Abstract:
BACKGROUND:It is a common belief among women that iron compounds have unpleasant gastrointestinal side effects. OBJECTIVE:To assess the gastrointestinal side effects of iron prophylaxis in pregnancy. METHODS:A randomized, double-blind study comprising 404 healthy pregnant women allocated to four groups taking ferrous iron supplement (as fumarate) in doses of 20 (n = 99), 40 (n = 100), 60 (n = 102) and 80 mg (n = 103) daily from 18 weeks of gestation to delivery. Iron supplement was predominantly taken at bedtime. Gastrointestinal symptoms (nausea, vomiting, epigastric pain, eructation, pyrosis, meteorism, borborygmi, colic pain, flatulence, constipation, thin feces, diarrhea), black feces, and use of laxatives were recorded by interview at 18, 32 and 39 weeks of gestation. RESULTS:The frequencies of gastrointestinal symptoms were not significantly different in the four iron supplement groups either at inclusion or at 32 and 39 weeks of gestation and thus not related to the iron dose. CONCLUSION:This study shows that a supplement of 20-80 mg ferrous iron (as fumarate), taken between meals, has no clinically significant gastrointestinal side effects. The implementation of iron prophylaxis to pregnant women should not be compromised by undue concern of non-existing side effects.
journal_name
Acta Haematoljournal_title
Acta haematologicaauthors
Milman N,Byg KE,Bergholt T,Eriksen Ldoi
10.1159/000089466subject
Has Abstractpub_date
2006-01-01 00:00:00pages
53-7issue
1-2eissn
0001-5792issn
1421-9662pii
89466journal_volume
115pub_type
杂志文章,随机对照试验abstract::An ultrastructural study of the aspirated bone marrow of a patient with congenital dyserythropoietic anemia type I is presented. Both in transmission electron microscopy (TEM) and in scanning electron microscopy (SEM) ultrastructural abnormalities of the bone marrow erythroid precursors were seen. These abnormalities ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206735
更新日期:1983-01-01 00:00:00
abstract::The concentration of plasma vitamin B12 bound to transcobalamin II was measured by two methods: QUSO and Heparin Sepharose (HS). The new HS procedure provided a specific, direct measurement of vitamin B12 bound to both R binder and transcobalamin II in plasma. ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204522
更新日期:1993-01-01 00:00:00
abstract::The detection of cellular antigens in bone marrow sections depends on the method of embedding, the nature of antigen and antibody, antigen retrieval techniques and the sensitivity of the immunohistochemical method. This study evaluated a fluorescyl-tyramide-enhanced immunostaining method on methyl-methacrylate-embedde...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000097458
更新日期:2007-01-01 00:00:00
abstract::A family with hereditary ovalocytosis (HO) is described. The probands, 2 brothers, had splenic rupture after modest trauma as preenting symptoms. 7 members of the family had HO. The sister of the pobands had a moderately enlarged spleen. The other members proved normal on routine clinical examination. ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207420
更新日期:1980-01-01 00:00:00
abstract::We have used the gel retardation assay to investigate the binding of nuclear proteins to the duplicated CACCC boxes in the beta-globin gene promoter region. The effect of beta-thalassemia mutations affecting both of these consensus sequences (the -88 C-->T and -101 C-->T mutations) were studied by using appropriate mu...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204237
更新日期:1994-01-01 00:00:00
abstract::Basic fibroblast growth factor (b-FGF) mediates a variety of biological responses such as angiogenesis and hematopoiesis. We examined the effect of b-FGF on human neutrophil functions in vitro. The surface expression of effector cell molecules on neutrophils was determined by flow cytometry and monoclonal antibodies. ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000041024
更新日期:2000-01-01 00:00:00
abstract::A study of E-rosette ultrathin sections has been undertaken in an attempt to analyze changes induced during the T-lymphocyte-sheep red blood cell interaction on the rosetted lymphocyte surface architecture. The formation of nonimmune rosettes implies different types of attachment between lymphocytes and sheep red bloo...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207570
