Abstract:
:Fetal hemoglobin (HbF) concentrations were measured by a radial immunodiffusion assay in 233 patients with various malignancies. In 96 of these, alpha-fetoprotein (AFP) was also measured by radioimmunoassay. The concentration of HbF exceeded 2 SDs above the normal mean in 39 of 233 patients, most notably in patients with leukemia, lymphomas, multiple myeloma and testicular tumors. The proportion of HbF was not correlated with the total hemoglobin concentration or with serum AFP concentration.
journal_name
Acta Haematoljournal_title
Acta haematologicaauthors
Chudwin DS,Rucknagel DL,Scholnik AP,Waldmann TA,McIntire KRdoi
10.1159/000207839subject
Has Abstractpub_date
1977-01-01 00:00:00pages
288-93issue
5eissn
0001-5792issn
1421-9662journal_volume
58pub_type
杂志文章abstract::A 69-year-old man with a rare case of lymphoma-type alpha-chain disease was admitted to the hospital with marked cervical and inguinal lymph node swelling. Lymph node biopsy showed marked infiltration of plasma cells, plasmacytoid cells and immunoblastoid cells, alone or in combination. Immunoelectrophoresis and immun...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204814
更新日期:1991-01-01 00:00:00
abstract::The Philadelphia chromosome-negative myeloproliferative disorders (MPDs) polycythemia vera (PV), essential thrombocytosis (ET) and primary myelofibrosis (PMF) are characterized by increased proliferation of terminally differentiated myeloid cells. Although these disorders were recognized as clonal hematopoietic stem c...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000140634
更新日期:2008-01-01 00:00:00
abstract::Human beta-globin was produced in Escherichia coli as a cleavable fusion protein using the expression vector pLcII [Nagai and Thøgersen, Nature 301, p. 810, 1984]. The fusion protein CIIFX beta-globin was purified under denaturing conditions to homogeneity and the authentic beta-globin was liberated by blood coagulati...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205851
更新日期:1987-01-01 00:00:00
abstract::Allogeneic stem cell transplantation (SCT) is the treatment of choice for selected patients with chronic myeloid leukemia (CML). However, it is associated with a high risk of treatment-related mortality (TRM) and morbidity. To assist in decision making about transplantation, a simple scoring system to assess the risk ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000069283
更新日期:2003-01-01 00:00:00
abstract::B-cell chronic lymphocytic leukaemia (B-CLL) is characterized by a high frequency of infections, including those of viral aetiology. Previous reports have demonstrated a specific immunologic response to influenza virus vaccine in B-CLL patients with normal IgG levels. In this study, we have evaluated different immunop...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000040709
更新日期:1998-01-01 00:00:00
abstract::A family with hereditary ovalocytosis (HO) is described. The probands, 2 brothers, had splenic rupture after modest trauma as preenting symptoms. 7 members of the family had HO. The sister of the pobands had a moderately enlarged spleen. The other members proved normal on routine clinical examination. ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207420
更新日期:1980-01-01 00:00:00
abstract::The course and management of avascular necrosis of the femoral head (AVNFH) in six hips of 5 sickle cell syndrome patients (3 with Hb SS, 1 with Hb SC and 1 with Hb S/beta+-thalassaemia) are described. Two patients (aged 13 and 17 years) presented with Perthes- and osteochondritis dessicans-type lesions. These hips pr...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205873
更新日期:1987-01-01 00:00:00
abstract::The concentration of plasma vitamin B12 bound to transcobalamin II was measured by two methods: QUSO and Heparin Sepharose (HS). The new HS procedure provided a specific, direct measurement of vitamin B12 bound to both R binder and transcobalamin II in plasma. ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204522
更新日期:1993-01-01 00:00:00
abstract::Granulocytic sarcoma of the small intestine preceding or as the presenting feature of acute myelogenous leukemia with chromosome 16 abnormalities has been observed in at least 4 patients. We report the case of a patient initially diagnosed with eosinophilic gastroenteritis, responding to corticosteroid treatment for 2...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000079729
更新日期:2004-01-01 00:00:00
abstract::The first 2 Canadian cases of combinations of Hb D Los Angeles and beta-thalassaemia were found in an Italian family and an East Indian family in Hamilton, Ont. The structure of the Hb D variant was identified by radioimmunoassay. The beta +-thalassaemia trait in the Italian family and the beta o-thalassaemia trait in...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207387
更新日期:1980-01-01 00:00:00
abstract::The expression of the enzyme marker terminal deoxynucleotidyl transferase (TdT) was examined by immunofluorescence assay in the cells from 333 cases with various types and subtypes of leukemia or lymphoma. More than 90% of cALL and T-ALL, 70% of Null-ALL and 80% of pre-B-ALL were TdT-positive. One case in the commonly...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206072
更新日期:1986-01-01 00:00:00
abstract::Two unrelated patients with Bernard-Soulier syndrome and their relatives were studied. The patients demonstrated severe bleeding diathesis, the relatives were asymptomatic. The propositi showed the characteristic abnormalities of the syndrome: thrombocytopenia, a percentage of giant platelets higher than 65%, prolonge...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206125
更新日期:1986-01-01 00:00:00
abstract::In the chronic wound, the normal cascade of inflammation, granulation and reconstruction phases of healing is interrupted. Cytokines are now known to orchestrate different biochemical mediators resulting in the restoration of the healing phases. Growth factors may play a significant role in stimulating wound repair by...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000040833
更新日期:1998-01-01 00:00:00
abstract::A case of steroid-resistant acquired pure red-cell aplasia associated with a relative and absolute increase of TG cells is described. Removal of T cells enhanced erythroid colony and burst formation in vitro, and it is suggested that TG cells may be implicated in the pathogenesis of this case of acquired pure red-cell...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207191
更新日期:1981-01-01 00:00:00
abstract::Coagulation factor VIII inhibitor arising in a patient with autoimmune disease was immunologically analyzed. A 63-year-old man who had been diagnosed as suffering from polyarteritis nodosa was treated with prednisolone for 10 years. Severe bleeding tendency developed and coagulation studies demonstrated a high titer o...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204879
更新日期:1991-01-01 00:00:00
abstract::A 13-year-old Saudi girl presented with severe clinical features of systemic lupus erythematosus of 3 months' duration. In addition to laboratory evidence of the disease, the patient was found to have pancytopenia and myelofibrosis. While pancytopenia was considerably improved by steroids, myelofibrosis was not revers...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205641
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To investigate a family with factor VII (FVII) deficiency from Argentina. PATIENTS AND METHODS:The proposita is a 14-year-old girl who presented with a mild to moderate bleeding tendency. Menorrhagia is controlled with periodical administration of small doses of recombinant FVII concentrate. The mother of th...
