新日期:1990-01-01 00:00:00
abstract::A case of lymphoma presenting with features shared by hairy cell leukemia (HCL) and its variant, intermediate lymphocytic lymphoma (ILL) and monocytoid B-cell lymphoma (MBCL) is described. Clinical presentation and the morphological findings observed in peripheral blood and in bone marrow biopsy suggested an HCL; howe...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204496
更新日期:1993-01-01 00:00:00
abstract::The transcription factors GATA-1 and GATA-2 play key roles in gene regulation during erythropoiesis. Gene ablation studies in mouse revealed that GATA-2 is crucial for the maintenance and proliferation of immature hematopoietic progenitors, whereas GATA-1 is essential for the survival of erythroid progenitors as well ...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000065660
更新日期:2002-01-01 00:00:00
abstract::A case of acquired haemophilia A presenting with extensive spontaneous bruising and anaemia is reported. The anaemia was due to myelodysplastic syndrome (FAB: refractory anaemia with ringed sideroblasts). A factor-VII:C-specific inhibitor was also found. Prednisone and pyridoxine were given, and the inhibitor became u...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204894
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Thalassemia is a group of hereditary hemoglobinopathies caused by decreased or absent synthesis of α and/or β globin chains. Studies have shown that hypercoagulability and thrombosis are common clinical symptoms in β-thalassemia, especially β-thalassemia intermedia, but little is known about in α-thalassemia...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000486157
更新日期:2018-01-01 00:00:00
abstract::Recent molecular biological investigations have shown that genetic information on the short arm of chromosome 17 is frequently deleted or inactivated in acute myeloid leukaemias and a number of solid tumours. In earlier studies we have found clonal occurrence of a 17p deletion (17p-) in patients with refractory anaemi...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205033
更新日期:1990-01-01 00:00:00
abstract::Cancer patients not undergoing treatment and without a history of venous thrombosis do not, as a general rule, require prophylaxis. However, venous thromboembolism is of sufficient magnitude in patients undergoing treatment for cancer for thromboprophylaxis to be routinely employed. The mainstay of primary prevention ...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000046592
更新日期:2001-01-01 00:00:00
abstract::The effect of total-body cold exposure on plasma concentrations of von Willebrand factor (vWF), endothelin-1 (ET) and thrombomodulin (TM), all of which are considered to be generated from the endothelium, was studied in systemic lupus erythematosus (SLE) patients with and without Raynaud's phenomenon. The plasma level...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204684
更新日期:1992-01-01 00:00:00
abstract::We have studied the amount and intracellular distribution of erythroblastic alkaline and acid phosphatase, nonspecific esterase, and N-acetyl-beta-glucosaminidase in 50 patients with acquired dyserythropoiesis. 19 morphologically normal bone marrow smears served as controls. Alkaline phosphatase was found in all contr...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206406
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND/AIMS:The aim of this work was to investigate the efficacy and predictive factors of CLAG treatment in refractory or relapsed (R/R) acute myeloid leukemia (AML) patients. METHODS:Sixty-seven R/R AML patients were enrolled in this prospective cohort study and treated by a CLAG regimen: 5 mg/m2/day cladribine ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000493250
更新日期:2019-01-01 00:00:00
abstract::We present the case of a woman undergoing treatment with acenocoumarol for deep vein thrombosis, who maintained an international normalized ratio (INR) of between 2.5 and 4 for 2 months. Seven days after the introduction of amoxycillin (500 mg/8 h) for a probable respiratory infection, the patient developed spontaneou...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204457
更新日期:1993-01-01 00:00:00
abstract::Hypercalcemia is a significant feature of patients with active multiple myeloma (MM) with extensive bone disease. Among the causes of non-neoplastic hypercalcemia, primary hyperparathyroidism (PHPT) is one of the most common, leading to osteoporosis and bone fractures. Interestingly, some preclinical data indicate tha...
journal_title:Acta haematologica
pub_type:
doi:10.1159/000509768
更新日期:2020-09-09 00:00:00
abstract::Treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute leukemia (Ph+ ALL) has been revolutionized with the advent of tyrosine kinase inhibitors (TKIs). Most patients with CML achieve long-term survival similar to individuals without CML due to treatment with TKIs not only in frontline b...
