Characterization of the fibrinolytic state by measuring stable cross-linked fibrin degradation products in disseminated intravascular coagulation associated with acute promyelocytic leukemia.

Abstract:

:Plasma samples from patients with disseminated intravascular coagulation (DIC) associated with acute promyelocytic leukemia (APL) exhibited higher levels of the D-fragment of fibrin and fibrinogen degradation products [FDP(D)], with relatively lower levels of cross-linked fibrin degradation products (XDP), than samples of DIC with non-APL. The difference between FDP(D) and XDP levels increased only when alpha 2-plasmin inhibitor (alpha 2-PI) fell below 60% of the normal level in APL patients. These findings suggest that fibrinogenolysis occurs in APL patients when the alpha 2-PI level has decreased significantly.

journal_name

Acta Haematol

journal_title

Acta haematologica

authors

Okajima K,Koga S,Okabe H,Inoue M,Takatsuki K

doi

10.1159/000205392

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

15-8

issue

1

eissn

0001-5792

issn

1421-9662

journal_volume

81

pub_type

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