Abstract:
:Acute myeloid leukemia (AML) is a stem cell malignancy that originates in the bone marrow and involves the peripheral blood. Extramedullary AML is rarer, but it is most commonly associated with the former French-American-British (FAB) subtypes M4 or M5 of AML. AML cells may also home to the central nervous system and other solid organs such as cortical bone and skin. Such target sites of metastasis depend on microenvironmental niche interactions, which have not been fully elucidated to date. Visceral organs usually do not represent a favorable niche for AML stem cell occupancy. Herein, we describe the case of an 80-year-old man with extramedullary AML involvement of the renal pelvis. Hypercalcemia and obstructive uropathy were presenting features. The visceral niche is a rare site of involvement of myeloid malignancy, and hypercalcemia may reflect a mechanism of extramedullary involvement. We propose a treatment paradigm for this uncommon subset of AML based on advanced age and complex karyotype.
journal_name
Acta Haematoljournal_title
Acta haematologicaauthors
Patel SA,Bledsoe JR,Gordon J,Cerny Jdoi
10.1159/000508526subject
Has Abstractpub_date
2020-08-19 00:00:00pages
1-5eissn
0001-5792issn
1421-9662pii
000508526pub_type
abstract::Thrombopoietin levels in thrombocytopenic mice assayed by 75Se-se-lenomethionine incorporation into blood platelets reached a maximum 12 h after the induction of an acute, immune thrombocytopenia; that was more than twice the value in control mice. The implications of this finding are discussed with reference to the k...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000208096
更新日期:1975-01-01 00:00:00
abstract::This paper presents data on the occurrence and pattern of inherited bleeding syndromes (IBS) in Jordan, a hitherto unexplored problem. In 1978, during the first 12 months of a prospective study at a major medical center, 91 patients from 51 families were diagnosed as having IBS. All patients were referred because of m...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207625
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:Adherence to tyrosine kinase inhibitor treatment is a significant factor in the achievement of a good clinical response in chronic myeloid leukemia (CML). The aim of this retrospective study is to investigate 1- and 2-year medication adherence to imatinib treatment, linking adherence rates with the clinical o...
journal_title:Acta haematologica
pub_type: 评论,杂志文章
doi:10.1159/000444626
更新日期:2016-01-01 00:00:00
abstract::Serum IgG, IgM and IgA were determined in 25 patients with homozygous beta thalassemia and 7 with the trait. The levels were increased in homozygous patients and increased further after splenectomy. Serum opsonic activity against Salmonella typhi and staphylococci was impaired in homozygous patients. Splenectomy cause...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206875
更新日期:1983-01-01 00:00:00
abstract::Plasma samples from patients with disseminated intravascular coagulation (DIC) associated with acute promyelocytic leukemia (APL) exhibited higher levels of the D-fragment of fibrin and fibrinogen degradation products [FDP(D)], with relatively lower levels of cross-linked fibrin degradation products (XDP), than sample...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205392
更新日期:1989-01-01 00:00:00
abstract::We describe a patient with hemophagocytic syndrome resembling malignant histiocytosis which was complicating myelodysplastic disease of 3 years duration. Detailed morphological and ultrastructural studies indicate that the histiocytic component did not demonstrate features of malignancy. A review of other known malign...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206198
更新日期:1985-01-01 00:00:00
abstract::A 12-year-old male of Chinese ancestry had life-long hemolytic anemia attributed to alpha-thalassemia. Restriction endonuclease mapping of his DNA revealed that in reality, he had three alpha-globin loci, but he was homozygous for pyruvate kinase deficiency. The new pyruvate kinase variant carried by this patient was ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206830
更新日期:1983-01-01 00:00:00
abstract::In a dose titration study we tested the efficacy and tolerance of recombinant human erythropoietin (rhEPO) in 10 patients with myelodysplasia (MDS) and 2 patients with idiopathic myelofibrosis. Patients with a haemoglobin level < 100 g/l were treated as out-patients for 12 weeks with daily doses ranging from 30 U/kg b...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204378
更新日期:1993-01-01 00:00:00
abstract::Iron deficiency is the main cause of anemia in both sexes, with women being more commonly affected. Iron therapy is currently considered an effective and safe remedy to replenish the iron storages. Iron can be administrated both orally and intravenously. In particular, intravenous (IV) iron therapy is widely used when...
