Abstract:
:Iron overload due to regular transfusions of packed red cells can cause multiple organ damage. Iron chelation therapy (ICT) is important in patients with aplastic anemia (AA) who require blood transfusions as supportive management. With the introduction of the oral iron chelator deferasirox, ICT has become more widely available and feasible. We studied 4 adult AA patients who had transfusion-induced iron overload and showed hematological improvement after ICT with oral deferasirox. Following deferasirox treatment, hemoglobin increased and serum ferritin levels decreased, and the patients subsequently became transfusion independent. Our experience raises the possibility of the potential benefit of ICT on hematopoiesis. Further long-term studies in larger patient cohorts are needed to clarify the effect of the restoration of hematopoiesis after iron chelation therapy.
journal_name
Acta Haematoljournal_title
Acta haematologicaauthors
Lee SE,Yahng SA,Cho BS,Eom KS,Kim YJ,Lee S,Min CK,Kim HJ,Cho SG,Kim DW,Min WS,Park CW,Lee JWdoi
10.1159/000342772subject
Has Abstractpub_date
2013-01-01 00:00:00pages
72-7issue
2eissn
0001-5792issn
1421-9662pii
000342772journal_volume
129pub_type
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更新日期:1995-01-01 00:00:00
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更新日期:1983-01-01 00:00:00
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