Skin window cellularity and macrophage changes in Hodgkin's and non-Hodgkin's lymphomas.

abstract：:Recent molecular biological investigations have shown that genetic information on the short arm of chromosome 17 is frequently deleted or inactivated in acute myeloid leukaemias and a number of solid tumours. In earlier studies we have found clonal occurrence of a 17p deletion (17p-) in patients with refractory anaemi...

journal_title：Acta haematologica

authors： Pedersen B,Kerndrup G

更新日期：1990-01-01 00:00:00

abstract：:The presence of the sickle cell (Hb S) gene in Saudi Arabia was first reported by Lehmann et al. in 1963 [Nature 198, pp. 492-493]. Later, Hb S, alpha- and beta-thalassaemia, glucose-6-phosphate dehydrogenase deficiency and other enzymopathies were shown to occur at a variable prevalence in different regions of the co...

journal_title：Acta haematologica

authors： el-Hazmi MA

更新日期：1987-01-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) is thought to take part in the genesis of bone marrow fibrosis that can be found in patients with myeloproliferative diseases. We evaluated platelet mitogenic activity as the difference between serum and plasma activity in 8 patients with myeloproliferative disease. We observed a ...

journal_title：Acta haematologica

authors： Caenazzo A,Pietrogrande F,Polato G,Piva E,Masiero M,Sgarabotto D,Girolami A

更新日期：1989-01-01 00:00:00

abstract：:An increased bone marrow (BM) apoptosis is one of the mechanisms responsible for the ineffective hematopoiesis of myelodysplastic syndromes (MDS). It is controversial whether the excessive apoptosis in myelodysplasia predominantly involves the subset of progenitor cells or of maturing cells. We investigated the degree...

journal_title：Acta haematologica

authors： Pecci A,Travaglino E,Klersy C,Invernizzi R

更新日期：2003-01-01 00:00:00

abstract：:During a screening for hemoglobinopathies, we found a carrier of the Sardinian δβ-thalassemia condition. The proband's hematology and hemoglobin (Hb) profile agreed with those of the other carriers previously identified during our diagnostic program except for the fetal Hb (HbF) composition, which consisted of both α2...

journal_title：Acta haematologica

authors： Trova S,Mereu P,Cocco E,Masala B,Manca L,Pirastru M

更新日期：2016-01-01 00:00:00

abstract：:A new variant of red cell glucose-6-phosphate dehydrogenase (G6PD) has been found in a Caucasian man with congenital non-spherocytic haemolytic anaemia. This variant has reduced activity, increased thermolability, increased Michaelis constants for glucose-6-phosphate and NADP, slightly increased electrophoretic mobili...

journal_title：Acta haematologica

authors： Mandelli F,Amadori S,De Laurenzi A,Kahn A,Isacchi G,Papa G

更新日期：1977-01-01 00:00:00

abstract：:We have studied the amount and intracellular distribution of erythroblastic alkaline and acid phosphatase, nonspecific esterase, and N-acetyl-beta-glucosaminidase in 50 patients with acquired dyserythropoiesis. 19 morphologically normal bone marrow smears served as controls. Alkaline phosphatase was found in all contr...

journal_title：Acta haematologica

authors： Woessner S,Lafuente R,Florensa L,Sans-Sabrafen J

更新日期：1984-01-01 00:00:00

abstract：:Pyrimidine 5'-nucleotidase (P5'N) partial deficiency has been described in several hematological disorders and also in the beta-thalassemic trait. To check if the P5'N deficiency in thalassemia was acquired we used thalassemic red cells (from either homo- or heterozygous subjects), whose P5'N activity was lower than i...

journal_title：Acta haematologica

authors： David O,Vota MG,Piga A,Ramenghi U,Bosia A,Pescarmona GP

更新日期：1989-01-01 00:00:00

abstract：:Multiple myeloma (MM) is a B cell malignancy characterized by accumulation of plasma cells (PCs) in the bone marrow. Traditional methods for the detection of minimal residual disease (MRD) measure the presence of monoclonal immunoglobulin protein secreted by the malignant PCs. However, changes in the level of MRD in M...

journal_title：Acta haematologica

authors： Rasmussen T,Knudsen LM,Huynh TK,Johnsen HE

更新日期：2004-01-01 00:00:00

abstract：:The objective of this study was to assess the pharmacokinetics of rhG-CSF after a single intraperitoneal injection 2 h post-TBI in B6D2F1 lethally irradiated mice and to analyze the effect of rhG-CSF on the endogenous response of interleukin-3 (IL-3), interleukin-6 (IL-6) and granulocyte-macrophage colony-stimulating ...

