Aplastic anemia: assessment of myeloid progenitor cells in the bone marrow and blood provides prognostic information.

abstract：:Agranulocytosis developed in a 20-year-old Greek patient with beta-thalassaemia major, 11 weeks after commencing chelation with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) and 6 weeks after receiving the drug at a total daily dose of 105 mg/kg. The patient presented with generalised weakness, low-gra...

journal_title：Acta haematologica

authors： al-Refaie FN,Veys PA,Wilkes S,Wonke B,Hoffbrand AV

更新日期：1993-01-01 00:00:00

abstract：:In a retrospective study of 38 patients with histologically proven myelofibrosis, 5 parameters (recorded on the first admission) were investigated as to their usefulness to predict the course of the disease. In 9 patients the development of 'acute' myelofibrosis could be predicted by the finding of pancytopenia, low r...

journal_title：Acta haematologica

authors： Rojer RA,Mulder NH,Nieweg HO

更新日期：1978-01-01 00:00:00

abstract：:A case of acquired haemophilia A presenting with extensive spontaneous bruising and anaemia is reported. The anaemia was due to myelodysplastic syndrome (FAB: refractory anaemia with ringed sideroblasts). A factor-VII:C-specific inhibitor was also found. Prednisone and pyridoxine were given, and the inhibitor became u...

journal_title：Acta haematologica

authors： Lin CK,Liang R,Liu HW,Tse PW,Chan GT

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Argininemia is an autosomal recessive urea cycle disorder (UCD). Unlike other UCD, hyperammonemia is rarely seen. Patients usually present in childhood with neurological symptoms. Uncommon presentations like neonatal cholestasis or cirrhosis have been reported. Although transient elevations of liver transami...

journal_title：Acta haematologica

authors： Kiykim E,Zubarioglu T,Cansever MS,Celkan T,Häberle J,Aktuglu Zeybek AC

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:Autophagy is crucial for the survival and function of plasma cells including protection from toxic misfolded immunoglobulin and proper energy metabolism. Multiple myeloma (MM) is an indolent but eventually fatal neoplasm of plasma cells. Autophagy may play a critical role in the survival of MM cells and...

journal_title：Acta haematologica

authors： Jung G,Roh J,Lee H,Gil M,Yoon DH,Suh C,Jang S,Park CJ,Huh J,Park CS

更新日期：2015-01-01 00:00:00

abstract：:It has been proposed that iron overload may adversely affect liver disease outcome. The recent identification of 2 mutations in the HFE gene related to hereditary haemochromatosis (Cys282Tyr and His63Asp) provided an opportunity to test whether they are associated with hepatic iron accumulation and the activity and se...

journal_title：Acta haematologica

authors： Martinelli AL,Franco RF,Villanova MG,Figueiredo JF,Secaf M,Tavella MH,Ramalho LN,Zucoloto S,Zago MA

更新日期：2000-01-01 00:00:00

abstract：:Tumor cell (TC) contamination of stem cell products can contribute to relapse after high dose chemotherapy and stem cell rescue. A new purging technology using replication-deficient recombinant adenovirus (Adv) containing the p53 tumor suppressor gene (Adv-p53) has been suggested to reduce tumor contamination of autol...

journal_title：Acta haematologica

authors： Hirai M,Kelsey LS,Maneval DC,Vaillancourt M,Talmadge JE

更新日期：1999-01-01 00:00:00

abstract：:A family with hereditary ovalocytosis (HO) is described. The probands, 2 brothers, had splenic rupture after modest trauma as preenting symptoms. 7 members of the family had HO. The sister of the pobands had a moderately enlarged spleen. The other members proved normal on routine clinical examination. ...

journal_title：Acta haematologica

authors： Kjellman B,Larsson C,Tibblin E

更新日期：1980-01-01 00:00:00

abstract：:The increased incidence of parallel tubular structures in lymphocytes of patients with Hodgkin's disease was investigated for a correlation with either impairment of cellular immunity (measured by DNCB-skin test and PHA-induced lymphocyte stimulation in vitro) or an increase of antibodies against cytomegalovirus or Ep...

journal_title：Acta haematologica

authors： Halie MR,Langenhuysen MM,de Gast GC,Nieweg HO

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Not all patients with diffuse large B-cell lymphoma (DLBCL) are candidates for aggressive regimens. (90)Y ibritumomab tiuxetan ((90)Y-IT), an anti-CD20 radionuclide-conjugated antibody, has demonstrated clinical efficacy in DLBCL with a favorable toxicity profile. METHODS:This phase II trial investigated th...

journal_title：Acta haematologica

authors： Arnason JE,Luptakova K,Rosenblatt J,Tzachanis D,Avigan D,Zwicker JI,Levine J,Kim M,Parker JA,Grant B,Joyce RM

