Low-dose recombinant alfa-2a-interferon: a feasible maintenance therapy in acute myeloid leukaemia in the older patient.

abstract：:Haemoglobin synthesis was studied in bone marrow erythroblasts and in reticulocytes of 4 children with beta O-thalassaemia major and of 7 children with beta +-thalassaemia major. In patients with beta O-thalassaemia the gamma/a ratio was found to be lower in bone marrow than in peripheral blood. On the contrary, in pa...

journal_title：Acta haematologica

authors： Musumeci S,Schilirò G,Romeo MA,Pizzarelli G,Fischer A,Russo G

更新日期：1981-01-01 00:00:00

abstract：:Total and unsaturated folate binding capacity (TFBC, UFBC) have been measured in sera of selective groups of patients to study the role of cell turnover, cell necrosis and the effect of pregnancy in determining their concentrations in blood. The mean value of TFBC in 35 normal sera was 151 +/- (SD) 53 pg/ml with a sat...

journal_title：Acta haematologica

authors： Corrocher R,Bambara LM,Pachor ML,Biasi D,Stanzial A,De Sandre G

更新日期：1979-01-01 00:00:00

abstract：:Treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute leukemia (Ph+ ALL) has been revolutionized with the advent of tyrosine kinase inhibitors (TKIs). Most patients with CML achieve long-term survival similar to individuals without CML due to treatment with TKIs not only in frontline b...

journal_title：Acta haematologica

authors： Saussele S,Haverkamp W,Lang F,Koschmieder S,Kiani A,Jentsch-Ullrich K,Stegelmann F,Pfeifer H,La Rosée P,Goekbuget N,Rieger C,Waller CF,Franke GN,le Coutre P,Kirchmair R,Junghanss C

更新日期：2020-01-01 00:00:00

abstract：:Systematic reviews and meta-analyses have made a major contribution to the evidence-based management of infections in cancer patients. We review the contribution of systematic reviews with regard to antibiotic, antifungal, antiviral and Pneumocystis pneumonia prophylaxis; antibiotic and antifungal treatment of febrile...

journal_title：Acta haematologica

authors： Paul M,Gafter-Gvili A,Goldberg E,Yahav D

更新日期：2011-01-01 00:00:00

abstract：:Thalidomide acts on the microenvironment of myelodysplastic syndromes (MDS) by influencing cytokine networks, and growing evidence supports thalidomide's usefulness in the management of haematological malignancies, such as MDS. The European Collaboration Group on Myelofibrosis with Myeloid Metaplasia reviewed patients...

journal_title：Acta haematologica

authors： Prentice HG,Sacchi S,Russell N

更新日期：2005-01-01 00:00:00

abstract：:The plasminogen activator content of a vein wall has been measured by estimating the radio-activity released from a 125I-tagged fibrin clot by incubating that clot with a known weight of the vein wall. This method could be used in the investigation of the fibrinolytic system of the body in its normal distribution and ...

journal_title：Acta haematologica

authors： Johnson RH,Mansfield AO

更新日期：1978-01-01 00:00:00

abstract：:It was found that neutrophils in untreated uraemic patients as well as in subjects on regular dialysis treatment displayed higher activity of acid phosphatase, alkaline phosphatase and peroxidase. Spontaneous reduction of nitro blue tetrazolium (NBT) by granulocytes was also higher in both groups in comparison to cont...

journal_title：Acta haematologica

authors： Sutowicz W,Komorowska Z,Hanicki Z,Cichocki T,Smoleński O

更新日期：1979-01-01 00:00:00

abstract：:Twenty-four infants and children suffering from glucose-6-phosphate dehydrogenase (G6PD) deficiency during hemolytic crisis were included in this study. Their ages ranged between 3 and 36 months with a median of 10 months. 22 were males and 2 were females. Fourteen out of them received a single bolus dose of desferrio...

journal_title：Acta haematologica

authors： Khalifa AS,el-Alfy MS,Mokhtar G,Fakeir AA,Khazbak MA,el-Baz F,el-Kholy M

更新日期：1989-01-01 00:00:00

abstract：:Drug-induced immune hemolytic anemia is a rare but underdiagnosed and potentially fatal condition. We report a case of severe hemolytic anemia induced by cefoxitin in a 45-year-old woman admitted with menometrorrhagia. Hemoglobin levels reached a nadir of 4.7 g/dl approximately 72 h after cefoxitin initiation, and hem...

journal_title：Acta haematologica

authors： Leaf DE,Langer NB,Markowski M,Garratty G,Diuguid DL

更新日期：2010-01-01 00:00:00

abstract：:We describe in this paper a female patient affected by chronic granulomatous disease with all the features of the classic X-linked form of the disease and presenting a mild form of the disease, the major clinical manifestation being a granulomatous cheilitis. The capability of the patient's phagocytes to undergo a res...

