Sickle cell anemia identified in a multiple-transfused patient through analysis of mRNA with an RT-PCR-based technique.

abstract：:A 29-year-old man with acute myelomonocytic leukemia had an initial leukocyte count of 192 X 10(9) cells/l and 84% blasts. During the initial treatment with hydroxyurea, 1 g/m2 orally tid, he developed pulmonary leukostasis which responded rapidly to whole-lung radiation with 1.5 Gy in one fraction. Pulmonary leukosta...

journal_title：Acta haematologica

authors： von Eyben FE,Siddiqui MZ,Spanos G

更新日期：1987-01-01 00:00:00

abstract：:Two patients with paraneoplastic cerebellar degeneration accompanying Hodgkin's disease were treated with plasma exchange in combination with chemotherapy or radiation therapy, respectively. Significant improvement in neurologic symptoms was obtained in 1 of them. ...

journal_title：Acta haematologica

authors： Cehreli C,Payzin B,Undar B,Yilmaz U,Alakavuklar MN

更新日期：1995-01-01 00:00:00

abstract：:Human beta-globin was produced in Escherichia coli as a cleavable fusion protein using the expression vector pLcII [Nagai and Thøgersen, Nature 301, p. 810, 1984]. The fusion protein CIIFX beta-globin was purified under denaturing conditions to homogeneity and the authentic beta-globin was liberated by blood coagulati...

journal_title：Acta haematologica

authors： Luisi BF,Nagai K,Perutz MF

更新日期：1987-01-01 00:00:00

abstract：:We evaluated the results of high-dose therapy (HDT) and autologous hematopoietic stem cell transplantation (ASCT) in patients with relapsed or primary refractory Hodgkin's disease (HD), using a previously reported prognostic model based on the presence of three poor prognostic factors at the start of salvage therapy/p...

journal_title：Acta haematologica

authors： Qazilbash MH,Devetten MP,Abraham J,Lynch JP,Beall CL,Auber M,Weisenborn R,Bunner P,Ericson SG

更新日期：2003-01-01 00:00:00

abstract：:Successive chromatographic procedures made it possible to isolate thrombocytopoietin from the serum of thrombocytopenic rats. The following steps were taken: DEAE-cellulose phosphate chromatography, Sephadex chromatography, exclusion chromatography on DEAE-Sephadex A-50 gel. The apparent molecular weight of thrombocyt...

journal_title：Acta haematologica

authors： Dassin E,Bourebia J,Najean Y,Rosset AM

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:We investigated the prevalence of opportunistic infections in HIV-infected women according to transferrin (TF) phenotype. METHODS:We conducted a cross-sectional study among 200 HIV-positive women in the Butare University Teaching Hospital in Rwanda. TF phenotypes were determined using starch gel electrophore...

journal_title：Acta haematologica

authors： Masaisa F,Gahutu JB,Mukiibi J,Delanghe J,Philippé J

更新日期：2012-01-01 00:00:00

abstract：:While sickle cell disease (SCD) is generally mild in most Kuwaitis, because of their elevated fetal Hb levels, avascular necrosis of the femoral head (AVNFH) appears to be a common complication. It was recently documented in 26.7% of Kuwaiti children with SCD. There have, however, been no previous studies of adult pat...

journal_title：Acta haematologica

authors： Marouf R,Gupta R,Haider MZ,Al-Wazzan H,Adekile AD

更新日期：2003-01-01 00:00:00

abstract：:Immunoglobulin light chain amyloidosis (AL amyloidosis) is a rare, life-threatening disease characterized by the deposition of misfolded proteins in vital organs such as the heart, the lungs, the kidneys, the peripheral nervous system, and the gastrointestinal tract. This causes a direct toxic effect, eventually leadi...

journal_title：Acta haematologica

authors： Van Doren L,Lentzsch S

更新日期：2020-01-01 00:00:00

abstract：:The dilution in the circulating blood of lymphocytes lablled in vitro with 3H-cytidine was examined after autotransfusion in 9 patients with Hodgkin's disease (HD) stage II A-IV B, 5 of whom were untreated; in 2 untreated patients with carcinoma, and in 1 treated patient with scleroderma. The blood transit time of exc...

journal_title：Acta haematologica

authors： Schick P,Trepel F,Eder M,Matzner M,Benedek S,Theml H,Kaboth W,Begemann H,Fliedner TM

更新日期：1975-01-01 00:00:00

abstract：:Thrombopoietin levels in thrombocytopenic mice assayed by 75Se-se-lenomethionine incorporation into blood platelets reached a maximum 12 h after the induction of an acute, immune thrombocytopenia; that was more than twice the value in control mice. The implications of this finding are discussed with reference to the k...

