Transient regression in lymphocyte count in B-cell chronic lymphocytic leukemia after viral infection.

Abstract:

:Transient regression in the lymphocyte count of a patient with B-cell chronic lymphocytic leukemia (B-CLL) after viral infection is reported. A similar event occurred under natural interferon-alpha (IFN-alpha) treatment. It was confirmed that the event was not caused by a direct cytotoxic effect of IFN-alpha by analyzing the DNA fragmentation to estimate apoptotic and necrotic cell death before and after the administration of IFN-alpha. The study also suggested that the event was not caused by a cytostatic effect of IFN-alpha.

journal_name

Acta Haematol

journal_title

Acta haematologica

authors

Shirono K,Ikebe M,Inada T,Tsuda H

doi

10.1159/000204091

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

46-9

issue

1

eissn

0001-5792

issn

1421-9662

journal_volume

93

pub_type

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