CD56-positive acute lymphoblastic leukemia.

Abstract:

:We report a patient with lung cancer who developed CD56-positive acute lymphoblastic leukemia. He was referred to our hospital for thrombocytopenia. Atypical cells were found in the blood and the bone marrow. These cells were immunophenotypically positive for CD3epsilon, CD56, and terminal deoxynucleotidyl transferase, and negative for surface CD3, CD4, CD19, CD33, and myeloperoxidase. A small proportion of leukemic cells express CD13. There were no rearrangements of T-cell receptor (TCR)-beta, TCR-gamma, or immunoglobulin heavy chain. No Epstein-Barr virus was detected. Systemic examination did not detect any tumors other than pulmonary adenocarcinoma, and the patient was diagnosed as having acute natural killer (NK) cell leukemia. Chemotherapy was effective, and he achieved complete remission. The course of the disease was complicated by a lung abscess, and the patient died 3 months after the diagnosis. We considered that the diagnosis was blastic NK cell lymphoma/leukemia subtype. However, it actually was myeloid/NK cell precursor leukemia subtype that weakly expressed CD13.

journal_name

Acta Haematol

journal_title

Acta haematologica

authors

Matano S,Terahata S,Nakamura S,Kobayashi K,Sugimoto T

doi

10.1159/000087891

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

160-3

issue

3

eissn

0001-5792

issn

1421-9662

pii

87891

journal_volume

114

pub_type

杂志文章
  • Serum sickness from iron-dextran administration.

    abstract::Hypersensitivity vasculitis occurs in response to various exogenous agents. A case of a serum sickness syndrome with cutaneous vasculitis is described in a patient given an intravenous iron-dextran infusion. ...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000205198

    authors: Bielory L

    更新日期:1990-01-01 00:00:00

  • Strategies and clinical implications of chimerism diagnostics after allogeneic hematopoietic stem cell transplantation.

    abstract::Analysis of donor chimerism has become a routine method for the documentation of engraftment after allogeneic hematopoietic stem cell transplantation (HSCT). In recent years several groups have also focused on the application of this technique for the detection of relapsing disease after allogeneic HSCT. This review a...

    journal_title:Acta haematologica

    pub_type: 杂志文章,评审

    doi:10.1159/000077555

    authors: Thiede C,Bornhäuser M,Ehninger G

    更新日期:2004-01-01 00:00:00

  • Congenital afibrinogenaemia in a Saudi family: a case report and family study.

    abstract::Afibrinogenaemia in a female Saudi child is reported. Two siblings died of bleeding. The parents, who are first cousins, a brother and two sisters are asymptomatic heterozygotes with fibrinogen levels of less than 1.5 g/l. The presentation was described and compared to other cases reported. ...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000206624

    authors: Elseed FA,Karrar ZA

    更新日期:1984-01-01 00:00:00

  • An Eltrombopag Red (Plasma) Alert.

    abstract::Eltrombopag is a thrombopoietin receptor agonist frequently used to manage immune thrombocytopenia and aplastic anemia. At the high doses used for aplastic anemia, but not the doses used for immune thrombocytopenia, eltrombopag can cause reddish-brown discoloration of plasma, which can interfere with bilirubin measure...

    journal_title:Acta haematologica

    pub_type:

    doi:10.1159/000508599

    authors: Al-Samkari H,Goodarzi K

    更新日期:2020-07-22 00:00:00

  • Gene therapy targeting hematopoietic cells: better not leave it to chance.

    abstract::Gene therapy targeting hematopoietic cells has arrived at a new stage of potency. While the potential for curing inherited disorders of the immune system has been demonstrated in clinical trials, we were also confronted with the first serious adverse events related to random insertion of foreign DNA into cellular chro...

    journal_title:Acta haematologica

    pub_type: 杂志文章,评审

    doi:10.1159/000072459

    authors: Baum C,von Kalle C

    更新日期:2003-01-01 00:00:00

  • Definition of CD 11a, b, c, and CD 18 glycoproteins on chemotactically deficient granulocyte membranes in patients affected by myeloid disorders.

    abstract::We studied neutrophil chemotaxis and surface membrane glycoproteins in 12 patients suffering from myeloid disorders with abnormal karyotype using in vitro techniques in all 12. Chromosome studies were also carried out virtually simultaneously. We chose to study only patients showing a deficit of chemotaxis (p less tha...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000205543

    authors: Ricevuti G,Mazzone A,Notario A

    更新日期:1989-01-01 00:00:00

  • Human urinary erythropoietin: preparation with high potency.