journal_title：Acta haematologica

authors： Nakeff A,Roozendaal KJ

更新日期：1975-01-01 00:00:00

abstract：:In a 42-year-old Caucasian female, acute myelocytic leukemia (M2) presented as occlusion of the distal aorta and right iliac artery. She died after 10 days of respiratory failure. At postmortem examination the aortic wall contained multiple thrombi composed of fibrin and leukemic cells. There was no evidence of diffus...

journal_title：Acta haematologica

authors： Kootte AM,Thompson J,Bruijn JA

更新日期：1986-01-01 00:00:00

abstract：:Human urinary erythropoietin has been purified to homogeneity. The seven-step procedure yielded a preparation with a potency of 225,000 U/mg protein. SDS-polyacrylamide gel electrophoretic analysis of the purified hormone revealed a single protein band with a molecular weight of about 35,000 that migrated with the bio...

journal_title：Acta haematologica

authors： Matsushita J,Kawakita M,Shibuya K,Koishihara Y,Sakaguchi M,Takatsuki A

更新日期：1990-01-01 00:00:00

abstract：:A case of lymphoma presenting with features shared by hairy cell leukemia (HCL) and its variant, intermediate lymphocytic lymphoma (ILL) and monocytoid B-cell lymphoma (MBCL) is described. Clinical presentation and the morphological findings observed in peripheral blood and in bone marrow biopsy suggested an HCL; howe...

journal_title：Acta haematologica

authors： Adami F,Chilosi M,Lestani M,Scarpa A,Zambello R,Pomponi F,Semenzato G,Menestrina F

更新日期：1993-01-01 00:00:00

abstract：:Low-dose cytosine arabinoside (ARA-C) induced complete remissions in 6 of 10 patients with acute non-lymphocytic leukaemia (ANLL) who were either refractory to combination chemotherapy with anthracyclines and conventional doses of ARA-C, or were in relapse. Three patients relapsed after 4, 19, and 20 months, whereas 3...

journal_title：Acta haematologica

authors： Krogh Jensen M,Stentoft J

更新日期：1986-01-01 00:00:00

abstract：:Agranulocytosis is a rare side effect of phenytoin treatment. We describe the case of an elderly man who developed agranulocytosis 2 weeks following initiation of phenytoin treatment, on no cytotoxic drugs or any other medications except decadron. The white blood cell count was 300/mm3 with absent granulocytes. The li...

journal_title：Acta haematologica

authors： Sharafuddin MJ,Spanheimer RG,McClune GL

更新日期：1991-01-01 00:00:00

abstract：:Thalidomide acts on the microenvironment of myelodysplastic syndromes (MDS) by influencing cytokine networks, and growing evidence supports thalidomide's usefulness in the management of haematological malignancies, such as MDS. The European Collaboration Group on Myelofibrosis with Myeloid Metaplasia reviewed patients...

journal_title：Acta haematologica

authors： Prentice HG,Sacchi S,Russell N

更新日期：2005-01-01 00:00:00

abstract：:The 8p11 myeloproliferative syndrome (EMS) is an aggressive neoplasm associated with chromosomal translocations involving the fibroblast growth factor receptor 1 (FGFR1) tyrosine kinase gene on chromosome 8p11-12. A new case of a 9-year-old boy with leukocytosis, eosinophilia, and general lymphadenopathy is reported i...

journal_title：Acta haematologica

authors： Lv H,Hu S,Lu J,Zhai Q,Zhai Z,Du Z,Sun Y,Li J,He H,Wang Y

更新日期：2018-01-01 00:00:00

abstract：:350 patients with idiopathic thrombocytopenic purpura (ITP) aged 2/12-15 years (mean 6.3 +/- 2.7) were followed up during the period January 1st, 1975 to March 31, 1992. They constituted 40% of cases with hemorrhagic diathesis attending the Hematology/Oncology Clinic, Children's Hospital, Ain Shams University (relativ...

journal_title：Acta haematologica

authors： Khalifa AS,Tolba KA,el-Alfy MS,Gadallah M,Ibrahim FH

更新日期：1993-01-01 00:00:00

abstract：:Recently, the use of novel targeted drugs has changed the treatment paradigms in chronic lymphocytic leukemia (CLL). Among the several drugs used for the management of relapsed/refractory (R/R) CLL, Bruton tyrosine kinase inhibitors (ibrutinib and acalabrutinib), phosphatidylinositol 3-kinase inhibitors (idelalisib an...

journal_title：Acta haematologica

authors： Smolewski P,Robak T

更新日期：2020-11-25 00:00:00

abstract：:A new case of IgE myeloma is described. A 77-year-old woman presented with bone pain and fatigue. Serum protein analysis revealed a paraprotein of the IgE kappa type; bone marrow aspirate and immunofluorescence confirmed the diagnosis; ultrastructural examination showed immature plasma cells. Treatment with prednisone...

