Abstract:
:The short-term effect of a domestically produced equine antithymocyte globulin (ATG) was analyzed in 6 patients with acquired severe aplastic anemia (AA). All patients received 5 doses of ATG every other day in a 60-min intravenous infusion. Five peripheral blood immunoregulatory mononuclear cell (MNC) subsets, defined by monoclonal antibodies, were enumerated before and 24 h after each application of ATG. Following the first dose of ATG there was a significant and transient reduction in the absolute number of helper T lymphocytes. There was no statistically significant difference pre-ATG to post-ATG in the absolute number of MNC expressing activation antigen Tac (interleukin-2 receptor). However, Tac+ cells, which were significantly increased before ATG therapy, decreased to nearly normal levels after the fourth dose of ATG. A significant and sustained increment in the absolute number of monocytes (CD14+ cells) occurred following the third dose of ATG. The absolute numbers of MNC, suppressor T lymphocytes and cells bearing HLA-DR antigen remain without significant change along ATG treatment. These results suggest that: (a) Tac+ cells are probably involved in the pathogenesis of AA; (b) the target of ATG may be a Tac+ cell, and (c) ATG may stimulate monopoiesis.
journal_name
Acta Haematoljournal_title
Acta haematologicaauthors
López-Karpovitch X,Zarzosa ME,Cárdenas MR,Piedras Jdoi
10.1159/000205557subject
Has Abstractpub_date
1989-01-01 00:00:00pages
176-80issue
4eissn
0001-5792issn
1421-9662journal_volume
81pub_type
临床试验,杂志文章,随机对照试验abstract::It has been found possible to test ferritin concentrations in the reticulum and hemopoietic cells from human bone marrow by an immunoradiometric assay. Ferritin concentration in healthy test persons amounts to 0.92 +/- 0.38 ng/microgram protein in the reticulum and 0.084 +/- 0.031 ng/microgram protein in hemopoietic c...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207030
更新日期:1982-01-01 00:00:00
abstract::Successive chromatographic procedures made it possible to isolate thrombocytopoietin from the serum of thrombocytopenic rats. The following steps were taken: DEAE-cellulose phosphate chromatography, Sephadex chromatography, exclusion chromatography on DEAE-Sephadex A-50 gel. The apparent molecular weight of thrombocyt...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206900
更新日期:1983-01-01 00:00:00
abstract::We report a patient with myelodysplastic syndrome (MDS), refractory anaemia with excess blasts in transformation, in whom complete remission (CR) was achieved with the administration of granulocyte colony-stimulating factor (G-CSF). The 76-year-old patient was admitted to our hospital with a fever and a productive cou...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000057637
更新日期:2002-01-01 00:00:00
abstract::A patient developed a drug rash and neutropenia while receiving tobramycin, ticarcillin and flucloxacillin intravenously for osteomyelitis. Incorporation of these antibiotics into in vitro cultures of bone marrow granulocyte macrophage precursors (CFU-C) showed no inhibition of the patient's marrow or normal marrow by...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206794
更新日期:1983-01-01 00:00:00
abstract::Coagulation factor VIII inhibitor arising in a patient with autoimmune disease was immunologically analyzed. A 63-year-old man who had been diagnosed as suffering from polyarteritis nodosa was treated with prednisolone for 10 years. Severe bleeding tendency developed and coagulation studies demonstrated a high titer o...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204879
更新日期:1991-01-01 00:00:00
abstract::A 59-year-old man with beta-thalassaemia major is unusually well. He has no beta-chains in his haemoglobin but is heterozygous for the genes responsible for alphaA and for alphaG Philadelphia. In addition he is also heterozygous for the genes responsible for gammaF and a new gamma-chain, gamma75(E19) Ile-Thr, named ga...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000208204
更新日期:1975-01-01 00:00:00
abstract::The clinical pattern of haemolysis associated with Donath-Landsteiner antibodies has undergone a change over the years. In the current study 13 patients developed the acute form of the disease whilst only 1 presented with the classical picture of chronic paroxysmal cold haemoglobinuria. The acute illness typically occ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206992
更新日期:1982-01-01 00:00:00
abstract::Monosomy 7 myelodysplasia is a rare hematological entity and is associated with morphological abnormalities in bone marrow and peripheral smear, and poor prognosis in children. We describe 2 children with infantile monosomy 7 myelodysplasia which evolved to leukemia. One of them died after 1 month, and the other is st...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204135