更新日期：2015-01-01 00:00:00

abstract：:Thalidomide acts on the microenvironment of myelodysplastic syndromes (MDS) by influencing cytokine networks, and growing evidence supports thalidomide's usefulness in the management of haematological malignancies, such as MDS. The European Collaboration Group on Myelofibrosis with Myeloid Metaplasia reviewed patients...

journal_title：Acta haematologica

authors： Prentice HG,Sacchi S,Russell N

更新日期：2005-01-01 00:00:00

abstract：:We report a patient with lung cancer who developed CD56-positive acute lymphoblastic leukemia. He was referred to our hospital for thrombocytopenia. Atypical cells were found in the blood and the bone marrow. These cells were immunophenotypically positive for CD3epsilon, CD56, and terminal deoxynucleotidyl transferase...

journal_title：Acta haematologica

authors： Matano S,Terahata S,Nakamura S,Kobayashi K,Sugimoto T

更新日期：2005-01-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an interferon (IFN)-induced molecule with apoptotic activity. We examined gene mutations in the death domains of TRAIL receptor 1 (TRAIL-R1) and TRAIL receptor 2 (TRAIL-R2), and in the TRAIL gene promoter in 46 chronic myelogenous leukemia (CML) patien...

journal_title：Acta haematologica

authors： Liu LG,Tanaka H,Ito K,Ito T,Sultana TA,Kyo T,Kimura A

更新日期：2005-01-01 00:00:00

abstract：:In cutaneous T-cell lymphomas (CTCL; mycosis fungoides and Sézary syndrome), the standard therapies tend to be effective but not curative. Single drug therapy with either interferon-alpha or retinoids shows a response rate of about 45%. In this article, we report the results obtained in the treatment of CTCL with a co...

journal_title：Acta haematologica

authors： Dreno B,Celerier P,Litoux P

更新日期：1993-01-01 00:00:00

abstract：:Chromosomal aberrations in a case of atypic myeloproliferative syndrome are reported. The analysis was carried out on short-term cultures of sternal bone marrow with the ASG and fluorescence method. 90% of the metaphases studied showed pseudoliploidy: one of the chromosomes 12 was missing and one submedian marker chro...

journal_title：Acta haematologica

authors： Fleischmann T,Krizsa F

更新日期：1975-01-01 00:00:00

abstract：:Significant DNA polymorphisms have been reported in the beta-globin gene cluster of epsilon-G gamma-A gamma-psi beta-delta-beta-gene region, in normal (Hb AA) individuals and in patients with sickle cell anaemia (SCA). Investigations of the extent of the DNA polymorphisms in the beta A- and beta S-globin gene cluster ...

journal_title：Acta haematologica

authors： el-Hazmi MA,Bahakim HM,Warsy AS

更新日期：1992-01-01 00:00:00

abstract：:The maturation process of leukemic myelomonocytoid cells derived from peripheral blood of two typical cases of chronic myelomonocytic leukemia was investigated in vitro. In both cases, liquid culture of the leukemic cells in the presence or absence of 12-o-tetradecanoyl phorbol-13-acetate yielded either monocyte-macro...

journal_title：Acta haematologica

authors： Takuwa N,Kanegasaki S,Asano S,Tomita T,Nakayama E,Sato N,Shinohara T,Miwa S

更新日期：1984-01-01 00:00:00

abstract：:Factor VIII (FVIII) inhibitor antibodies are produced against functional epitopes of FVIII in about 30% of severe hemophilia A patients leading to inhibition of its procoagulant activity. The Bethesda assay, the most commonly used method to measure FVIII inhibitors, based on inhibition of coagulant activity of FVIII, ...

journal_title：Acta haematologica

authors： Towfighi F,Gharagozlou S,Sharifian RA,Kazemnejad A,Esmailzadeh K,Managhchi MR,Shokri F

更新日期：2005-01-01 00:00:00

abstract：:At diagnosis, clonal gene rearrangement probes [retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3)] were detected in bone marrow samples from 71 of 153 patients with acu...

journal_title：Acta haematologica

authors： Schmetzer HM,Braun S,Wiesner D,Duell T,Gerhartz HH,Mittermueller J

更新日期：2000-01-01 00:00:00

abstract：:In the myelodysplastic syndromes (MDS) clonogenic marrow cell culture studies have demonstrated intrinsic hemopoietic stem cell and progenitor cell abnormalities consistent with these disorders representing clonal hemopathies. Abnormal responsiveness of these cells to stimulatory and inhibitory growth factors indicate...

journal_title：Acta haematologica

authors： Greenberg PL

更新日期：1987-01-01 00:00:00

abstract：:Patients with sickle cell disease have an increased tendency to develop frequent and severe pyogenic infections. Lymphocyte subpopulations were studied in 14 patients with homozygous sickle cell anaemia (SCA) using the OKT monoclonal antibody. The mean absolute lymphocyte counts observed in patients with SCA were simi...

