Factor VIII epitopes recognized with inhibitory monoclonal antibodies.

abstract：:A 64-year-old man with multiple sclerosis developed a circulating anticoagulant. Three immunoglobulin fractions (I = IgG; II =IgG+IgA; III = IgM) were separated from patient serum by 33-percent ammonium sulfate precipitation and DEAE-52 cellulose column chromatography. Fractions I (IgG) and II (IgG+IgA) had factor VII...

journal_title：Acta haematologica

authors： Moake JL,Kent CJ,Meta LD,Wright LC

更新日期：1976-01-01 00:00:00

abstract：:Total and unsaturated folate binding capacity (TFBC, UFBC) have been measured in sera of selective groups of patients to study the role of cell turnover, cell necrosis and the effect of pregnancy in determining their concentrations in blood. The mean value of TFBC in 35 normal sera was 151 +/- (SD) 53 pg/ml with a sat...

journal_title：Acta haematologica

authors： Corrocher R,Bambara LM,Pachor ML,Biasi D,Stanzial A,De Sandre G

更新日期：1979-01-01 00:00:00

abstract：:A case of multiple pyarthroses due to Staphylococcus aureus occurring in a severe classical hemophiliac is presented. Successful management depended on drainage of the infected joints and a prolonged course of antibiotics. Several criteria are suggested for recognition of hemophiliacs who might benefit from joint aspi...

journal_title：Acta haematologica

authors： Goldsmith JC,Silberstein PT,Fromm RE Jr,Walker DY

更新日期：1984-01-01 00:00:00

abstract：:Cardiac scintigraphy has been performed in 60 beta-thalassaemia major patients aged 8-35 years who received regular blood transfusions and subcutaneous desferrioxamine (DFX) chelation. Fifty-seven showed no clinical, radiological or electrocardiographic evidence of heart disease and 3 had clinically apparent cardiac f...

journal_title：Acta haematologica

authors： Aldouri MA,Wonke B,Hoffbrand AV,Flynn DM,Ward SE,Agnew JE,Hilson AJ

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:We aimed to determine the effects of intravenous iron therapy on blood parameters in pediatric patients who do not tolerate oral iron therapy for any reason. PATIENTS AND METHODS:The patient group consisted of candidates for elective operations requiring blood transfusions in order to raise hemoglobin (Hb) c...

journal_title：Acta haematologica

authors： Akarsu S,Taskin E,Yilmaz E,Yilmaz H,Kilic M,Aygun AD

更新日期：2006-01-01 00:00:00

abstract：:Inferferon alfa-2b (IFN) plays a major role in the current management of previously untreated patients with chronic myelogenous leukemia (CML) as well as patients with CML who have relapsed after bone marrow transplantation. Hydroxyurea (HU) is the best conventional drug for treatment of CML in the chronic phase. Ten ...

journal_title：Acta haematologica

authors： Bourantas KL,Syrou M,Tsiara S,Danella M,Konstantinides P

更新日期：1996-01-01 00:00:00

abstract：:Littoral cell angioma (LCA) is a rare vascular tumor of the spleen with an unknown etiology and unclear natural history. An association with synchronous malignancy has been described. We report the case of a 54-year-old woman who had progressive splenomegaly over 3 years following resection of a colon adenocarcinoma. ...

journal_title：Acta haematologica

authors： Steensma DP,Morice WG

更新日期：2000-01-01 00:00:00

abstract：:The short-term effect of a domestically produced equine antithymocyte globulin (ATG) was analyzed in 6 patients with acquired severe aplastic anemia (AA). All patients received 5 doses of ATG every other day in a 60-min intravenous infusion. Five peripheral blood immunoregulatory mononuclear cell (MNC) subsets, define...

journal_title：Acta haematologica

authors： López-Karpovitch X,Zarzosa ME,Cárdenas MR,Piedras J

更新日期：1989-01-01 00:00:00

abstract：:We have studied the amount and intracellular distribution of erythroblastic alkaline and acid phosphatase, nonspecific esterase, and N-acetyl-beta-glucosaminidase in 50 patients with acquired dyserythropoiesis. 19 morphologically normal bone marrow smears served as controls. Alkaline phosphatase was found in all contr...

journal_title：Acta haematologica

authors： Woessner S,Lafuente R,Florensa L,Sans-Sabrafen J

更新日期：1984-01-01 00:00:00

abstract：:Recombinant alpha-interferons are used as therapeutic agents in an increasing number of benign and malignant disorders. Long-term administration of recombinant alpha-interferon as a maintenance agent is associated with a small number of adverse side-effects which are responsible for patient intolerance of this drug. T...

journal_title：Acta haematologica

authors： Giles FJ,Worman CP,Jewell AP,Goldstone AH

更新日期：1991-01-01 00:00:00

abstract：:This paper presents data on the occurrence and pattern of inherited bleeding syndromes (IBS) in Jordan, a hitherto unexplored problem. In 1978, during the first 12 months of a prospective study at a major medical center, 91 patients from 51 families were diagnosed as having IBS. All patients were referred because of m...