更新日期:1979-01-01 00:00:00
abstract::A 64-year-old man with multiple sclerosis developed a circulating anticoagulant. Three immunoglobulin fractions (I = IgG; II =IgG+IgA; III = IgM) were separated from patient serum by 33-percent ammonium sulfate precipitation and DEAE-52 cellulose column chromatography. Fractions I (IgG) and II (IgG+IgA) had factor VII...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207993
更新日期:1976-01-01 00:00:00
abstract::We have demonstrated that hemopoietic organ fibroblastoid cells can produce colony-stimulating activity (CSA) in vitro. Skin fibroblasts also produced CSA. The colonies which formed were restricted to the granulocyte/macrophage differentiation pathways. A linear relationship was obtained for granulocyte/macrophage col...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206924
更新日期:1983-01-01 00:00:00
abstract::Using enzyme-linked immunosorbent assay (ELISA) and confirmatory immunoprecipitation tests, sera from 640 Nigerians from Lagos and Cross River States were examined for antibodies against HIV. These comprised 570 blood donors and their family members, 56 patients with various haematological conditions and 14 patients w...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205728
更新日期:1988-01-01 00:00:00
abstract::The case history of a 71-year-old woman with three episodes of a microangiopathic hemolytic anemia over a 22-year span is detailed. During the last episode a possible response of her thrombotic thrombocytopenic purpura (TTP)-like syndrome to the administration of intravenous immunoglobulin is documented. In retrospect...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000205377
更新日期:1989-01-01 00:00:00
abstract::We have been studying hematopoietic effects by the tachykinins, which like many other neuropeptides can be expressed in neural and nonneural tissues. Substance P (SP) and neurokinin-A (NK-A), members of the tachykinins are immune and hematopoietic modulators. SP and NK-A are derived from the preprotachykinin-I gene (P...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000203593
更新日期:1997-01-01 00:00:00
abstract::Extensive bone marrow necrosis and symptomatic hypercalcemia have been described independently as rare complications of chronic myeloid leukemia. Here we report a 66-year-old man who developed B cell blastic transformation 10 years after diagnosis of CML in the chronic phase. Extensive bone marrow necrosis and symptom...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000106100
更新日期:2007-01-01 00:00:00
abstract::34 patients with myocardial infarction were studied with daily measurements of beta-thromboglobulin (BTG) and 125I fibrinogen scanning in order to detect deep-venous thrombosis (DVT). Serial levels of BTG were unhelpful in the early detection of this condition, which occurred in 7 of the patients studied. 5 of the pat...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207238
更新日期:1980-01-01 00:00:00
abstract::The effects of lithium on the microtubular and microfilament systems of neutrophil granulocytes is described. The phagocytic capacity of human neutrophils was reduced or inhibited by using vinblastine or cytochalasin B. Lithium at concentrations ranging from 0.5 to 2.0 mEq/l proved to be capable of antagonising the ac...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206173
更新日期:1985-01-01 00:00:00
abstract::Richter syndrome (RS) describes the development of high-grade non-Hodgkin's lymphoma (NHL) from low-grade NHL. RS isolated to the brain is very rare and has a poor prognosis. We describe the cases of high-grade large B-cell diffuse NHL in a 56-year-old male with chronic lymphocytic leukemia and in a 71-year-old female...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000334068
更新日期:2012-01-01 00:00:00
abstract::To evaluate the effect of granulocyte/colony-stimulating factor (G-CSF) on the onset of the adult respiratory distress syndrome (ARDS), we investigated whether the incidence of ARDS due to pulmonary infection differed between the G-CSF group which received chemotherapy with G-CSF and historical controls without G-CSF....