journal_title：Acta haematologica

authors： Dusi S,Poli G,Berton G,Catalano P,Fornasa CV,Peserico A

更新日期：1990-01-01 00:00:00

abstract：:Richter syndrome (RS) describes the development of high-grade non-Hodgkin's lymphoma (NHL) from low-grade NHL. RS isolated to the brain is very rare and has a poor prognosis. We describe the cases of high-grade large B-cell diffuse NHL in a 56-year-old male with chronic lymphocytic leukemia and in a 71-year-old female...

journal_title：Acta haematologica

authors： Stuplich M,Mayer K,Kim Y,Thanendrarajan S,Simon M,Schäfer N,Glas M,Schmidt-Wolf IG,Herrlinger U

更新日期：2012-01-01 00:00:00

abstract：:Basic fibroblast growth factor (b-FGF) mediates a variety of biological responses such as angiogenesis and hematopoiesis. We examined the effect of b-FGF on human neutrophil functions in vitro. The surface expression of effector cell molecules on neutrophils was determined by flow cytometry and monoclonal antibodies. ...

journal_title：Acta haematologica

authors： Takagi S,Takahashi K,Katsura Y,Matsuoka T,Ohsaka A

更新日期：2000-01-01 00:00:00

abstract：:Increased levels of hemoglobin A(2) (HbA(2)) are present in most beta-thalassemia carriers. The mechanism of this effect is not understood, although the increase may result from transcriptional and posttranscriptional changes. In the present study, we quantitate delta-globin mRNA levels in peripheral-blood-enriched re...

journal_title：Acta haematologica

authors： Huang SZ,Zeng FY,Chen MJ,Ren ZR,Shen M,Rodgers GP,Schechter AN,Zeng YT

更新日期：1999-01-01 00:00:00

abstract：:Although multiple myeloma (MM) remains an incurable disease, its treatment has improved over the past decade. This improvement has been at least in part due to the introduction of novel antimyeloma agents with new mechanisms of action, including those that target both myeloma cells and the tumor microenvironment, with...

journal_title：Acta haematologica

authors： Cibeira MT,Mercadal S,Arenillas L,Muntañola A,Salamero O,Bladé J

更新日期：2006-01-01 00:00:00

abstract：:The presence of the sickle cell (Hb S) gene in Saudi Arabia was first reported by Lehmann et al. in 1963 [Nature 198, pp. 492-493]. Later, Hb S, alpha- and beta-thalassaemia, glucose-6-phosphate dehydrogenase deficiency and other enzymopathies were shown to occur at a variable prevalence in different regions of the co...

journal_title：Acta haematologica

authors： el-Hazmi MA

更新日期：1987-01-01 00:00:00

abstract：:The objective of this study was to assess the pharmacokinetics of rhG-CSF after a single intraperitoneal injection 2 h post-TBI in B6D2F1 lethally irradiated mice and to analyze the effect of rhG-CSF on the endogenous response of interleukin-3 (IL-3), interleukin-6 (IL-6) and granulocyte-macrophage colony-stimulating ...

journal_title：Acta haematologica

authors： Kádár E,Sureda A,Mangues MA,Inglés-Esteve J,Valls A,García J

更新日期：1997-01-01 00:00:00

abstract：:We describe two kindreds of Arab ancestry characterized by multiple cases of acute lymphoblastic leukemia. Consanguinity and intermarriages were prevalent in the two families. Age, mode of presentation, characteristics of the leukemic cells, response to treatment and prognosis were remarkably similar among the patient...

journal_title：Acta haematologica

authors： Kende G,Toren A,Mandel M,Neumann Y,Kenet G,Brok-Simoni F,Ramot B,Ben-Bassat I,Rechavi G

更新日期：1994-01-01 00:00:00

abstract：:10 patients with paroxysmal nocturnal hemoglobinuria were studied taking 109 normal subjects of the Cuban population as control group. 26 HLA antigens corresponding to loci A and B were studied in both groups. Phenotypical frequency of both groups were compared. No statistically significant increase was found for any ...

journal_title：Acta haematologica

authors： Ustariz CR,Arce S,Hernández P,Almaguer M,Pérez S,Ballester JM

更新日期：1980-01-01 00:00:00

abstract：:We evaluated an enzyme-linked immunosorbent assay (ELISA) for embryonic zeta-globin chains as a routine screening test for (--(SEA)) alpha-thalassemia deletion (SEA deletion). A total of 174 consecutive patient samples with a request for Hb analysis were recruited. The ELISA method was evaluated against a polymerase c...

journal_title：Acta haematologica

authors： Ma SK,Ma V,Chan AY,Chan LC,Chui DH

更新日期：2002-01-01 00:00:00

abstract：:A hemophilia B patient, seropositive for HIV antibodies since 1984, came to us in March 1989 with a severe necrotizing lesion of the nose. It was an erythematous lesion and looked like rhinophyma. Microbiological examination of the skin biopsy showed the presence of Cryptococcus neoformans. At the time of the study, t...