journal_title：Acta haematologica

authors： Kádár E,Sureda A,Mangues MA,Inglés-Esteve J,Valls A,García J

更新日期：1997-01-01 00:00:00

abstract：:We investigated double (specific and nonspecific) esterase (DE) staining in marrow cells of 237 patients with the myelodysplastic syndromes (MDS). Additional abnormalities of neutrophilic granules were examined cytochemically and immunocytochemically for myeloperoxidase activity and antigen elastase, lactoferrin and C...

journal_title：Acta haematologica

authors： Elghetany MT,Peterson B,MacCallum J,Nelson DA,Varney JF,Sullivan AK,Silverman LR,Schiffer CA,Davey FR,Bloomfield CD

更新日期：1998-01-01 00:00:00

abstract：:The effects of lithium on the microtubular and microfilament systems of neutrophil granulocytes is described. The phagocytic capacity of human neutrophils was reduced or inhibited by using vinblastine or cytochalasin B. Lithium at concentrations ranging from 0.5 to 2.0 mEq/l proved to be capable of antagonising the ac...

journal_title：Acta haematologica

authors： Carulli G,Marini A,Azzarà A,Petrini M,Ruocco L,Ambrogi F

更新日期：1985-01-01 00:00:00

abstract：:Progenitor cell fractions from normal human marrow have been prepared by a method that enables low numbers of cells to be cultured and results in very little T cell or monocyte contamination. The enrichment of 14- and 21-day BFU-E was similar to that for CFU-GM and the readdition of sheep red blood rosette-forming cel...

journal_title：Acta haematologica

authors： Linch DC,Boyle D,Beverley PC

更新日期：1982-01-01 00:00:00

abstract：:The detection of cellular antigens in bone marrow sections depends on the method of embedding, the nature of antigen and antibody, antigen retrieval techniques and the sensitivity of the immunohistochemical method. This study evaluated a fluorescyl-tyramide-enhanced immunostaining method on methyl-methacrylate-embedde...

journal_title：Acta haematologica

authors： Gaiser T,Bernhards J

更新日期：2007-01-01 00:00:00

abstract：:Cancer patients not undergoing treatment and without a history of venous thrombosis do not, as a general rule, require prophylaxis. However, venous thromboembolism is of sufficient magnitude in patients undergoing treatment for cancer for thromboprophylaxis to be routinely employed. The mainstay of primary prevention ...

journal_title：Acta haematologica

authors： Thodiyil PA,Walsh DC,Kakkar AK

更新日期：2001-01-01 00:00:00

abstract：:Essential thrombocythemia (ET), one of the chronic myeloproliferative disorders, is a clonal disorder of multipotent stem cells. Although most patients with ET have a prolonged benign course, a minority of patients may develop a blastic crisis similar to chronic myelogenous leukemia (CML). A case of ET terminating in ...

journal_title：Acta haematologica

authors： Shibata K,Shimamoto Y,Suga K,Sano M,Matsuzaki M,Yamaguchi M

更新日期：1994-01-01 00:00:00

abstract：:Leukemic cells of a patient with acute T-lymphoblastic leukemia (T-ALL) exhibiting the uncommon clinical feature of hypogammaglobulinemia were examined in terms of surface markers and immunologic functions. Employing various monoclonal reagents reacting with surface antigens present on T cells and additional conventio...

journal_title：Acta haematologica

authors： Herrmann F,Sieber G,Komischke B,Oestreich R,Rühl H

更新日期：1984-01-01 00:00:00

abstract：:Mesenteric panniculitis is a rare idiopathic inflammatory disorder that can lead to sclerosis. We describe a patient with mesenteric panniculitis presenting with abdominal symptoms and autoimmune haemolytic anaemia. The symptoms remitted after splenectomy and gradual steroid taper. This may suggest an autoimmune compo...

journal_title：Acta haematologica

authors： Vidarsson B,Matthíasson P,Agnarsson BA,Onundarson PT

更新日期：2002-01-01 00:00:00

abstract：:Malaria parasites growing inside human erythrocytes differ from mammalian cells in their mode of acquisition of bioavailable iron and in their susceptibility to the antiproliferative action of iron chelators. We have assessed here three major properties associated with these phenomena: (a) the stage-dependent nature o...

journal_title：Acta haematologica

authors： Cabantchik ZI,Glickstein H,Golenser J,Loyevsky M,Tsafack A

更新日期：1996-01-01 00:00:00

abstract：:This paper presents data on the occurrence and pattern of inherited bleeding syndromes (IBS) in Jordan, a hitherto unexplored problem. In 1978, during the first 12 months of a prospective study at a major medical center, 91 patients from 51 families were diagnosed as having IBS. All patients were referred because of m...