更新日期:1994-01-01 00:00:00
abstract::The case history of a 71-year-old woman with three episodes of a microangiopathic hemolytic anemia over a 22-year span is detailed. During the last episode a possible response of her thrombotic thrombocytopenic purpura (TTP)-like syndrome to the administration of intravenous immunoglobulin is documented. In retrospect...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000205377
更新日期:1989-01-01 00:00:00
abstract::Human urinary erythropoietin has been purified to homogeneity. The seven-step procedure yielded a preparation with a potency of 225,000 U/mg protein. SDS-polyacrylamide gel electrophoretic analysis of the purified hormone revealed a single protein band with a molecular weight of about 35,000 that migrated with the bio...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205057
更新日期:1990-01-01 00:00:00
abstract::The Philadelphia chromosome-negative myeloproliferative disorders (MPDs) polycythemia vera (PV), essential thrombocytosis (ET) and primary myelofibrosis (PMF) are characterized by increased proliferation of terminally differentiated myeloid cells. Although these disorders were recognized as clonal hematopoietic stem c...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000140634
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:The aim of this investigation was to study the effect of vitamin E treatment in oxidative stress of red and white cells of beta-thalassaemia intermedia patients. METHODS:Nine patients undergoing occasional transfusions (5 females/4 males), median age 39 years (range 15-74), were recruited for oral daily admi...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000201988
更新日期:2008-01-01 00:00:00
abstract::Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative myeloproliferative neoplasms. Preclinical results support that JAK2 inhibitors could show efficacy in treating chronic myeloproliferative neopla...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000356784
更新日期:2014-01-01 00:00:00
abstract::Factor VIII (FVIII) inhibitor antibodies are produced against functional epitopes of FVIII in about 30% of severe hemophilia A patients leading to inhibition of its procoagulant activity. The Bethesda assay, the most commonly used method to measure FVIII inhibitors, based on inhibition of coagulant activity of FVIII, ...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000086580
更新日期:2005-01-01 00:00:00
abstract::We review the problem of lymphoma classification in the light of the Revised European-American Lymphoma (REAL) scheme, recently proposed by the International Lymphoma Study Group (ILSG). The REAL classification is a list of clinicopathologic entities, all well known from the literature, upon which the ILSG members agr...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000203875
更新日期:1996-01-01 00:00:00
abstract::Pleural effusion in chronic lymphocytic leukemia (CLL) is a relatively rare phenomenon. We report a case of a pleural effusion associated with B-cell CLL but with predominantly reactive T lymphocytes in the effusion. A cell surface phenotype study showed that T lymphocytes predominated in the pleural effusion, althoug...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000203713
更新日期:1996-01-01 00:00:00
abstract::We describe two kindreds of Arab ancestry characterized by multiple cases of acute lymphoblastic leukemia. Consanguinity and intermarriages were prevalent in the two families. Age, mode of presentation, characteristics of the leukemic cells, response to treatment and prognosis were remarkably similar among the patient...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204222
更新日期:1994-01-01 00:00:00
abstract::Extensive bone marrow necrosis and symptomatic hypercalcemia have been described independently as rare complications of chronic myeloid leukemia. Here we report a 66-year-old man who developed B cell blastic transformation 10 years after diagnosis of CML in the chronic phase. Extensive bone marrow necrosis and symptom...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000106100
更新日期:2007-01-01 00:00:00
abstract::G-banded cytogenetic studies of 3 male patients in the terminal phase of chronic myeloid leukemia showed the following abnormalities: in the first case, the presence of a medullar cell line with 51 chromosomes and 3 Ph1; in the second case, a clone with 65 chromosomes and 4 Ph1, and in the third patient a clone with 5...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207047
更新日期:1982-01-01 00:00:00
abstract::Thymoma is an uncommon neoplasia derived from the epithelial cells of the thymus, which leads to immune dysregulation and is associated with a series of autoimmune diseases. However, the concurrence of these disease entities is rare, and the exact mechanisms of these diseases are still unclear. We have admitted severa...