journal_title：Acta haematologica

authors： Mares M,Sartori MT,Carretta M,Bertaggia A,Girolami A

更新日期：1990-01-01 00:00:00

abstract：:Non-transfusion-dependent thalassemia (NTDT) is associated with various forms of thalassemia and genetic modifiers. We report the molecular basis of NTDT in hemoglobin (Hb) E-β-thalassemia disease. This study was done in 73 adult patients encountered at the prenatal diagnosis center of Khon Kaen University, Northeast ...

journal_title：Acta haematologica

authors： Yamsri S,Pakdee N,Fucharoen G,Sanchaisuriya K,Fucharoen S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The treatment of relapsed/refractory (R/R) peripheral T cell lymphoma (PTCL) is limited to a few agents. Romidepsin, a histone deacetylase inhibitor, was approved for PTCL treatment as a single agent in the R/R setting, yet with partial efficacy. Several attempts to combine romidepsin with other chemotherapy...

journal_title：Acta haematologica

authors： Nachmias B,Shaulov A,Lavie D,Goldschmidt N,Gural A,Saban R,Lebel E,Gatt ME

更新日期：2019-01-01 00:00:00

abstract：:In the myelodysplastic syndromes (MDS) clonogenic marrow cell culture studies have demonstrated intrinsic hemopoietic stem cell and progenitor cell abnormalities consistent with these disorders representing clonal hemopathies. Abnormal responsiveness of these cells to stimulatory and inhibitory growth factors indicate...

journal_title：Acta haematologica

authors： Greenberg PL

更新日期：1987-01-01 00:00:00

abstract：:We describe a B cell chronic lymphocytic leukemia/lymphoma (B-CLL) patient with an adrenocortical adenoma. He was treated initially with oral cyclophosphamide and prednisolone for 2 months, followed by low-dose prednisolone for an additional 2 years, which resulted in the prompt disappearance of CLL cells. After a per...

journal_title：Acta haematologica

authors： Adachi Y,Adachi M,Hinoda Y,Fukushima H,Takahashi T,Imai K

更新日期：1997-01-01 00:00:00

abstract：:Platelet functions were evaluated in 20 healthy pregnant women in the last months of pregnancy, during labor, and 5-12 weeks after labor. The results showed an increased platelet count, bleeding time and nitroblue tetrazolium (NBT) test, as well as an increased plasma calcium level postlabor. ADP- and epinephrine-indu...

journal_title：Acta haematologica

authors： Sagi A,Creter D,Goldman J,Djaldetti M

更新日期：1981-01-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) is thought to take part in the genesis of bone marrow fibrosis that can be found in patients with myeloproliferative diseases. We evaluated platelet mitogenic activity as the difference between serum and plasma activity in 8 patients with myeloproliferative disease. We observed a ...

journal_title：Acta haematologica

authors： Caenazzo A,Pietrogrande F,Polato G,Piva E,Masiero M,Sgarabotto D,Girolami A

更新日期：1989-01-01 00:00:00

abstract：:A hypercoagulable state has been described in thalassemia patients, partly due to a deficiency of inhibitors, protein C (PC) in particular. Since a potential role of a new hemostatic factor named protein Z (PZ) has been reported in hypercoagulability, we evaluated plasma PZ and PC levels in thalassemia and their possi...

journal_title：Acta haematologica

authors： Del Vecchio GC,Nigro A,Giordano P,Schettini F,Altomare M,Pietrapertosa A,De Mattia D

更新日期：2007-01-01 00:00:00

abstract：:We present the case of a woman undergoing treatment with acenocoumarol for deep vein thrombosis, who maintained an international normalized ratio (INR) of between 2.5 and 4 for 2 months. Seven days after the introduction of amoxycillin (500 mg/8 h) for a probable respiratory infection, the patient developed spontaneou...

journal_title：Acta haematologica

authors： Soto J,Sacristan JA,Alsar MJ,Fernandez-Viadero C,Verduga R

更新日期：1993-01-01 00:00:00

abstract：:A new variant of red cell glucose-6-phosphate dehydrogenase (G6PD) has been found in a Caucasian man with congenital non-spherocytic haemolytic anaemia. This variant has reduced activity, increased thermolability, increased Michaelis constants for glucose-6-phosphate and NADP, slightly increased electrophoretic mobili...

journal_title：Acta haematologica

authors： Mandelli F,Amadori S,De Laurenzi A,Kahn A,Isacchi G,Papa G

更新日期：1977-01-01 00:00:00

abstract：:Granulocytic sarcoma of the small intestine preceding or as the presenting feature of acute myelogenous leukemia with chromosome 16 abnormalities has been observed in at least 4 patients. We report the case of a patient initially diagnosed with eosinophilic gastroenteritis, responding to corticosteroid treatment for 2...

journal_title：Acta haematologica

authors： Julia A,Nomdedeu JF

更新日期：2004-01-01 00:00:00