journal_title：Acta haematologica

authors： Alsabti EA,Hammadi M

更新日期：1979-01-01 00:00:00

abstract：:We have demonstrated that hemopoietic organ fibroblastoid cells can produce colony-stimulating activity (CSA) in vitro. Skin fibroblasts also produced CSA. The colonies which formed were restricted to the granulocyte/macrophage differentiation pathways. A linear relationship was obtained for granulocyte/macrophage col...

journal_title：Acta haematologica

authors： Brockbank KG,van Peer CM

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this work was to investigate the efficacy and predictive factors of CLAG treatment in refractory or relapsed (R/R) acute myeloid leukemia (AML) patients. METHODS:Sixty-seven R/R AML patients were enrolled in this prospective cohort study and treated by a CLAG regimen: 5 mg/m2/day cladribine ...

journal_title：Acta haematologica

authors： Wang L,Xu J,Tian X,Lv T,Yuan G

更新日期：2019-01-01 00:00:00

abstract：:Primary plasma cell leukemia (PCL) is a rare form of plasma cell neoplasm with a poor prognosis. Conventional melphalan-based treatments have been most disappointing. We report the case of a 62-year-old man with a primary form of PCL treated with VAD combination achieving an objective response, and who received high-d...

journal_title：Acta haematologica

authors： Panizo C,Rifón J,Rodríguez-Wilhelmi P,Cuesta B,Rocha E

更新日期：1999-01-01 00:00:00

abstract：:Automated cytochemistry by the Hemalog D carries out leukocyte differential counts in a continuous flow mode on whole blood EDTA-collected samples, through the optical measurement of enzyme activity and cell size. This operative principle thus parallels the basis of the FAB classification of acute leukemias. Although ...

journal_title：Acta haematologica

authors： d'Onofrio G,Mango G

更新日期：1984-01-01 00:00:00

abstract：:Sera from 154 hemophiliacs, including 132 with hemophilia A and 22 with hemophilia B, were examined for antibodies against human T cell lymphotropic virus type III (HTLV-III) and type I by strip radioimmunoassay based on the Western blotting technique. Sixty-two patients lived in Kyushu, a known endemic area of HTLV-I...

journal_title：Acta haematologica

authors： Hattori T,Ikematsu S,Chosa T,Yamamoto S,Matsuoka M,Fukutake K,Robert-Guroff M,Takatsuki K

更新日期：1987-01-01 00:00:00

abstract：:Analysis of donor chimerism has become a routine method for the documentation of engraftment after allogeneic hematopoietic stem cell transplantation (HSCT). In recent years several groups have also focused on the application of this technique for the detection of relapsing disease after allogeneic HSCT. This review a...

journal_title：Acta haematologica

authors： Thiede C,Bornhäuser M,Ehninger G

更新日期：2004-01-01 00:00:00

abstract：:A 74-year-old woman was treated by lithium carbonate 3 x 300 mg per day for drug-induced aplastic anemia. After 8 days, she suddenly developed severe impairment of consciousness with myoclonias and hypertonia which persisted during 10 days despite lithium withdrawal and sodium chloride infusion. Slight disorders of wa...

journal_title：Acta haematologica

authors： Efira A,van Laethem Y,Ectors M,Unger J

更新日期：1980-01-01 00:00:00

abstract：:Recently, the use of novel targeted drugs has changed the treatment paradigms in chronic lymphocytic leukemia (CLL). Among the several drugs used for the management of relapsed/refractory (R/R) CLL, Bruton tyrosine kinase inhibitors (ibrutinib and acalabrutinib), phosphatidylinositol 3-kinase inhibitors (idelalisib an...

journal_title：Acta haematologica

authors： Smolewski P,Robak T

更新日期：2020-11-25 00:00:00

abstract：:34 patients with myocardial infarction were studied with daily measurements of beta-thromboglobulin (BTG) and 125I fibrinogen scanning in order to detect deep-venous thrombosis (DVT). Serial levels of BTG were unhelpful in the early detection of this condition, which occurred in 7 of the patients studied. 5 of the pat...

journal_title：Acta haematologica

authors： Simmonds JP,O'Malley BP,Maskill MR,O'Connor JF,Burridge DJ

更新日期：1980-01-01 00:00:00

abstract：:Immunoglobulin light chain amyloidosis (AL amyloidosis) is a rare, life-threatening disease characterized by the deposition of misfolded proteins in vital organs such as the heart, the lungs, the kidneys, the peripheral nervous system, and the gastrointestinal tract. This causes a direct toxic effect, eventually leadi...

journal_title：Acta haematologica

authors： Van Doren L,Lentzsch S

更新日期：2020-01-01 00:00:00