    abstract::Human urinary erythropoietin has been purified to homogeneity. The seven-step procedure yielded a preparation with a potency of 225,000 U/mg protein. SDS-polyacrylamide gel electrophoretic analysis of the purified hormone revealed a single protein band with a molecular weight of about 35,000 that migrated with the bio...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000205057

    authors: Matsushita J,Kawakita M,Shibuya K,Koishihara Y,Sakaguchi M,Takatsuki A

    更新日期:1990-01-01 00:00:00

  • Plasma protein Z and protein C inhibitors and their role in hypercoagulability of thalassemia.

    abstract::A hypercoagulable state has been described in thalassemia patients, partly due to a deficiency of inhibitors, protein C (PC) in particular. Since a potential role of a new hemostatic factor named protein Z (PZ) has been reported in hypercoagulability, we evaluated plasma PZ and PC levels in thalassemia and their possi...

    journal_title:Acta haematologica

    pub_type: 临床试验,杂志文章

    doi:10.1159/000107924

    authors: Del Vecchio GC,Nigro A,Giordano P,Schettini F,Altomare M,Pietrapertosa A,De Mattia D

    更新日期:2007-01-01 00:00:00

  • Treatment of iron deficiency anemia with intravenous iron preparations.

    abstract:OBJECTIVE:We aimed to determine the effects of intravenous iron therapy on blood parameters in pediatric patients who do not tolerate oral iron therapy for any reason. PATIENTS AND METHODS:The patient group consisted of candidates for elective operations requiring blood transfusions in order to raise hemoglobin (Hb) c...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000092348

    authors: Akarsu S,Taskin E,Yilmaz E,Yilmaz H,Kilic M,Aygun AD

    更新日期:2006-01-01 00:00:00

  • Hemophilic arthropathy complicated by polyarticular septic arthritis.

    abstract::A case of multiple pyarthroses due to Staphylococcus aureus occurring in a severe classical hemophiliac is presented. Successful management depended on drainage of the infected joints and a prolonged course of antibiotics. Several criteria are suggested for recognition of hemophiliacs who might benefit from joint aspi...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000206569

    authors: Goldsmith JC,Silberstein PT,Fromm RE Jr,Walker DY

    更新日期:1984-01-01 00:00:00

  • Aplastic anemia: assessment of myeloid progenitor cells in the bone marrow and blood provides prognostic information.

    abstract::15 patients with aplastic anemia were prospectively followed after having measurements of myeloid progenitor cells in bone marrow and blood. Treatment included androgens, low or high dose steroids and standardized supportive care. The median length of survival was 5.8 months. When patients were grouped according to th...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000206263

    authors: Hinterberger W,Geissler K,Fischer M,Lechner K,Kabrna E

    更新日期:1985-01-01 00:00:00

  • Correlation between preferentially expressed antigen of melanoma and tumour necrosis factor-related apoptosis-inducing ligand gene expression in different types of leukaemia patients.

    abstract:INTRODUCTION:Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) down-regulation by preferentially expressed antigen of melanoma (PRAME) is a general phenomenon in different types of solid tumours, but research on the correlation between PRAME and TRAIL gene expression in leukaemia patients is rare. METHO...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000351166

    authors: Zhang W,Chi K,Zhang Y,Ma B,Shi J,Chen Y,Lei P,Li Y,Sun K

    更新日期:2013-01-01 00:00:00

  • Clinical Management of Posterior Reversible Encephalopathy Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation: A Case Series and Review of the Literature.

    abstract:BACKGROUND:Posterior reversible encephalopathy syndrome (PRES) is a rare but serious complication after allogeneic hematopoietic stem cell transplantation (alloHSCT). Among others, calcineurin inhibitors (CNI) for prophylaxis of graft-versus-host disease (GvHD) may promote the development of PRES, but the pathomechanis...

    journal_title:Acta haematologica

    pub_type: 杂志文章,评审

    doi:10.1159/000430489

    authors: Schmidt V,Prell T,Treschl A,Klink A,Hochhaus A,Sayer HG

    更新日期:2016-01-01 00:00:00

  • In vivo models of thrombogenic potential: usefulness and limitations.

    abstract::The thrombogenicity of prothrombin complex concentrates (PCCs) has been known as a risk factor since their first clinical use about 30 years ago. The development of in vivo models to define the thrombogenic components in PCCs was instrumental in providing a logical basis for selecting in vitro assays to screen for the...

    journal_title:Acta haematologica

    pub_type: 杂志文章,评审

    doi:10.1159/000204039

    authors: MacGregor I,McLaughlin L,Drummond O,Prowse C,Ferguson J

    更新日期:1995-01-01 00:00:00

  • Central nervous system expression of a monoclonal paraprotein in a chronic lymphocytic leukemia patient.

