Thrombotic thrombocytopenic purpura associated with transient chromosomal aberrations: successful treatment with plasma exchange.

abstract：:It has been found possible to test ferritin concentrations in the reticulum and hemopoietic cells from human bone marrow by an immunoradiometric assay. Ferritin concentration in healthy test persons amounts to 0.92 +/- 0.38 ng/microgram protein in the reticulum and 0.084 +/- 0.031 ng/microgram protein in hemopoietic c...

journal_title：Acta haematologica

authors： Oertel J,Stephan M,Kastner M

更新日期：1982-01-01 00:00:00

abstract：:The adaptation of cell physiological parameters of erythrocytes of the newborn to erythrocytes in later life was studied by cell separation in an isopycnic dextran density gradient. The cell characteristics during the first trimester of life were followed by repeated determinations. The mean cellular haemoglobin conce...

journal_title：Acta haematologica

authors： Grauel EL,Müller S,Gross J,Syllm-Rapoport I

更新日期：1982-01-01 00:00:00

abstract：:Progenitor cell fractions from normal human marrow have been prepared by a method that enables low numbers of cells to be cultured and results in very little T cell or monocyte contamination. The enrichment of 14- and 21-day BFU-E was similar to that for CFU-GM and the readdition of sheep red blood rosette-forming cel...

journal_title：Acta haematologica

authors： Linch DC,Boyle D,Beverley PC

更新日期：1982-01-01 00:00:00

abstract：:G-banded cytogenetic studies of 3 male patients in the terminal phase of chronic myeloid leukemia showed the following abnormalities: in the first case, the presence of a medullar cell line with 51 chromosomes and 3 Ph1; in the second case, a clone with 65 chromosomes and 4 Ph1, and in the third patient a clone with 5...

journal_title：Acta haematologica

authors： Cabrol C,Peytremann R,Maurice PA

更新日期：1982-01-01 00:00:00

abstract：:A 38-year-old Japanese man had suffered from trichophyton infection for several years. The white blood cell count was 20,300/mm3, including 54% abnormal lymphocytes with irregularly convoluted nuclei. Adult T-cell leukemia (ATL) was diagnosed based on proliferation of CD4-positive lymphocytes, positive anti-HTLV-I ant...

journal_title：Acta haematologica

authors： Okamura T,Shibuya T,Harada M,Niho Y

更新日期：1992-01-01 00:00:00

abstract：:Using enzyme-linked immunosorbent assay (ELISA) and confirmatory immunoprecipitation tests, sera from 640 Nigerians from Lagos and Cross River States were examined for antibodies against HIV. These comprised 570 blood donors and their family members, 56 patients with various haematological conditions and 14 patients w...

journal_title：Acta haematologica

authors： Okpara RA,Akinsete I,Williams EE,Schneider J,Wendler I,Hunsmann G

更新日期：1988-01-01 00:00:00

abstract：:Alpha-thalassemia is very common in the Kuwaiti population, but its influence on anemia of pregnancy has not been previously investigated. We have screened a group of 59 anemic (Hb < 11 g/dl) pregnant women for the alpha-thal-2 (-alpha-3.7 kb) deletion which is the commonest alpha-thal allele in this community, using ...

journal_title：Acta haematologica

authors： Diejomaoh FM,Haider MZ,Dalal H,Abdulaziz A,D'Souza TM,Adekile AD

更新日期：2000-01-01 00:00:00

abstract：:A patient with acute monoblastic leukemia developed a coagulopathy during chemotherapy. Coagulation studies showed thrombocytopenia, hypofibrinogenemia, high levels of fibrinogen degradation products, a negative protemine test but a normal antithrombin III level. These observations suggest that coagulation abnormaliti...

journal_title：Acta haematologica

authors： Vellenga E,Mulder NH

更新日期：1980-01-01 00:00:00

abstract：:Natural killer (NK) cell activity against K562 cell targets and the distribution of T cell subpopulations were investigated in the peripheral blood of 25 patients affected by beta thalassemia major, 18 clinically healthy heterozygotes, and 25 age-matched normal subjects. It was found that thalassemia major patients di...

journal_title：Acta haematologica

authors： Neri A,Brugiatelli M,Iacopino P,Callea V,Ronco F

更新日期：1984-01-01 00:00:00

abstract：:A 77-year-old woman presented to the outpatient hematology clinic in August 2001 with leukocytosis, recurrent bacterial infections, sweating and weight loss. Bone marrow biopsy showed 80% infiltration with lymphoid cells having a prolymphocytic morphology. Flow-cytometric immunophenotype analysis showed that over 80% ...

journal_title：Acta haematologica

authors： Zver S,Kokalj Vokac N,Zagradisnik B,Erjavec A,Zagorac A,Zupan IP,Cernelc P

