Abstract：
:350 patients with idiopathic thrombocytopenic purpura (ITP) aged 2/12-15 years (mean 6.3 +/- 2.7) were followed up during the period January 1st, 1975 to March 31, 1992. They constituted 40% of cases with hemorrhagic diathesis attending the Hematology/Oncology Clinic, Children's Hospital, Ain Shams University (relative frequency of 37.4/100.000 of the general Out-Patient Clinic in the same hospital). These patients presented with acute (71.4%), chronic (22.9%) and recurrent (5.7%) forms. The age of presentation was younger in acute ITP. In the recurrent form there was significant female predominance. Most cases of acute ITP (66%) presented in winter and spring, with a positive history of preceding viral illness in 50% in contrast to 10% in chronic form. Four chronic ITP cases developed lupus erythematosus; all were females > 9 years. As regards therapy, acute ITP cases with initial platelet count (PC) < 10 x 10(9)/l were randomized to receive either high-dose methyl prednisolone (HDMP) 10 mg/kg/day for 5 days i.v. (n = 10) or intravenous immunoglobulin (IVIG) 0.4 g/kg/day for 5 days (n = 10) or conventional-dose prednisone (CDP) 2 mg/kg/day 4 weeks p.o. (n = 10). A dramatic response was noticed in the first two groups. In chronic ITP, (n = 80) CDP induced complete response (CR) in 30% and partial response (PR) in 20%; 50% were nonresponders. Twenty-four refractory ITP with persistent PC < or = 20 x 10(9)/l received second-line therapy: vincristine 1.5 mg/m2/week i.v. 4 doses (n = 4) with no clinical or hematological improvement. IVIG 0.4 g/kg/day for 5 days (n = 8) with sustained CR only in 2 patients (25%) and PR in 2 patients (25%). Splenectomy was performed (n = 12) with CR in 50%; out of them, 2 patients had shown no improvement on prior IVIG therapy. In conclusion, ITP is a benign condition with no fatality reported, but it could run a chronic refractory course.
journal_name
Acta Haematoljournal_title
Acta haematologicaauthors
Khalifa AS,Tolba KA,el-Alfy MS,Gadallah M,Ibrahim FHdoi
10.1159/000204392subject
Has Abstractpub_date
1993-01-01 00:00:00pages
125-9issue
3eissn
0001-5792issn
1421-9662journal_volume
90pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND/AIMS:The aim of this work was to investigate the efficacy and predictive factors of CLAG treatment in refractory or relapsed (R/R) acute myeloid leukemia (AML) patients. METHODS:Sixty-seven R/R AML patients were enrolled in this prospective cohort study and treated by a CLAG regimen: 5 mg/m2/day cladribine ...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000493250
更新日期：2019-01-01 00:00:00
abstract：:Essential thrombocythemia (ET), one of the chronic myeloproliferative disorders, is a clonal disorder of multipotent stem cells. Although most patients with ET have a prolonged benign course, a minority of patients may develop a blastic crisis similar to chronic myelogenous leukemia (CML). A case of ET terminating in ...
journal_title：Acta haematologica
pub_type： 杂志文章,评审
doi：10.1159/000204260
更新日期：1994-01-01 00:00:00
abstract：:The increased incidence of parallel tubular structures in lymphocytes of patients with Hodgkin's disease was investigated for a correlation with either impairment of cellular immunity (measured by DNCB-skin test and PHA-induced lymphocyte stimulation in vitro) or an increase of antibodies against cytomegalovirus or Ep...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000208056
更新日期：1975-01-01 00:00:00
abstract：BACKGROUND:Thalassemia is a group of hereditary hemoglobinopathies caused by decreased or absent synthesis of α and/or β globin chains. Studies have shown that hypercoagulability and thrombosis are common clinical symptoms in β-thalassemia, especially β-thalassemia intermedia, but little is known about in α-thalassemia...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000486157
更新日期：2018-01-01 00:00:00
abstract：:In order to study the abnormal differentiation and proliferation of precursor T cells in homosexual men, a study was made of T-cell colony formation in 15 healthy homosexual men without anti-human immunodeficiency virus (HIV) antibody. The colony forming method used was the one-step monolayer technique using phytohema...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000205374
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:In 2003, oral fludarabine was introduced in the USA for the treatment of patients with hematologic malignancies as an alternative to its intravenous (i.v.) formulation; in 2008, it was introduced in México while the i.v. formulation was withdrawn. Accordingly, i.v. fludarabine had to be replaced by oral flud...