journal_title:Acta haematologica
pub_type:
doi:10.1159/000507071
更新日期:2021-01-01 00:00:00
abstract::The detection of cellular antigens in bone marrow sections depends on the method of embedding, the nature of antigen and antibody, antigen retrieval techniques and the sensitivity of the immunohistochemical method. This study evaluated a fluorescyl-tyramide-enhanced immunostaining method on methyl-methacrylate-embedde...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000097458
更新日期:2007-01-01 00:00:00
abstract::Chromosomal aberrations in a case of atypic myeloproliferative syndrome are reported. The analysis was carried out on short-term cultures of sternal bone marrow with the ASG and fluorescence method. 90% of the metaphases studied showed pseudoliploidy: one of the chromosomes 12 was missing and one submedian marker chro...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000208052
更新日期:1975-01-01 00:00:00
abstract::Factor VII deficiency is the least rare among uncommon congenital coagulation disorders. The majority of cases are isolated deficiencies. In some cases, FVII deficiency has been found to be associated with the deficiency in another coagulation factor or with non-coagulation-related abnormalities or defects. The evalua...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000096789
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:In 2003, oral fludarabine was introduced in the USA for the treatment of patients with hematologic malignancies as an alternative to its intravenous (i.v.) formulation; in 2008, it was introduced in México while the i.v. formulation was withdrawn. Accordingly, i.v. fludarabine had to be replaced by oral flud...
journal_title:Acta haematologica
pub_type: 临床试验,杂志文章
doi:10.1159/000357108
更新日期:2014-01-01 00:00:00
abstract::Analysis of donor chimerism has become a routine method for the documentation of engraftment after allogeneic hematopoietic stem cell transplantation (HSCT). In recent years several groups have also focused on the application of this technique for the detection of relapsing disease after allogeneic HSCT. This review a...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000077555
更新日期:2004-01-01 00:00:00
abstract::Aspirates from bone marrow, spleen and liver were morphologically analysed in 15 untreated patients wich chronic myeloid leukaemia. Megaloblastic changes of the erythroblasts were found to be more common in the spleen and liver than in the bone marrow. A significant increase of 'erythroblastic islands', i.e. erythrobl...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000208026
更新日期:1976-01-01 00:00:00
abstract::We report a patient with lung cancer who developed CD56-positive acute lymphoblastic leukemia. He was referred to our hospital for thrombocytopenia. Atypical cells were found in the blood and the bone marrow. These cells were immunophenotypically positive for CD3epsilon, CD56, and terminal deoxynucleotidyl transferase...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000087891
更新日期:2005-01-01 00:00:00
abstract::Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative myeloproliferative neoplasms. Preclinical results support that JAK2 inhibitors could show efficacy in treating chronic myeloproliferative neopla...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000356784
更新日期:2014-01-01 00:00:00
abstract::Contamination of autologous graft by tumor, in addition to incomplete tumor eradication, can partly explain why relapse remains the commonest cause of treatment failure after autologous stem cell transplantation (ASCT) in patients with malignant hematologic disorders. Monitoring of minimal residual disease (MRD) is no...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000088411
更新日期:2005-01-01 00:00:00
abstract::Chronic graft-versus-host disease (GVHD) is a severe complication of allogeneic stem cell transplantation, with a substantial impact on the quality of life and survival, still lacking with regard to an optimal therapeutic strategy. Corticosteroids are considered the standard of care for first-line treatment of chronic...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000345836
更新日期:2013-01-01 00:00:00
abstract::Bone marrow fragments from 10 patients with a megaloblastic anaemia due to vitamin B12 or folate deficiency were studied by electron microscopy and electron microscope autoradiography. A proportion of the erythroblasts showed ultrastructural abnormalities. Some of the cells containing autophagic vacuoles, large sidero...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207854
更新日期:1977-01-01 00:00:00
abstract::A rare case of Hodgkin's disease which initially presented with a thyroid tumor in an 18-year-old-man is reported. The tumor involved most of the thyroid gland but was well demarcated, and the border between the tumor and the remnants of the thyroid gland was relatively clear, suggesting secondary Hodgkin's disease in...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000203627
更新日期:1997-01-01 00:00:00
abstract::A 27-year-old male developed massive generalized lymphadenopathy with chronic myelomonocytic leukemia (CMML) presenting as extramedullary blast crisis mimicking a lymphocytic lymphoma. On presentation, a consistent chromosomal abnormality involving chromosomes 8 and 13, i.e. 46,XY,t(8;13) (q11;p11), was present in lym...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204687
更新日期:1992-01-01 00:00:00