Abstract:
BACKGROUND:The incidence of venous thromboembolism (VTE) in haematological malignancies varies according to the type and grade of the disease and clinical variables, and there is a need to develop a tool to predict the occurrence of VTE in cancer patients at diagnosis to tailor prophylactic anticoagulation use during treatment. OBJECTIVE:To study the incidence of VTE in haematological malignancies and clarify whether vascular and inflammatory biomarkers could be used as predictors of VTE in those patients. METHODS:This was a prospective observational cohort study. Hypercoagulability and inflammatory biomarkers were assayed in a group of 171 patients with haematological malignancies at diagnosis. These markers included (1) coagulation and fibrinolysis activation markers (D-dimer, fibrinogen, antithrombin, plasminogen activator inhibitor 1), (2) endothelial and platelet activation markers (von Willebrand factor and soluble P-selectin), and (3) inflammatory markers (tumour necrosis factor αand interleukin 6). The end point was mortality or symptomatic VTE. RESULTS/CONCLUSION:The incidence of symptomatic VTE was 7%. None of the tested biomarkers showed statistical significance as predictors for the occurrence of VTE in haematological malignancies. However, there were statistically significant associations between the occurrence of VTE and central venous access device insertion, the prothrombin time, and the erythrocyte sedimentation rate. An ESR above 106.5 mm/h is associated with increased VTE occurrence.
journal_name
Acta Haematoljournal_title
Acta haematologicaauthors
Elmoamly S,Mattar M,Yacoub MF,Afif Adoi
10.1159/000496914subject
Has Abstractpub_date
2019-01-01 00:00:00pages
245-253issue
4eissn
0001-5792issn
1421-9662pii
000496914journal_volume
141pub_type
杂志文章abstract::We have demonstrated that hemopoietic organ fibroblastoid cells can produce colony-stimulating activity (CSA) in vitro. Skin fibroblasts also produced CSA. The colonies which formed were restricted to the granulocyte/macrophage differentiation pathways. A linear relationship was obtained for granulocyte/macrophage col...
journal_title:Acta haematologica
pub_type: 杂志文章
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journal_title:Acta haematologica
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journal_title:Acta haematologica
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journal_title:Acta haematologica
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journal_title:Acta haematologica
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journal_title:Acta haematologica
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journal_title:Acta haematologica
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journal_title:Acta haematologica
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abstract::A 28-year-old woman with Bence-Jones multiple myeloma (MM) presented with several osteolytic lesions and a massive bone marrow infiltration with mature plasmocytes. After 6 cycles of chemotherapy with melphalan and prednisone, the patient, in apparent clinical remission, underwent allogeneic bone marrow transplantatio...
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journal_title:Acta haematologica
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journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204727
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journal_title:Acta haematologica
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journal_title:Acta haematologica
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journal_title:Acta haematologica
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journal_title:Acta haematologica
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更新日期:1979-01-01 00:00:00
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pub_type: 杂志文章
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