Abstract：
:While sickle cell disease (SCD) is generally mild in most Kuwaitis, because of their elevated fetal Hb levels, avascular necrosis of the femoral head (AVNFH) appears to be a common complication. It was recently documented in 26.7% of Kuwaiti children with SCD. There have, however, been no previous studies of adult patients. This is a 1-year study of consecutive, steady-state SCD patients seen in the hematology clinic of Mubarak Al-Kabeer Hospital. The patients' charts were reviewed for frequency of hospitalizations, any documented complications and steady-state complete blood count (CBC). MRI was performed using T1- and T2-weighted FATSAT sequences in coronal and axial planes with 4-mm-thick slices on a 1.5-tesla GE super-conducting magnet. Thirty-five patients were studied, consisting of 25 SS and 10 Sbeta(0)Thal patients aged between 17 and 44, with a mean age of 26.7 +/- 9.3 years. Seventeen (48.6%) had varying degrees of AVNFH; among the 70 hips examined, 29 (41.1%) were affected. Of the 17 patients affected, 11 (64.7%) were SS, while 6 (35.3%) were Sbeta(0)Thal. There were 14 (82.4%) males and 3 (17.6%) females (chi(2) = 8.6, p < 0.01). The mean age of those affected, 27.5 +/- 10.7 years, was not significantly higher than that of the unaffected (26.3 +/- 8.0 years). Eleven (64.7%) of those affected had a history of frequent vaso-occlusive crisis. No significant differences could be demonstrated in the mean CBC and Hb F values of the two groups; coexistent alpha-thal trait was not a factor in the SS group. Male gender was the only significant predisposing factor identified. While more patients with frequent vaso-occlusive crises were affected, the difference was not significant. AVNFH is, indeed, quite common among Kuwaiti SCD patients and there is a need for early institution of preventive and therapeutic protocols.
journal_name
Acta Haematoljournal_title
Acta haematologicaauthors
Marouf R,Gupta R,Haider MZ,Al-Wazzan H,Adekile ADdoi
10.1159/000072406subject
Has Abstractpub_date
2003-01-01 00:00:00pages
11-5issue
1eissn
0001-5792issn
1421-9662pii
72406journal_volume
110pub_type
杂志文章abstract：:In 83 children with acute lymphoblastic leukaemia (ALL) the immunological phenotype of the lymphoblasts was determined using E rosetting, monoclonal anti-T cell sera, surface immunoglobulin staining and common ALL antiserum. The data were compared with acid alpha-naphthyl acetate esterase (ANAE) and acid phosphatase (...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206835
更新日期：1983-01-01 00:00:00
abstract：:A 28-year-old woman with Bence-Jones multiple myeloma (MM) presented with several osteolytic lesions and a massive bone marrow infiltration with mature plasmocytes. After 6 cycles of chemotherapy with melphalan and prednisone, the patient, in apparent clinical remission, underwent allogeneic bone marrow transplantatio...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000205969
更新日期：1987-01-01 00:00:00
abstract：:To characterize intracellular signaling in peripheral blood (PB) cells of acute myeloid leukemia (AML) patients undergoing pretransplant conditioning with CXCR4 inhibitor plerixafor, granulocyte colony-stimulating factor (G-CSF), and busulfan plus fludarabine (Bu+Flu) chemotherapy, we profiled 153 proteins in 33 funct...
journal_title：Acta haematologica
pub_type： 临床试验,杂志文章
doi：10.1159/000495456
更新日期：2019-01-01 00:00:00
abstract：:We present a case with the clinical and pathological impression of Ph1-positive chronic myelogenous leukemia in extramedullary blast crisis involving lymph nodes as demonstrated by morphological and cytogenetic studies. The hyperploid cell lines that were present in the lymph node were not present in the bone marrow. ...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206166
更新日期：1985-01-01 00:00:00
abstract：:It has been found possible to test ferritin concentrations in the reticulum and hemopoietic cells from human bone marrow by an immunoradiometric assay. Ferritin concentration in healthy test persons amounts to 0.92 +/- 0.38 ng/microgram protein in the reticulum and 0.084 +/- 0.031 ng/microgram protein in hemopoietic c...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000207030
更新日期：1982-01-01 00:00:00
abstract：:Fourteen patients with hematologic neoplasia (11 acute myeloid leukemias, 2 non-Hodgkin's lymphomas and 1 blast crisis of chronic myeloid leukemia) who underwent high-dose cytosine arabinoside (HIDARAC) therapy with or without sequential asparaginase (ASNase) were investigated in order to evaluate liver toxicity and a...