journal_title：Acta haematologica

authors： Adedeji MO

更新日期：1985-01-01 00:00:00

abstract：:Cardiac scintigraphy has been performed in 60 beta-thalassaemia major patients aged 8-35 years who received regular blood transfusions and subcutaneous desferrioxamine (DFX) chelation. Fifty-seven showed no clinical, radiological or electrocardiographic evidence of heart disease and 3 had clinically apparent cardiac f...

journal_title：Acta haematologica

authors： Aldouri MA,Wonke B,Hoffbrand AV,Flynn DM,Ward SE,Agnew JE,Hilson AJ

更新日期：1990-01-01 00:00:00

abstract：:There have been many reports of patients with ampulla cardiomyopathy described as takotsubo-shaped cardiomyopathy in the cardiovascular field. This unique cardiomyopathy is characterized by transient apical ballooning and hypokinesis of the left ventricle. We describe 2 cases of ampulla cardiomyopathy associated with ...

journal_title：Acta haematologica

authors： Takeoka Y,Nakamae M,Nakamae H,Hagihara K,Sakamoto E,Nakane T,Koh H,Koh KR,Ohta K,Yamane T,Hino M

更新日期：2007-01-01 00:00:00

abstract：:The thrombogenicity of prothrombin complex concentrates (PCCs) has been known as a risk factor since their first clinical use about 30 years ago. The development of in vivo models to define the thrombogenic components in PCCs was instrumental in providing a logical basis for selecting in vitro assays to screen for the...

journal_title：Acta haematologica

authors： MacGregor I,McLaughlin L,Drummond O,Prowse C,Ferguson J

更新日期：1995-01-01 00:00:00

abstract：:A case of steroid-resistant acquired pure red-cell aplasia associated with a relative and absolute increase of TG cells is described. Removal of T cells enhanced erythroid colony and burst formation in vitro, and it is suggested that TG cells may be implicated in the pathogenesis of this case of acquired pure red-cell...

journal_title：Acta haematologica

authors： Linch DC,Cawley JC,MacDonald SM,Masters G,Roberts BE,Antonis AH,Waters AK,Sieff C,Lydyard PM

更新日期：1981-01-01 00:00:00

abstract：:The distribution of thymus-dependent (T cells) and bone marrow-derived lymphocytes (B cells) was studied in 74 patients with Hodgkin's disease and 33 normal controls. A T cell deficit was found in untreated patients as well as in long-term survivors in remission. Therapy slightly enhanced the T cell depletion in Hodgk...

journal_title：Acta haematologica

authors： Many A,Biniaminov M,Rosenthal E,Aghai E,Ramot B

更新日期：1976-01-01 00:00:00

abstract：:A 69-year-old man with a rare case of lymphoma-type alpha-chain disease was admitted to the hospital with marked cervical and inguinal lymph node swelling. Lymph node biopsy showed marked infiltration of plasma cells, plasmacytoid cells and immunoblastoid cells, alone or in combination. Immunoelectrophoresis and immun...

journal_title：Acta haematologica

authors： Itoh Y,Ohtaki H,Ono T,Mori N,Kawaoi A,Kawai T

更新日期：1991-01-01 00:00:00

abstract：:In a 42-year-old Caucasian female, acute myelocytic leukemia (M2) presented as occlusion of the distal aorta and right iliac artery. She died after 10 days of respiratory failure. At postmortem examination the aortic wall contained multiple thrombi composed of fibrin and leukemic cells. There was no evidence of diffus...

journal_title：Acta haematologica

authors： Kootte AM,Thompson J,Bruijn JA

更新日期：1986-01-01 00:00:00

abstract：:Platelet to leukocyte adhesion phenomena (PLAP) and the phagocytosis of platelets by neutrophils from the EDTA anticoagulated blood samples are described. PLAP was transferable to a normal blood specimen by patient's plasma or serum with or without complement. Further studies revealed in vitro evidence of hereditary p...

journal_title：Acta haematologica

authors： Yoo D,Weems H,Lessin LS

更新日期：1982-01-01 00:00:00

abstract：:Granulocytic sarcoma (GS) is a rare extramedullary tumor composed of immature myeloid cells. It is usually associated with leukemia or other myeloproliferative disorders, but can also occur without overt hematologic disease, i.e. in patients with a normal bone marrow and no history of acute myelogenous leukemia. This ...

journal_title：Acta haematologica

authors： Breccia M,Petti MC,Fraternali-Orcioni G,Monarca B,Latagliata R,D'Elia GM,Mandelli F,Pileri SA

更新日期：2000-01-01 00:00:00