journal_title：Acta haematologica

authors： Invernizzi F,Monti G,Caviglia AG,Meroni P,Zanussi C

更新日期：1991-01-01 00:00:00

abstract：:Although multiple myeloma (MM) remains an incurable disease, its treatment has improved over the past decade. This improvement has been at least in part due to the introduction of novel antimyeloma agents with new mechanisms of action, including those that target both myeloma cells and the tumor microenvironment, with...

journal_title：Acta haematologica

authors： Cibeira MT,Mercadal S,Arenillas L,Muntañola A,Salamero O,Bladé J

更新日期：2006-01-01 00:00:00

abstract：:A new deletion of the beta-globin gene cluster was characterized in a Turkish family. A 6-year-old male and his father were heterozygotes for this deletion. They presented with mild hypochromic microcytic anemia associated with elevated Hb F (15%) and normal Hb A2 levels (2.0%). This newly described Turkish type (delt...

journal_title：Acta haematologica

authors： Oner R,Oner C,Erdem G,Balkan H,Ozdağ H,Erkan M,Gümrük F,Gürgey A,Altay C

更新日期：1996-01-01 00:00:00

abstract：:Platelet to leukocyte adhesion phenomena (PLAP) and the phagocytosis of platelets by neutrophils from the EDTA anticoagulated blood samples are described. PLAP was transferable to a normal blood specimen by patient's plasma or serum with or without complement. Further studies revealed in vitro evidence of hereditary p...

journal_title：Acta haematologica

authors： Yoo D,Weems H,Lessin LS

更新日期：1982-01-01 00:00:00

abstract：:Platelet functions were evaluated in 20 healthy pregnant women in the last months of pregnancy, during labor, and 5-12 weeks after labor. The results showed an increased platelet count, bleeding time and nitroblue tetrazolium (NBT) test, as well as an increased plasma calcium level postlabor. ADP- and epinephrine-indu...

journal_title：Acta haematologica

authors： Sagi A,Creter D,Goldman J,Djaldetti M

更新日期：1981-01-01 00:00:00

abstract：:At our hospital, 47 out of 184 consecutive splenectomies performed over 7 recent years were carried out on patients afflicted with various hematologic diseases. The results of these 47 splenectomies were the subject of a careful retrospective analysis. The majority of the splenectomies (81%) were therapeutic. Cytopeni...

journal_title：Acta haematologica

authors： Dotevall A,Kutti J,Wadenvik H,Westin J,Angerås U,Darle N

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:The treatment of relapsed/refractory (R/R) peripheral T cell lymphoma (PTCL) is limited to a few agents. Romidepsin, a histone deacetylase inhibitor, was approved for PTCL treatment as a single agent in the R/R setting, yet with partial efficacy. Several attempts to combine romidepsin with other chemotherapy...

journal_title：Acta haematologica

authors： Nachmias B,Shaulov A,Lavie D,Goldschmidt N,Gural A,Saban R,Lebel E,Gatt ME

更新日期：2019-01-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an interferon (IFN)-induced molecule with apoptotic activity. We examined gene mutations in the death domains of TRAIL receptor 1 (TRAIL-R1) and TRAIL receptor 2 (TRAIL-R2), and in the TRAIL gene promoter in 46 chronic myelogenous leukemia (CML) patien...

journal_title：Acta haematologica

authors： Liu LG,Tanaka H,Ito K,Ito T,Sultana TA,Kyo T,Kimura A

更新日期：2005-01-01 00:00:00

abstract：:Leukemic cells of a patient with acute T-lymphoblastic leukemia (T-ALL) exhibiting the uncommon clinical feature of hypogammaglobulinemia were examined in terms of surface markers and immunologic functions. Employing various monoclonal reagents reacting with surface antigens present on T cells and additional conventio...

journal_title：Acta haematologica

authors： Herrmann F,Sieber G,Komischke B,Oestreich R,Rühl H

更新日期：1984-01-01 00:00:00

abstract：:A new variant of red cell glucose-6-phosphate dehydrogenase (G6PD) has been found in a Caucasian man with congenital non-spherocytic haemolytic anaemia. This variant has reduced activity, increased thermolability, increased Michaelis constants for glucose-6-phosphate and NADP, slightly increased electrophoretic mobili...

journal_title：Acta haematologica

authors： Mandelli F,Amadori S,De Laurenzi A,Kahn A,Isacchi G,Papa G

更新日期：1977-01-01 00:00:00

abstract：:The distribution of thymus-dependent (T cells) and bone marrow-derived lymphocytes (B cells) was studied in 74 patients with Hodgkin's disease and 33 normal controls. A T cell deficit was found in untreated patients as well as in long-term survivors in remission. Therapy slightly enhanced the T cell depletion in Hodgk...

journal_title：Acta haematologica

authors： Many A,Biniaminov M,Rosenthal E,Aghai E,Ramot B

更新日期：1976-01-01 00:00:00