Abstract:
:The clinical pattern of haemolysis associated with Donath-Landsteiner antibodies has undergone a change over the years. In the current study 13 patients developed the acute form of the disease whilst only 1 presented with the classical picture of chronic paroxysmal cold haemoglobinuria. The acute illness typically occurred in young children with a male predominance of about 2.5:1; 10 patients were less than 5 years old. There was often a history of a preceding infection, the onset was sudden, prostration, haemoglobinuria and pallor were prominent. The patients were very ill but rapid and complete recovery usually occurred within a few days; however, 1 patient died. Treatment consisted of rest and warmth; in addition blood transfusion was needed in 7 patients. The chronic disease (which was non-syphilitic in origin) followed a benign course, warmth and avoidance of cold being all that were necessary to maintain the patient's well-being. It is felt that the general term for this disorder should be Donath-Landsteiner haemolysis rather than the traditional paroxysmal cold haemoglobinuria.
journal_name
Acta Haematoljournal_title
Acta haematologicaauthors
Sokol RJ,Hewitt S,Stamps BKdoi
10.1159/000206992subject
Has Abstractpub_date
1982-01-01 00:00:00pages
268-77issue
4eissn
0001-5792issn
1421-9662journal_volume
68pub_type
杂志文章abstract::A 69-year-old woman presented with chronic lymphocytic leukemia (CLL) diagnosed after bone marrow recovery following intensive chemotherapy for acute lymphoblastic leukemia. The retrospective diagnosis of initial blastic transformation of CLL was made. The patient eventually died, 5 months after initial blastic phase,...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205751
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更新日期:2020-10-02 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2009-01-01 00:00:00
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journal_title:Acta haematologica
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更新日期:1983-01-01 00:00:00
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更新日期:1985-01-01 00:00:00
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更新日期:2007-01-01 00:00:00
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doi:10.1159/000102588
更新日期:2007-01-01 00:00:00
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journal_title:Acta haematologica
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更新日期:2001-01-01 00:00:00
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journal_title:Acta haematologica
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更新日期:1984-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
abstract::Eltrombopag is a thrombopoietin receptor agonist frequently used to manage immune thrombocytopenia and aplastic anemia. At the high doses used for aplastic anemia, but not the doses used for immune thrombocytopenia, eltrombopag can cause reddish-brown discoloration of plasma, which can interfere with bilirubin measure...
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更新日期:2020-07-22 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
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journal_title:Acta haematologica
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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更新日期:2003-01-01 00:00:00