journal_title：Acta haematologica
pub_type： 临床试验,杂志文章
doi：10.1159/000357108
更新日期：2014-01-01 00:00:00
abstract：:The expression of the enzyme marker terminal deoxynucleotidyl transferase (TdT) was examined by immunofluorescence assay in the cells from 333 cases with various types and subtypes of leukemia or lymphoma. More than 90% of cALL and T-ALL, 70% of Null-ALL and 80% of pre-B-ALL were TdT-positive. One case in the commonly...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206072
更新日期：1986-01-01 00:00:00
abstract：:Cancer patients not undergoing treatment and without a history of venous thrombosis do not, as a general rule, require prophylaxis. However, venous thromboembolism is of sufficient magnitude in patients undergoing treatment for cancer for thromboprophylaxis to be routinely employed. The mainstay of primary prevention ...
journal_title：Acta haematologica
pub_type： 杂志文章,评审
doi：10.1159/000046592
更新日期：2001-01-01 00:00:00
abstract：:A study was carried out of 332 babies suffering from severe neonatal jaundice who were admitted to the General Hospital, Kuala Lumpar, Malaysia. Of the 332 neonates, 51 were premature and 281 were full-term babies, 178 (110 Chinese, 58 Malay, 9 Indian and 1 European-Pakistani) had bilirubin levels of 20 mg% or higher,...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000207822
更新日期：1977-01-01 00:00:00
abstract：:Fetal liver transplantation was attempted in 7 patients with aplastic anemia. 4 of these patients showed a partial response as evidenced by decrease in blood transfusion requirements and increase in the peripheral blood counts and hematopoietic cells in the bone marrow. Bone marrow culture studies revealed evidence of...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000207558
更新日期：1979-01-01 00:00:00
abstract：:Treatment options are limited for patients with advanced forms of myeloproliferative neoplasms (MPN) including blast-phase disease (MPN-BP). Decitabine has frequently been deployed but its efficacy and safety profile are not well described in this population. We retrospectively reviewed 42 patients treated with decita...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000506146
更新日期：2021-01-01 00:00:00
abstract：:The activity of gamma-glutamyl transpeptidase was investigated in normal and leukemia leukocytes. Enzyme activity was positively correlated with the proportion of mature neutrophils and monocytes. In isolated leukocytes from patients with acute myeloid leukemia low values were obtained compared to controls. ...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000207384
更新日期：1980-01-01 00:00:00
abstract：:Agranulocytosis developed in a 20-year-old Greek patient with beta-thalassaemia major, 11 weeks after commencing chelation with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) and 6 weeks after receiving the drug at a total daily dose of 105 mg/kg. The patient presented with generalised weakness, low-gra...
journal_title：Acta haematologica
pub_type： 临床试验,杂志文章
doi：10.1159/000204494
更新日期：1993-01-01 00:00:00
abstract：:Afibrinogenaemia in a female Saudi child is reported. Two siblings died of bleeding. The parents, who are first cousins, a brother and two sisters are asymptomatic heterozygotes with fibrinogen levels of less than 1.5 g/l. The presentation was described and compared to other cases reported. ...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206624
更新日期：1984-01-01 00:00:00
abstract：:Recently, a factor was discovered in the serum of hepatectomized animals which was capable of augmenting the hepatic erythropoietin response to hypoxia when injected into normal rats. This substance was localized in the liver via an in situ perfusion technique and was termed the hepatic erythropoietic factor (HEF). Pa...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206884
更新日期：1983-01-01 00:00:00
abstract：:In 34 patients with chronic lymphatic leukaemia (CLL) the lymphocytes have been separated and sized using a C1000 Channelyzer. The modal volume and the volume range of the populations have been obtained and related to clinical stage and mouse red blood cell (MRBC) rosetting capacity. Over 1 year's observation with sev...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206714
更新日期：1983-01-01 00:00:00
abstract：:The distribution of thymus-dependent (T cells) and bone marrow-derived lymphocytes (B cells) was studied in 74 patients with Hodgkin's disease and 33 normal controls. A T cell deficit was found in untreated patients as well as in long-term survivors in remission. Therapy slightly enhanced the T cell depletion in Hodgk...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000207911
更新日期：1976-01-01 00:00:00
abstract：:A 51-year-old male with acute lymphoblastic leukemia whose course was complicated by primary fibrinolysis and spontaneous rupture of the spleen is described. The patient was treated with various drug combinations: vincristine and prednisone, later by cytosine arabinoside and finally by prednisone, methotrexate and 6-m...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000207962
更新日期：1976-01-01 00:00:00
abstract：:A case of systemic mastocytosis with unusual clinical manifestations, appearing as an isolated splenohepatomegaly, is described. The proliferative character is evident from the cytological characteristics of immaturity and the presence of a moderate percentage of mast cells in the peripheral blood. These cells make up...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000207846
更新日期：1977-01-01 00:00:00
abstract：:An unusual complication of chronic lymphocytic leukemia (CLL) is reported. The patient, a 79-year-old man, had a long standing history of CLL, that had been complicated by the development of a Guillain-Barré-like syndrome and a peripheral biclonal gammopathy. The biclonal immunoglobulins identified in the serum were I...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000204593
更新日期：1992-01-01 00:00:00
abstract：:Chronic graft-versus-host disease (GVHD) is a severe complication of allogeneic stem cell transplantation, with a substantial impact on the quality of life and survival, still lacking with regard to an optimal therapeutic strategy. Corticosteroids are considered the standard of care for first-line treatment of chronic...