journal_title：Acta haematologica
pub_type： 临床试验,杂志文章
doi：10.1159/000206094
更新日期：1986-01-01 00:00:00
abstract：:A patient developed a drug rash and neutropenia while receiving tobramycin, ticarcillin and flucloxacillin intravenously for osteomyelitis. Incorporation of these antibiotics into in vitro cultures of bone marrow granulocyte macrophage precursors (CFU-C) showed no inhibition of the patient's marrow or normal marrow by...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206794
更新日期：1983-01-01 00:00:00
abstract：:Downregulation of apoptosis has been proposed as a mechanism of clonal expansion in low-grade B cell neoplasms. We have previously described an unusual case of CD5+ B cell lymphoma characterized by cycles of leukemic phase alternating with spontaneous remission. In the present study, we examined the involvement of apo...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000041046
更新日期：2000-01-01 00:00:00
abstract：:Red cell glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-chromosomal-linked abnormality often associated with hemolytic anemia. The G6PD variants obtained from 2 unrelated males, one associated with enzyme deficiency and history of hemolytic jaundice, and the other associated with enzyme deficiency but no ...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206354
更新日期：1984-01-01 00:00:00
abstract：:A 12-year-old male of Chinese ancestry had life-long hemolytic anemia attributed to alpha-thalassemia. Restriction endonuclease mapping of his DNA revealed that in reality, he had three alpha-globin loci, but he was homozygous for pyruvate kinase deficiency. The new pyruvate kinase variant carried by this patient was ...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206830
更新日期：1983-01-01 00:00:00
abstract：BACKGROUND:Not all patients with diffuse large B-cell lymphoma (DLBCL) are candidates for aggressive regimens. (90)Y ibritumomab tiuxetan ((90)Y-IT), an anti-CD20 radionuclide-conjugated antibody, has demonstrated clinical efficacy in DLBCL with a favorable toxicity profile. METHODS:This phase II trial investigated th...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000368291
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Thalassemia is a group of hereditary hemoglobinopathies caused by decreased or absent synthesis of α and/or β globin chains. Studies have shown that hypercoagulability and thrombosis are common clinical symptoms in β-thalassemia, especially β-thalassemia intermedia, but little is known about in α-thalassemia...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000486157
更新日期：2018-01-01 00:00:00
abstract：:A 29-year-old man with acute myelomonocytic leukemia had an initial leukocyte count of 192 X 10(9) cells/l and 84% blasts. During the initial treatment with hydroxyurea, 1 g/m2 orally tid, he developed pulmonary leukostasis which responded rapidly to whole-lung radiation with 1.5 Gy in one fraction. Pulmonary leukosta...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000205987
更新日期：1987-01-01 00:00:00
abstract：:Serological and biochemical studies were performed on M components isolated from 3 patients with transitional cell carcinoma of the urinary bladder (TCC). All were IgG1(K) proteins. 2 of the 3 belonged to the VKI subgroup, and these 2 also possessed cross-reactive idiotypic determinants. These findings are consistent ...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206983
更新日期：1982-01-01 00:00:00
abstract：:A mild anemia (hemoglobin 9 g/dl) was found in a patient from Seville (Spain) with marked morphological abnormalities in the peripheral blood smear. The red cell osmotic fragility showed a mild resistance curve with a mean cell fragility (MCF) of 0.375% NaCl (normal = 0.450). Chemical Chemical and thermal instability ...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206274
更新日期：1985-01-01 00:00:00
abstract：:We review the problem of lymphoma classification in the light of the Revised European-American Lymphoma (REAL) scheme, recently proposed by the International Lymphoma Study Group (ILSG). The REAL classification is a list of clinicopathologic entities, all well known from the literature, upon which the ILSG members agr...
journal_title：Acta haematologica
pub_type： 杂志文章,评审
doi：10.1159/000203875
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:In 2003, oral fludarabine was introduced in the USA for the treatment of patients with hematologic malignancies as an alternative to its intravenous (i.v.) formulation; in 2008, it was introduced in México while the i.v. formulation was withdrawn. Accordingly, i.v. fludarabine had to be replaced by oral flud...
journal_title：Acta haematologica
pub_type： 临床试验,杂志文章
doi：10.1159/000357108
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To investigate a family with factor VII (FVII) deficiency from Argentina. PATIENTS AND METHODS:The proposita is a 14-year-old girl who presented with a mild to moderate bleeding tendency. Menorrhagia is controlled with periodical administration of small doses of recombinant FVII concentrate. The mother of th...