journal_title:Acta haematologica
pub_type:
doi:10.1159/000503768
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Reticulated platelets circulating in the blood reflect megakaryopoietic activity and platelet turnover and can be automatically and low-invasively measured as the immature platelet fraction (IPF) using a Sysmex XN hematocytometer. The present study retrospectively investigated whether or not the IPF can pred...
journal_title:Acta haematologica
pub_type: 新闻
doi:10.1159/000510460
更新日期:2020-09-17 00:00:00
abstract::B6D2F1 female mice were intravenously administered 0.4 mg of glucan. 1, 5, 11, and 17 days later, the total nucleated cellularity (TNC) and the numbers of pluripotent hemopoietic stem cells (CFU-s), granulocyte-macrophage progenitor cells (GM-CFC), and erythroid colony-forming (CFU-e) and burst-forming (BFU-e) cells w...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206753
更新日期:1983-01-01 00:00:00
abstract::A patient with acute monoblastic leukemia developed a coagulopathy during chemotherapy. Coagulation studies showed thrombocytopenia, hypofibrinogenemia, high levels of fibrinogen degradation products, a negative protemine test but a normal antithrombin III level. These observations suggest that coagulation abnormaliti...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207433
更新日期:1980-01-01 00:00:00
abstract::Two family members (daughter and mother) with a bleeding disorder showed prolonged bleeding time and activated partial thromboplastin time associated with decreased plasma levels of factor VIII procoagulant activity, factor VIII-related antigen, and factor VIII-ristocetin cofactor activity. The ristocetin-induced plat...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206579
更新日期:1984-01-01 00:00:00
abstract::10 patients with paroxysmal nocturnal hemoglobinuria were studied taking 109 normal subjects of the Cuban population as control group. 26 HLA antigens corresponding to loci A and B were studied in both groups. Phenotypical frequency of both groups were compared. No statistically significant increase was found for any ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207369
更新日期:1980-01-01 00:00:00
abstract::Hypercalcemia is a significant feature of patients with active multiple myeloma (MM) with extensive bone disease. Among the causes of non-neoplastic hypercalcemia, primary hyperparathyroidism (PHPT) is one of the most common, leading to osteoporosis and bone fractures. Interestingly, some preclinical data indicate tha...
journal_title:Acta haematologica
pub_type:
doi:10.1159/000509768
更新日期:2020-09-09 00:00:00
abstract::In 34 patients with chronic lymphatic leukaemia (CLL) the lymphocytes have been separated and sized using a C1000 Channelyzer. The modal volume and the volume range of the populations have been obtained and related to clinical stage and mouse red blood cell (MRBC) rosetting capacity. Over 1 year's observation with sev...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206714
更新日期:1983-01-01 00:00:00
abstract::A 16-year-old Japanese woman with acute myelogenous leukemia (AML) and t(6;9) received peripheral blood stem cell transplantation (PBSCT). Although chromosomal studies just prior to and following PBSCT showed a normal karyotype, reverse transcription-polymerase chain reaction (RT-PCR) detected the mRNA derived from th...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000203996
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND/AIMS:The study was undertaken to understand the characteristic of plasma cell leukemia (PCL) in China. METHODS:We reviewed and compared medical data of 22 primary PCL, 9 secondary PCL and 461 multiple myeloma (MM) diagnosed at our institute from January 2000 to January 2008. RESULTS:The median onset ages o...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000210555
更新日期:2009-01-01 00:00:00
abstract::The cutaneous inflammatory response in patients with Hodgkin's and non-Hodgkin's lymphomas was investigated by light and scanning electron microscopy and compared with that of healthy subjects at 24 and 48 h. Both groups of patients showed a reduction in overall cellularity and statistically significant differences in...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207253
更新日期:1980-01-01 00:00:00