更新日期：2004-01-01 00:00:00

abstract：:Patients with HIV-associated lymphocyte-depleted Hodgkin lymphoma (HIV-HL) often present with advanced, extranodal disease and aggressive clinical features, limiting definitive therapeutic intervention. Here we report two patients with HIV-HL who presented with multi-organ dysfunction as an initial manifestation of th...

journal_title：Acta haematologica

authors： Ding J,Kumar AJ,Wilding E,Lee ST,Law JY

更新日期：2020-01-01 00:00:00

abstract：:We describe two kindreds of Arab ancestry characterized by multiple cases of acute lymphoblastic leukemia. Consanguinity and intermarriages were prevalent in the two families. Age, mode of presentation, characteristics of the leukemic cells, response to treatment and prognosis were remarkably similar among the patient...

journal_title：Acta haematologica

authors： Kende G,Toren A,Mandel M,Neumann Y,Kenet G,Brok-Simoni F,Ramot B,Ben-Bassat I,Rechavi G

更新日期：1994-01-01 00:00:00

abstract：:Recently, the use of novel targeted drugs has changed the treatment paradigms in chronic lymphocytic leukemia (CLL). Among the several drugs used for the management of relapsed/refractory (R/R) CLL, Bruton tyrosine kinase inhibitors (ibrutinib and acalabrutinib), phosphatidylinositol 3-kinase inhibitors (idelalisib an...

journal_title：Acta haematologica

authors： Smolewski P,Robak T

更新日期：2020-11-25 00:00:00

abstract：:Upper-extremity deep venous thrombosis (UEDVT) is an increasingly important clinical problem in children. These events are classified as primary or secondary, with the latter being the most common and usually associated with the presence of a central venous line. Among primary UEDVT, the so-called Paget-Schroetter syn...

journal_title：Acta haematologica

authors： Brandão LR,Williams S,Kahr WH,Ryan C,Temple M,Chan AK

更新日期：2006-01-01 00:00:00

abstract：:Factor X inhibitors are rare. The few cases documented in the literature have occurred after viral prodromes, in association with cancer, or after exposure to antibiotics. Acquired factor X deficiencies are also rare and their etiology is largely unknown. We report a new case of a factor X inhibitor and review prior c...

journal_title：Acta haematologica

authors： Gollard R,Rahman S,Ratnasabapathy R

更新日期：2013-01-01 00:00:00

abstract：:We report the identification of an Hb S homozygosity in a 29-year-old multiple-transfused patient with severe kidney disease using a new reverse-transcription polymerase chain reaction (RT-PCR) technique with mRNA as starting template. The procedure requires considerably less time than sequencing of genomic DNA and is...

journal_title：Acta haematologica

authors： Smetanina NS,Gu LH,Leonova JYe,Huisman TH

更新日期：1995-01-01 00:00:00

abstract：:Multiple myeloma (MM) is a B cell malignancy characterized by accumulation of plasma cells (PCs) in the bone marrow. Traditional methods for the detection of minimal residual disease (MRD) measure the presence of monoclonal immunoglobulin protein secreted by the malignant PCs. However, changes in the level of MRD in M...

journal_title：Acta haematologica

authors： Rasmussen T,Knudsen LM,Huynh TK,Johnsen HE

更新日期：2004-01-01 00:00:00

abstract：:Platelet to leukocyte adhesion phenomena (PLAP) and the phagocytosis of platelets by neutrophils from the EDTA anticoagulated blood samples are described. PLAP was transferable to a normal blood specimen by patient's plasma or serum with or without complement. Further studies revealed in vitro evidence of hereditary p...

journal_title：Acta haematologica

authors： Yoo D,Weems H,Lessin LS

更新日期：1982-01-01 00:00:00

abstract：:The activity of gamma-glutamyl transpeptidase was investigated in normal and leukemia leukocytes. Enzyme activity was positively correlated with the proportion of mature neutrophils and monocytes. In isolated leukocytes from patients with acute myeloid leukemia low values were obtained compared to controls. ...

journal_title：Acta haematologica

authors： Hultberg B,Sjögren U

更新日期：1980-01-01 00:00:00

abstract：:Factor VII deficiency is the least rare among uncommon congenital coagulation disorders. The majority of cases are isolated deficiencies. In some cases, FVII deficiency has been found to be associated with the deficiency in another coagulation factor or with non-coagulation-related abnormalities or defects. The evalua...

journal_title：Acta haematologica

authors： Girolami A,Ruzzon E,Tezza F,Allemand E,Vettore S

更新日期：2007-01-01 00:00:00

abstract：:Patients with sickle cell disease have an increased tendency to develop frequent and severe pyogenic infections. Lymphocyte subpopulations were studied in 14 patients with homozygous sickle cell anaemia (SCA) using the OKT monoclonal antibody. The mean absolute lymphocyte counts observed in patients with SCA were simi...

