Increased proportion of HLA-class-I-specific natural killer cell receptors (CD94) on peripheral blood mononuclear cells after allogeneic bone marrow transplantation.

Abstract:

:In the present study, we investigated the inhibitory natural killer cell receptor (NKR) expression of CD94/NKG2A on PBMC after allogeneic bone marrow transplantation (BMT). The proportion of CD94 expression on PBMC was higher in patients without chronic graft-versus-host disease (cGVHD) and also in cGVHD patients with good response to conventional immunosuppressive therapy than in cGVHD patients with poor response. Also, the proportions of CD94+/CD3+ cells and CD94+/CD8+ cells were higher in cGVHD patients showing good response. In addition, the proportion of NKG2A-expressing cells was higher in patients without cGVHD than in patients with cGVHD. Therefore, chronic allostimulation after allo-BMT may augment the proportion of CD94/NKG2A-positive cells, and these cells may play some role in the regulation of alloresponse in some patients.

journal_name

Acta Haematol

journal_title

Acta haematologica

authors

Tanaka J,Tutumi Y,Zhang L,Mori A,Kahata K,Toyoshima N,Ohta S,Kobayashi S,Hashino S,Asaka M,Imamura M

doi

10.1159/000046540

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

89-91

issue

2

eissn

0001-5792

issn

1421-9662

pii

46540

journal_volume

105

pub_type

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