abstract::Bone marrow samples of 28 individuals with clinically benign and of 41 patients with malignant monoclonal gammopathy were analyzed for the total number of lymphoplasmocellular elements containing cytoplasmic immunoglobulins and for the monoclonal fraction of these cells. Monoclonal immunoglobulin components were deter...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207709
更新日期:1978-01-01 00:00:00
abstract::A 3-year-old child developed severe aplastic anaemia following hepatitis A. Since no HLA-compatible donor was available, he was treated with oxymetholone, antithymocytic globulin and methylprednisolone, but no haematologic recovery was observed and he consequently died of pneumonia. Although the association of aplasti...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206061
更新日期:1986-01-01 00:00:00
abstract::The activity of ten red blood cell enzymes, including hexokinase, has been measured in 6 Fanconi's anemia patients. In disagreement with previous reports, in no instance were reduced or increased hexokinase levels found. Furthermore, the hexokinase isozymic pattern, thermostability, pH dependence of activity and kinet...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206612
更新日期:1984-01-01 00:00:00
abstract::96 consecutive acute myelogenous leukemia (AML) patients were analyzed retrospectively with regard to the regimen used for remission induction. 35 patients received daunorubicin for 3 days, cytosine arabinoside and 6-thioguanine for 7 days. 61 were treated with the same regimen but 6-thioguanine was replaced by etopos...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205173
更新日期:1990-01-01 00:00:00
abstract::The effect of methylprednisolone on fresh cells from patients with chronic lymphocytic leukaemia (CLL) has been studied using the differential staining cytotoxicity (DiSC) assay resulting in LC90s of < or = 0.2 to 2,000 micrograms/ml. Cells from previously treated patients were, on average, significantly more sensitiv...
journal_title:Acta haematologica
pub_type: 临床试验,杂志文章
doi:10.1159/000204115
更新日期:1995-01-01 00:00:00
abstract::Allogeneic stem cell transplantation (SCT) is the treatment of choice for selected patients with chronic myeloid leukemia (CML). However, it is associated with a high risk of treatment-related mortality (TRM) and morbidity. To assist in decision making about transplantation, a simple scoring system to assess the risk ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000069283
更新日期:2003-01-01 00:00:00
abstract::A case of multiple pyarthroses due to Staphylococcus aureus occurring in a severe classical hemophiliac is presented. Successful management depended on drainage of the infected joints and a prolonged course of antibiotics. Several criteria are suggested for recognition of hemophiliacs who might benefit from joint aspi...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206569
更新日期:1984-01-01 00:00:00
abstract::A 59-year-old man with beta-thalassaemia major is unusually well. He has no beta-chains in his haemoglobin but is heterozygous for the genes responsible for alphaA and for alphaG Philadelphia. In addition he is also heterozygous for the genes responsible for gammaF and a new gamma-chain, gamma75(E19) Ile-Thr, named ga...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000208204
更新日期:1975-01-01 00:00:00
abstract::Natural killer (NK) cell activity against K562 cell targets and the distribution of T cell subpopulations were investigated in the peripheral blood of 25 patients affected by beta thalassemia major, 18 clinically healthy heterozygotes, and 25 age-matched normal subjects. It was found that thalassemia major patients di...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206598
更新日期:1984-01-01 00:00:00
abstract::Fetal hemoglobin (HbF) concentrations were measured by a radial immunodiffusion assay in 233 patients with various malignancies. In 96 of these, alpha-fetoprotein (AFP) was also measured by radioimmunoassay. The concentration of HbF exceeded 2 SDs above the normal mean in 39 of 233 patients, most notably in patients w...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207839
更新日期:1977-01-01 00:00:00
abstract::There have been many reports of patients with ampulla cardiomyopathy described as takotsubo-shaped cardiomyopathy in the cardiovascular field. This unique cardiomyopathy is characterized by transient apical ballooning and hypokinesis of the left ventricle. We describe 2 cases of ampulla cardiomyopathy associated with ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000098461
更新日期:2007-01-01 00:00:00