    abstract::An unusual complication of chronic lymphocytic leukemia (CLL) is reported. The patient, a 79-year-old man, had a long standing history of CLL, that had been complicated by the development of a Guillain-Barré-like syndrome and a peripheral biclonal gammopathy. The biclonal immunoglobulins identified in the serum were I...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000204593

    authors: Ruiz P,Moezzi M,Chamizo W,Ganjei P,Whitcomb CC,Rey LC

    更新日期:1992-01-01 00:00:00

  • Variations in morphological and immunological blast cell phenotype in a case of acute leukaemia with t(4;11) translocation.

    abstract::A case of acute leukaemia with t(4;11) chromosomal abnormality in a 28-year-old woman is reported. At diagnosis, two blast cell populations were seen: 60% of the cells were small cells with lymphoid morphology, 40% were large cells with monocytic morphology. Cytochemical examination was consistent with acute myeloid l...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000206046

    authors: Campos L,Espinouse D,Felman P,Charrin C,Gentilhomme O,Germain D

    更新日期:1986-01-01 00:00:00

  • Haemoglobin D Los Angeles, D-beta +-thalassaemia, and D-beta o-thalassaemia. A report of two Canadian families.

    abstract::The first 2 Canadian cases of combinations of Hb D Los Angeles and beta-thalassaemia were found in an Italian family and an East Indian family in Hamilton, Ont. The structure of the Hb D variant was identified by radioimmunoassay. The beta +-thalassaemia trait in the Italian family and the beta o-thalassaemia trait in...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000207387

    authors: Wong SC,Ali MA

    更新日期:1980-01-01 00:00:00

  • Evidence for an erythropoietin-stimulating factor in patients with renal and hepatic disease.

    abstract::Recently, a factor was discovered in the serum of hepatectomized animals which was capable of augmenting the hepatic erythropoietin response to hypoxia when injected into normal rats. This substance was localized in the liver via an in situ perfusion technique and was termed the hepatic erythropoietic factor (HEF). Pa...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000206884

    authors: Naughton BA,Liu P,Naughton GK,Gordon AS

    更新日期:1983-01-01 00:00:00

  • Aspergillus vegetative endocarditis complicated with schizocytic hemolytic anemia in a patient with acute lymphocytic leukemia.

    abstract::Aspergillus vegetative endocarditis developing in a patient with acute lymphocytic leukemia during the phase of hematological remission has led to a fatal outcome, complicated with severe hemolytic anemia with red cell fragmentation. Systemic aspergillosis may involve heart valves with underlying disorders, but seldom...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000206021

    authors: Nishiura T,Miyazaki Y,Oritani K,Tominaga N,Tomiyama Y,Katagiri S,Kanayama Y,Yonezawa T,Tarui S,Yamada T

    更新日期:1986-01-01 00:00:00

  • Deformability of the erythrocyte membrane in patients with myelodysplastic syndromes.

    abstract::One of the major determinants of erythrocyte survival is membrane deformability, and an important intrinsic parameter of membrane deformability is the shear elastic modulus (mu) with higher mu values corresponding to increased membrane rigidity. Using a micropipette technique, we determined the shear elastic modulus o...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000204753

    authors: Athanassiou G,Symeonidis A,Kourakli A,Missirlis YF,Zoumbos NC

    更新日期:1992-01-01 00:00:00

  • Impairment of platelet adhesiveness and platelet factor 3 activity in cyanotic congenital heart disease.

    abstract::In 33 children with cyanotic congenital heart disease the platelet function has been studied. The most significant changes were reduced platelet adhesiveness to glass and impaired availability of platelet factor 3 in nearly 50% of the patients. Although clot retraction was poor in 84% of them, thrombocytopenia and pro...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000208017

    authors: Bhargava M,Sanyal SK,Thapar MK,Kumar S,Hooja V

    更新日期:1976-01-01 00:00:00

  • Incidence of TdT positivity in cases of leukemia and lymphoma.

    abstract::The expression of the enzyme marker terminal deoxynucleotidyl transferase (TdT) was examined by immunofluorescence assay in the cells from 333 cases with various types and subtypes of leukemia or lymphoma. More than 90% of cALL and T-ALL, 70% of Null-ALL and 80% of pre-B-ALL were TdT-positive. One case in the commonly...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000206072

    authors: Drexler HG,Menon M,Minowada J

    更新日期:1986-01-01 00:00:00

  • Acute promyelocytic leukemia in childhood. Report of a case with a review of the literature.