journal_title:Acta haematologica
pub_type:
doi:10.1159/000503376
更新日期:2020-01-01 00:00:00
abstract::In a case of preleukemic dyserythropoiesis, in vitro red cell lysis tests showed a positive acidified serum test whose characteristics are described. The positive acidified serum test occurred in 10 normal sera, in 1 serum with complete deficiency of the fourth component of complement and in 1 serum with complete defi...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207748
更新日期:1978-01-01 00:00:00
abstract::In most patients with large granular lymphocyte (LGL) leukemia, the disease appears to progress slowly if at all, and no therapy is generally required. We present a patient with CD3+ CD8+ CD16+ LGL leukemia, who showed a benign clinical course for more than 7 months without therapy, but subsequently developed aggressi...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000204336
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:The treatment of relapsed/refractory (R/R) peripheral T cell lymphoma (PTCL) is limited to a few agents. Romidepsin, a histone deacetylase inhibitor, was approved for PTCL treatment as a single agent in the R/R setting, yet with partial efficacy. Several attempts to combine romidepsin with other chemotherapy...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000498905
更新日期:2019-01-01 00:00:00
abstract::A study of E-rosette ultrathin sections has been undertaken in an attempt to analyze changes induced during the T-lymphocyte-sheep red blood cell interaction on the rosetted lymphocyte surface architecture. The formation of nonimmune rosettes implies different types of attachment between lymphocytes and sheep red bloo...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000207570
更新日期:1979-01-01 00:00:00
abstract::To test whether anti-idiotypic immunoregulation of factor VIII(FVIII)-inhibiting antibodies could be feasible in hemophiliacs, we assayed the minimal number and range of immunogenic, functional FVIII epitopes to which a series of murine anti-FVIII monoclonal antibodies (MAb) were directed. Rabbit anti-idiotypic sera t...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000205171
更新日期:1990-01-01 00:00:00
abstract::von Willebrand disease (VWD) type 2M is a distinct entity and clearly differs from type 1. The genotype-phenotype correlation for cases with ristocetin cofactor activity (RCo)/antigen (Ag) ratios <0.60 is clear, whereas the von Willebrand factor (VWF):collagen binding (CB)/VWF:Ag ratio is normal in VWD 2M. Typical lab...
journal_title:Acta haematologica
pub_type: 杂志文章,评审
doi:10.1159/000214854
更新日期:2009-01-01 00:00:00
abstract::Factor X inhibitors are rare. The few cases documented in the literature have occurred after viral prodromes, in association with cancer, or after exposure to antibiotics. Acquired factor X deficiencies are also rare and their etiology is largely unknown. We report a new case of a factor X inhibitor and review prior c...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000342115
更新日期:2013-01-01 00:00:00
abstract::Fibroblast-like cells were grown from the bone marrow of acute lymphoblastic leukemia (ALL) patients before, during and off therapy. A diminished growth capacity was observed in cells from patients before and during therapy. In the three groups studied, differences were also observed in the effect of hydrocortisone on...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000206284
更新日期:1985-01-01 00:00:00
abstract::To evaluate the effect of granulocyte/colony-stimulating factor (G-CSF) on the onset of the adult respiratory distress syndrome (ARDS), we investigated whether the incidence of ARDS due to pulmonary infection differed between the G-CSF group which received chemotherapy with G-CSF and historical controls without G-CSF....
journal_title:Acta haematologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000040937
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:We aimed to determine the effects of intravenous iron therapy on blood parameters in pediatric patients who do not tolerate oral iron therapy for any reason. PATIENTS AND METHODS:The patient group consisted of candidates for elective operations requiring blood transfusions in order to raise hemoglobin (Hb) c...
journal_title:Acta haematologica
pub_type: 杂志文章
doi:10.1159/000092348
更新日期:2006-01-01 00:00:00