journal_title：Acta haematologica
pub_type： 杂志文章,评审
doi：10.1159/000345836
更新日期：2013-01-01 00:00:00
abstract：:We report the identification of an Hb S homozygosity in a 29-year-old multiple-transfused patient with severe kidney disease using a new reverse-transcription polymerase chain reaction (RT-PCR) technique with mRNA as starting template. The procedure requires considerably less time than sequencing of genomic DNA and is...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000204121
更新日期：1995-01-01 00:00:00
abstract：:The short-term effect of a domestically produced equine antithymocyte globulin (ATG) was analyzed in 6 patients with acquired severe aplastic anemia (AA). All patients received 5 doses of ATG every other day in a 60-min intravenous infusion. Five peripheral blood immunoregulatory mononuclear cell (MNC) subsets, define...
journal_title：Acta haematologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1159/000205557
更新日期：1989-01-01 00:00:00
abstract：:B6D2F1 female mice were intravenously administered 0.4 mg of glucan. 1, 5, 11, and 17 days later, the total nucleated cellularity (TNC) and the numbers of pluripotent hemopoietic stem cells (CFU-s), granulocyte-macrophage progenitor cells (GM-CFC), and erythroid colony-forming (CFU-e) and burst-forming (BFU-e) cells w...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206753
更新日期：1983-01-01 00:00:00
abstract：:It was found that neutrophils in untreated uraemic patients as well as in subjects on regular dialysis treatment displayed higher activity of acid phosphatase, alkaline phosphatase and peroxidase. Spontaneous reduction of nitro blue tetrazolium (NBT) by granulocytes was also higher in both groups in comparison to cont...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000207647
更新日期：1979-01-01 00:00:00
abstract：:We review the problem of lymphoma classification in the light of the Revised European-American Lymphoma (REAL) scheme, recently proposed by the International Lymphoma Study Group (ILSG). The REAL classification is a list of clinicopathologic entities, all well known from the literature, upon which the ILSG members agr...
journal_title：Acta haematologica
pub_type： 杂志文章,评审
doi：10.1159/000203875
更新日期：1996-01-01 00:00:00
abstract：:Upper-extremity deep venous thrombosis (UEDVT) is an increasingly important clinical problem in children. These events are classified as primary or secondary, with the latter being the most common and usually associated with the presence of a central venous line. Among primary UEDVT, the so-called Paget-Schroetter syn...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000090939
更新日期：2006-01-01 00:00:00
abstract：:Plasma samples from patients with disseminated intravascular coagulation (DIC) associated with acute promyelocytic leukemia (APL) exhibited higher levels of the D-fragment of fibrin and fibrinogen degradation products [FDP(D)], with relatively lower levels of cross-linked fibrin degradation products (XDP), than sample...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000205392
更新日期：1989-01-01 00:00:00
abstract：:Two pregnancies at risk for Fanconi's anemia have been monitored by a cytogenetic method in the first trimester of gestation. The rate of chromosome breakage was evaluated in spontaneous mitoses from a direct preparation of trophoblasts in one case and from mitoses obtained from standard cultures and from mitoses trea...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000206309
更新日期：1985-01-01 00:00:00
abstract：:In evaluating hypoimmunoglobulinemia in a patient with nonsecretory myeloma, studies of in vitro immunoglobulin synthesis were performed during a 3-year period. Impaired polyclonal response to mitogen stimulation associated with excessive suppressor activity was demonstrable at diagnosis. Despite successful chemothera...
journal_title：Acta haematologica
pub_type： 杂志文章
doi：10.1159/000205622
更新日期：1988-01-01 00:00:00