journal_title：Acta haematologica

authors： Adedeji MO

更新日期：1985-01-01 00:00:00

abstract：:Malaria parasites growing inside human erythrocytes differ from mammalian cells in their mode of acquisition of bioavailable iron and in their susceptibility to the antiproliferative action of iron chelators. We have assessed here three major properties associated with these phenomena: (a) the stage-dependent nature o...

journal_title：Acta haematologica

authors： Cabantchik ZI,Glickstein H,Golenser J,Loyevsky M,Tsafack A

更新日期：1996-01-01 00:00:00

abstract：:A case of acute leukaemia with t(4;11) chromosomal abnormality in a 28-year-old woman is reported. At diagnosis, two blast cell populations were seen: 60% of the cells were small cells with lymphoid morphology, 40% were large cells with monocytic morphology. Cytochemical examination was consistent with acute myeloid l...

journal_title：Acta haematologica

authors： Campos L,Espinouse D,Felman P,Charrin C,Gentilhomme O,Germain D

更新日期：1986-01-01 00:00:00

abstract：:Two subjects, not previously reported in detail, had severe inherited deficiencies of erythrocyte pyrimidine nucleotidase. This was manifested hematologically by moderate hemolytic anemia with splenomegaly, morphologically by punctate basophilic stippling of Wright's stained erythrocytes, and biochemically by intraery...

journal_title：Acta haematologica

authors： Paglia DE,Fink K,Valentine WN

更新日期：1980-01-01 00:00:00

abstract：:Eltrombopag is a thrombopoietin receptor agonist frequently used to manage immune thrombocytopenia and aplastic anemia. At the high doses used for aplastic anemia, but not the doses used for immune thrombocytopenia, eltrombopag can cause reddish-brown discoloration of plasma, which can interfere with bilirubin measure...

journal_title：Acta haematologica

authors： Al-Samkari H,Goodarzi K

更新日期：2020-07-22 00:00:00

abstract：:Fetal hemoglobin (HbF) concentrations were measured by a radial immunodiffusion assay in 233 patients with various malignancies. In 96 of these, alpha-fetoprotein (AFP) was also measured by radioimmunoassay. The concentration of HbF exceeded 2 SDs above the normal mean in 39 of 233 patients, most notably in patients w...

journal_title：Acta haematologica

authors： Chudwin DS,Rucknagel DL,Scholnik AP,Waldmann TA,McIntire KR

更新日期：1977-01-01 00:00:00

abstract：:Amylase-producing tumors are mainly adenocarcinomas and, in rare instances, multiple myelomas. We describe here a first case of amylase-producing Bence Jones type myeloma with pancreatitis-like symptoms and the second in a Caucasian patient. The finding of salivary-type hyperamylasemia in a 72-year-old female with a p...

journal_title：Acta haematologica

authors： Lopez J,Ulibarrena C,Gonzalez-Porque P,Navas G,Roldan E,Cancelas JA,Perez-Oteyza J,Burgaleta C,García-Laraña J,Sastre JL

更新日期：1993-01-01 00:00:00

abstract：:A case of acquired haemophilia A presenting with extensive spontaneous bruising and anaemia is reported. The anaemia was due to myelodysplastic syndrome (FAB: refractory anaemia with ringed sideroblasts). A factor-VII:C-specific inhibitor was also found. Prednisone and pyridoxine were given, and the inhibitor became u...

journal_title：Acta haematologica

authors： Lin CK,Liang R,Liu HW,Tse PW,Chan GT

更新日期：1991-01-01 00:00:00

abstract：:Coagulation factor VIII inhibitor arising in a patient with autoimmune disease was immunologically analyzed. A 63-year-old man who had been diagnosed as suffering from polyarteritis nodosa was treated with prednisolone for 10 years. Severe bleeding tendency developed and coagulation studies demonstrated a high titer o...

journal_title：Acta haematologica

authors： Okamura T,Yamauchi Y,Fukuda T,Suehiro K,Murakawa M,Shibuya T,Nagasawa K,Harada M,Niho Y

更新日期：1991-01-01 00:00:00

abstract：:Chromosomal aberrations in a case of atypic myeloproliferative syndrome are reported. The analysis was carried out on short-term cultures of sternal bone marrow with the ASG and fluorescence method. 90% of the metaphases studied showed pseudoliploidy: one of the chromosomes 12 was missing and one submedian marker chro...

journal_title：Acta haematologica

authors： Fleischmann T,Krizsa F

更新日期：1975-01-01 00:00:00