journal_title：Acta haematologica
pub_type：
doi：10.1159/000507071
更新日期：2021-01-01 00:00:00
abstract：:Scanning electron microscopy has shown a typical cell surface morphology in hairy cell leukemia. Scanning immunoelectron microscope techniques, utilizing monoclonal antibodies and colloidal gold particles, have recently become available. Eight patients with hairy cell leukemia have been studied with a panel of monoclo...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206218
更新日期：1985-01-01 00:00:00
abstract：:The level of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the cerebrospinal fluid from 14 infants and children with meningitis and 6 patients who suffered other diseases besides meningitis was measured by our sensitive enzyme linked immunosorbent assay for GM-CSF. The minimal detection level of GM-CSF ...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000204796
更新日期：1991-01-01 00:00:00
abstract：:A 59-year-old man with beta-thalassaemia major is unusually well. He has no beta-chains in his haemoglobin but is heterozygous for the genes responsible for alphaA and for alphaG Philadelphia. In addition he is also heterozygous for the genes responsible for gammaF and a new gamma-chain, gamma75(E19) Ile-Thr, named ga...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000208204
更新日期：1975-01-01 00:00:00
abstract：OBJECTIVES:Reticulated platelets circulating in the blood reflect megakaryopoietic activity and platelet turnover and can be automatically and low-invasively measured as the immature platelet fraction (IPF) using a Sysmex XN hematocytometer. The present study retrospectively investigated whether or not the IPF can pred...
journal_title：Acta haematologica
pub_type： 新闻
doi：10.1159/000510460
更新日期：2020-09-17 00:00:00
abstract：:With the widespread use of genetic diagnostic technologies, many novel mutations have been identified in hereditary spherocytosis (HS)-related genes, including SPTA1, SPTB, ANK1, SLC4A1, and EPB42. However, mutations in HS-related genes are dispersed and nonspecific in the diagnosis of some HS patients, indicating sig...
journal_title：Acta haematologica
pub_type： 杂志文章,评审
doi：10.1159/000486229
更新日期：2018-01-01 00:00:00
abstract：:The first thrombocytopenia cases related to the human immunodeficiency virus (HIV) were described even before its isolation in 1983. Subsequently, multiple mechanisms have been proposed to elucidate the etiology of thrombocytopenia. In addition to other types of cytopenia affecting patients with HIV, thrombocytopenia ...
journal_title：Acta haematologica
pub_type： 杂志文章,评审
doi：10.1159/000313782
更新日期：2010-01-01 00:00:00
abstract：:The distribution of thymus-dependent (T cells) and bone marrow-derived lymphocytes (B cells) was studied in 74 patients with Hodgkin's disease and 33 normal controls. A T cell deficit was found in untreated patients as well as in long-term survivors in remission. Therapy slightly enhanced the T cell depletion in Hodgk...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000207911
更新日期：1976-01-01 00:00:00
abstract：:The goal of the study was to investigate changes in expression of selected growth factors tentatively involved in regeneration of haematopoietic tissues (bone marrow and spleen) following cyclophosphamide (CY) damage in the mouse. The bone marrow (BM) and spleen were examined separately, since the regenerating pattern...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000068490
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:The incidence of venous thromboembolism (VTE) in haematological malignancies varies according to the type and grade of the disease and clinical variables, and there is a need to develop a tool to predict the occurrence of VTE in cancer patients at diagnosis to tailor prophylactic anticoagulation use during t...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000496914
更新日期：2019-01-01 00:00:00
abstract：:Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a rare lymphoproliferative disorder characterized by diffuse lymphadenopathy, fever, hepatosplenomegaly, hemolytic anemia, and polyclonal hypergammaglobulinemia. Morphologically, the involved lymph nodes demonstrate complete effacement of the normal arch...
journal_title：Acta haematologica
pub_type： 杂志文章,评审
doi：10.1159/000040811
更新日期：1998-01-01 00:00:00
abstract：:A diester lipase activity is described in human red blood cells (RBC). Diester lipase activity acts as a membrane-bound enzyme and is assayed using intact RBC as the enzyme source. An emulsion of di-[3H]-oleoylglycerol (0.6 mM) serves as the substrate. The optimum pH for the reaction is 7.8 at 37 degrees C. Lipolytic ...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206770
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:The aim of this investigation was to study the effect of vitamin E treatment in oxidative stress of red and white cells of beta-thalassaemia intermedia patients. METHODS:Nine patients undergoing occasional transfusions (5 females/4 males), median age 39 years (range 15-74), were recruited for oral daily admi...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000201988
更新日期：2008-01-01 00:00:00