journal_title:Acta haematologica
pub_type: 共识发展会议,杂志文章,评审
doi:10.1159/000501927
更新日期:2020-01-01 00:00:00
abstract::A new variant of red cell glucose-6-phosphate dehydrogenase (G6PD) has been found in a Caucasian man with congenital non-spherocytic haemolytic anaemia. This variant has reduced activity, increased thermolability, increased Michaelis constants for glucose-6-phosphate and NADP, slightly increased electrophoretic mobili...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207869
更新日期:1977-01-01 00:00:00
abstract::Serum folate levels and unsaturated folate-binding capacity (UFBC) in a mixed population of outpatients and inpatients were analyzed with respect to race, sex, and age. The results supported the relatively high prevalence of subnormal serum folates in patient populations, did not find lower serum folates in the elderl...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206909
更新日期:1983-01-01 00:00:00
abstract::The BCR-ABL fusion gene represents the hallmark of chronic myelogenous leukemia (CML) and is derived from a translocation between chromosome 9 and 22. The majority of CML patients have a breakpoint in the major BCR region of the BCR gene giving rise to e13a2 or e14a2 BCR-ABL transcripts. Occasionally, other BCR breakp...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000230037
更新日期:2009-01-01 00:00:00
abstract::We examined the in vivo effect of granulocyte colony-stimulating factor (G-CSF) on the surface expression of putative counterligands for endothelial selectins on neutrophils in healthy volunteers. G-CSF (50 microg/m2/day) was administered subcutaneously to 5 healthy volunteers for 4 days. The expression of surface ant...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000040901
更新日期:1998-01-01 00:00:00
abstract::One of the major determinants of erythrocyte survival is membrane deformability, and an important intrinsic parameter of membrane deformability is the shear elastic modulus (mu) with higher mu values corresponding to increased membrane rigidity. Using a micropipette technique, we determined the shear elastic modulus o...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204753
更新日期:1992-01-01 00:00:00
abstract::The establishment of mouse and human monoclonal anti-DNA antibodies is described. Common idiotypes were identified on these antibodies employing monoclonal (mouse) and polyclonal anti-idiotypic antibodies. The significance of the presence and titer of the common idiotypes as clinical activity marker was examined in pa...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206029
更新日期:1986-01-01 00:00:00
abstract::A 74-year-old woman was treated by lithium carbonate 3 x 300 mg per day for drug-induced aplastic anemia. After 8 days, she suddenly developed severe impairment of consciousness with myoclonias and hypertonia which persisted during 10 days despite lithium withdrawal and sodium chloride infusion. Slight disorders of wa...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207314
更新日期:1980-01-01 00:00:00
abstract::An increased bone marrow (BM) apoptosis is one of the mechanisms responsible for the ineffective hematopoiesis of myelodysplastic syndromes (MDS). It is controversial whether the excessive apoptosis in myelodysplasia predominantly involves the subset of progenitor cells or of maturing cells. We investigated the degree...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000067275
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Our aim is to determine comorbidities associated with pulmonary hypertension (PHT) in clinically stable sickle-cell disease (SCD) patients and to evaluate left ventricular (LV) and right ventricular (RV) function in those patients. METHODS:Echocardiography was performed in 87 SCD patients that were divided ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000102588
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:Reticulated platelets circulating in the blood reflect megakaryopoietic activity and platelet turnover and can be automatically and low-invasively measured as the immature platelet fraction (IPF) using a Sysmex XN hematocytometer. The present study retrospectively investigated whether or not the IPF can pred...
journal_title:Acta haematologica
pub_type: 新闻
doi:10.1159/000510460
更新日期:2020-09-17 00:00:00
abstract::We describe a B cell chronic lymphocytic leukemia/lymphoma (B-CLL) patient with an adrenocortical adenoma. He was treated initially with oral cyclophosphamide and prednisolone for 2 months, followed by low-dose prednisolone for an additional 2 years, which resulted in the prompt disappearance of CLL cells. After a per...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000203692
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND/AIMS:Autophagy is crucial for the survival and function of plasma cells including protection from toxic misfolded immunoglobulin and proper energy metabolism. Multiple myeloma (MM) is an indolent but eventually fatal neoplasm of plasma cells. Autophagy may play a critical role in the survival of MM cells and...
journal_title:Acta haematologica
pub_type: 临床试验,杂志文章
doi:10.1159/000368848
更新日期:2015-01-01 00:00:00
abstract::Transient regression in the lymphocyte count of a patient with B-cell chronic lymphocytic leukemia (B-CLL) after viral infection is reported. A similar event occurred under natural interferon-alpha (IFN-alpha) treatment. It was confirmed that the event was not caused by a direct cytotoxic effect of IFN-alpha by analyz...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204091
更新日期:1995-01-01 00:00:00