    abstract::A rare case of acute promyelcytic leukemia (APL) is reported in a 7-year-old boy. The patient displayed the typical features of APL including impaction of the marrow with promyelocytes, marked elevation of the serum vitamin B12 and transcobalamin I levels and a hemorrhagic diathesis. The bleeding diathesis in the case...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000207589

    authors: Engelhard D,Yatziv S,Rachmilewitz EA,Polliack A

    更新日期:1979-01-01 00:00:00

  • Chemotherapeutic remissions in Wistar Furth rat acute myelogenous leukemia: a model for human AML.

    abstract::Acute myelogenous leukemia (AML) of the inbred Wistar/Furth (W/Fu) rat is pathophysiologically similar to human AML. Subcutaneous transplantation of 1.0 X 10(6) cells of a clonal tissue culture line of W/Fu AML into 6- to 8-week-old rats produced local myeloblastomas in 8--10 days which progressed to infiltration of r...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000207886

    authors: Greenberger JS,Bocaccino CA,Szot SJ,Moloney WC

    更新日期:1977-03-01 00:00:00

  • Two cases of ampulla (takotsubo-shaped) cardiomyopathy associated with hemophagocytic lymphohistiocytosis.

    abstract::There have been many reports of patients with ampulla cardiomyopathy described as takotsubo-shaped cardiomyopathy in the cardiovascular field. This unique cardiomyopathy is characterized by transient apical ballooning and hypokinesis of the left ventricle. We describe 2 cases of ampulla cardiomyopathy associated with ...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000098461

    authors: Takeoka Y,Nakamae M,Nakamae H,Hagihara K,Sakamoto E,Nakane T,Koh H,Koh KR,Ohta K,Yamane T,Hino M

    更新日期:2007-01-01 00:00:00

  • Acute graft-versus-host disease resulting from normal donor blood transfusions.

    abstract::2 fatal cases of graft-versus-host disease (GvHD) occurred following blood product transfusions given to patients receiving standard chemotherapy for Hodgkin's disease. GvHD was established by HLA typing, clinical course, and compatible skin biopsy. 23 cases of GvHD following transfusion of blood products from normal ...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000206599

    authors: Burns LJ,Westberg MW,Burns CP,Klassen LW,Goeken NE,Ray TL,Macfarlane DE

    更新日期:1984-01-01 00:00:00

  • Analysis of Efficacy and Prognostic Factors of CLAG Treatment in Chinese Patients with Refractory or Relapsed Acute Myeloid Leukemia.

    abstract:BACKGROUND/AIMS:The aim of this work was to investigate the efficacy and predictive factors of CLAG treatment in refractory or relapsed (R/R) acute myeloid leukemia (AML) patients. METHODS:Sixty-seven R/R AML patients were enrolled in this prospective cohort study and treated by a CLAG regimen: 5 mg/m2/day cladribine ...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000493250

    authors: Wang L,Xu J,Tian X,Lv T,Yuan G

    更新日期:2019-01-01 00:00:00

  • Serum ferritin levels in thalassemias and the effect of splenectomy.

    abstract::Iron overload is a constant and the more important complication in thalassemia. Serum ferritin concentration accurately reflects body iron stores. A total of 245 thalassemic patients aged 12-55 years were examined, 71 having Hb H disease and 174 beta-thalassemia/Hb E disease. The patients received minimal or no blood ...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000207129

    authors: Pootrakul P,Vongsmasa V,La-ongpanich P,Wasi P

    更新日期:1981-01-01 00:00:00

  • Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia.

    abstract::At diagnosis, clonal gene rearrangement probes [retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3)] were detected in bone marrow samples from 71 of 153 patients with acu...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000041035

    authors: Schmetzer HM,Braun S,Wiesner D,Duell T,Gerhartz HH,Mittermueller J

    更新日期:2000-01-01 00:00:00

  • Hodgkin lymphoma accompanied by aplastic anemia and polyclonal expansion of large granular lymphocytes.

    abstract::Immunologic abnormalities have been described in patients with Hodgkin lymphoma, including autoimmune hemolytic anemia and immune thrombocytopenic purpura. The concurrent diagnoses of Hodgkin lymphoma and acquired aplastic anemia, however, is extremely rare. We report a 56-year-old Japanese female patient with severe ...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000100038

    authors: Saitoh T,Matsushima T,Yamane A,Sakuraya M,Irisawa H,Yokohama A,Handa H,Tsukamoto N,Karasawa M,Nojima Y,Murakami H

    更新日期:2007-01-01 00:00:00