journal_title:Acta haematologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000040937
更新日期:1999-01-01 00:00:00
abstract::With the widespread use of genetic diagnostic technologies, many novel mutations have been identified in hereditary spherocytosis (HS)-related genes, including SPTA1, SPTB, ANK1, SLC4A1, and EPB42. However, mutations in HS-related genes are dispersed and nonspecific in the diagnosis of some HS patients, indicating sig...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000486229
更新日期:2018-01-01 00:00:00
abstract::Iron overload due to regular transfusions of packed red cells can cause multiple organ damage. Iron chelation therapy (ICT) is important in patients with aplastic anemia (AA) who require blood transfusions as supportive management. With the introduction of the oral iron chelator deferasirox, ICT has become more widely...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000342772
更新日期:2013-01-01 00:00:00
abstract::Interferon-alpha has been used as standard therapy for patients with Philadelphia-positive chronic myeloid leukemia (CML) for more than 20 years. Recently randomized trials have shown a superiority of the tyrosine kinase inhibitor imatinib in respect to its efficacy to induce complete hematological and cytogenetic rem...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000089476
更新日期:2006-01-01 00:00:00
abstract::We describe in this paper a female patient affected by chronic granulomatous disease with all the features of the classic X-linked form of the disease and presenting a mild form of the disease, the major clinical manifestation being a granulomatous cheilitis. The capability of the patient's phagocytes to undergo a res...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205028
更新日期:1990-01-01 00:00:00
abstract::Primary lymphoma of the female genital tract is very rare. We report the case of a 36-year-old woman who was referred to our hospital because of an indeterminate Pap smear test. The colposcopy showed a thickening of the posterior vaginal wall and various irregular ulcerated nodular lesions. Histological examination, i...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000337336
更新日期:2012-01-01 00:00:00
abstract::A case of multiple pyarthroses due to Staphylococcus aureus occurring in a severe classical hemophiliac is presented. Successful management depended on drainage of the infected joints and a prolonged course of antibiotics. Several criteria are suggested for recognition of hemophiliacs who might benefit from joint aspi...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206569
更新日期:1984-01-01 00:00:00
abstract::Agranulocytosis is a rare side effect of phenytoin treatment. We describe the case of an elderly man who developed agranulocytosis 2 weeks following initiation of phenytoin treatment, on no cytotoxic drugs or any other medications except decadron. The white blood cell count was 300/mm3 with absent granulocytes. The li...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204838
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Immunotherapy using recombinant human interleukin-2 (rIL-2) produces objective responses in a proportion of advanced cancer patients. While early investigators employed intravenous (i.v.) treatment regimens, recent clinical trials applied therapy schedules via subcutaneous (s.c.) injection, mostly in combina...
journal_title:Acta haematologica
pub_type: 临床试验,杂志文章
doi:10.1159/000204503
更新日期:1993-01-01 00:00:00
abstract::A patient with regional enteritis had received iron dextran for treatment of iron deficiency. Subsequently he developed a large (3.1 g/100 ml) IgG-K serum spike which had precipitin activity against dextran sulfate but not a variety of other antigens. There has been no evidence of multiple myeloma and the spike gradua...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207755
更新日期:1978-01-01 00:00:00
abstract::We have studied the amount and intracellular distribution of erythroblastic alkaline and acid phosphatase, nonspecific esterase, and N-acetyl-beta-glucosaminidase in 50 patients with acquired dyserythropoiesis. 19 morphologically normal bone marrow smears served as controls. Alkaline phosphatase was found in all contr...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206406
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Thalassemia is a group of hereditary hemoglobinopathies caused by decreased or absent synthesis of α and/or β globin chains. Studies have shown that hypercoagulability and thrombosis are common clinical symptoms in β-thalassemia, especially β-thalassemia intermedia, but little is known about in α-thalassemia...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000486157
更新日期:2018-01-01 00:00:00
abstract::High-dose gammaglobulin therapy for patients with idiopathic thrombocytopenic purpura (ITP), introduced by Imbach et al., was applied to 5 adults with chronic refractory ITP to investigate the mechanism of the increase in platelet counts. In 4 of the 5 cases, transient increase in platelet count was observed. Platelet...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206927
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:This study aimed to compare the curative effects of the combination therapy of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO, As₂O₃) with ATRA monotherapy on newly diagnosed acute promyelocytic leukemia (APL). METHODS:The studies were retrieved from PubMed, EMBASE, Cochrane Library, ChinaInfo and...
journal_title:Acta haematologica
pub_type: 杂志文章,meta分析
doi:10.1159/000369242
更新日期:2015-01-01 00:00:00