journal_title：Acta haematologica

authors： Alsabti EA,Hammadi M

更新日期：1979-01-01 00:00:00

abstract：:A rare case of acute promyelcytic leukemia (APL) is reported in a 7-year-old boy. The patient displayed the typical features of APL including impaction of the marrow with promyelocytes, marked elevation of the serum vitamin B12 and transcobalamin I levels and a hemorrhagic diathesis. The bleeding diathesis in the case...

journal_title：Acta haematologica

authors： Engelhard D,Yatziv S,Rachmilewitz EA,Polliack A

更新日期：1979-01-01 00:00:00

abstract：:Pleural effusion in chronic lymphocytic leukemia (CLL) is a relatively rare phenomenon. We report a case of a pleural effusion associated with B-cell CLL but with predominantly reactive T lymphocytes in the effusion. A cell surface phenotype study showed that T lymphocytes predominated in the pleural effusion, althoug...

journal_title：Acta haematologica

authors： Miyahara M,Shimamoto Y,Sano M,Nakano H,Shibata K,Matsuzaki M

更新日期：1996-01-01 00:00:00

abstract：:In the diagnosis of multiple myeloma (MM), the radiological skeletal survey (RSS) was proven to be most useful for the detection of bone lesions. Since 1961, a new technique radioisotopic bone scan (RIBS), for the detection of such lesions, using 85Sr and 99mTc, has been shown to be highly sensitive for the detection ...

journal_title：Acta haematologica

authors： Tamir R,Glanz I,Lubin E,Vana D,Pick AI

更新日期：1983-01-01 00:00:00

abstract：:A case of lymphoma presenting with features shared by hairy cell leukemia (HCL) and its variant, intermediate lymphocytic lymphoma (ILL) and monocytoid B-cell lymphoma (MBCL) is described. Clinical presentation and the morphological findings observed in peripheral blood and in bone marrow biopsy suggested an HCL; howe...

journal_title：Acta haematologica

authors： Adami F,Chilosi M,Lestani M,Scarpa A,Zambello R,Pomponi F,Semenzato G,Menestrina F

更新日期：1993-01-01 00:00:00

abstract：:We have demonstrated the log normality of the distribution of sheep rosette-forming cells and mouse rosette-forming cells' values obtained with lymphocytes isolated from the peripheral blood of 135 healthy human beings and 57 patients suffering from chronic lymphocytic leukemia and well differentiated lymphocytic lymp...

journal_title：Acta haematologica

authors： Beaumariage ML,Focan C

更新日期：1978-01-01 00:00:00

abstract：:Using labelled erythrocytes and human serum albumin, the volume of circulating erythrocytes and plasma was determined in the spleen and individual parts of the skeleton of mice under physiological conditions and 48 h after X-irradiation with a dose of 2,87 Gy. The results are significant for the interpretation of the ...

journal_title：Acta haematologica

authors： Vácha J,Holá J,Dungel J,Znojil V

更新日期：1980-01-01 00:00:00

abstract：:Iron deficiency is the main cause of anemia in both sexes, with women being more commonly affected. Iron therapy is currently considered an effective and safe remedy to replenish the iron storages. Iron can be administrated both orally and intravenously. In particular, intravenous (IV) iron therapy is widely used when...

journal_title：Acta haematologica

authors： Di Girolamo A,Albanesi M,Loconte F,Di Bona D,Caiaffa MF,Macchia L

更新日期：2020-01-01 00:00:00

abstract：:Bone marrow fragments from 10 patients with a megaloblastic anaemia due to vitamin B12 or folate deficiency were studied by electron microscopy and electron microscope autoradiography. A proportion of the erythroblasts showed ultrastructural abnormalities. Some of the cells containing autophagic vacuoles, large sidero...

journal_title：Acta haematologica

authors： Wickramasinghe SN,Bush V

更新日期：1977-01-01 00:00:00

abstract：:Posttransplant lymphoproliferative disorders (PTLD) are a potentially life-threatening complication of immunosuppression in transplant recipients. The majority of cases are Epstein-Barr virus-associated lesions of B cell origin. T cell PTLD is rare, particularly in pediatric patients. We present an unusual case of mon...

journal_title：Acta haematologica

authors： Kraus TS,Twist CJ,Tan BT

更新日期：2014-01-01 00:00:00

abstract：:Factor X inhibitors are rare. The few cases documented in the literature have occurred after viral prodromes, in association with cancer, or after exposure to antibiotics. Acquired factor X deficiencies are also rare and their etiology is largely unknown. We report a new case of a factor X inhibitor and review prior c...

journal_title：Acta haematologica

authors： Gollard R,Rahman S,Ratnasabapathy R

更新日期：2013-01-01 00:00:00

abstract：:Two patients with paraneoplastic cerebellar degeneration accompanying Hodgkin's disease were treated with plasma exchange in combination with chemotherapy or radiation therapy, respectively. Significant improvement in neurologic symptoms was obtained in 1 of them. ...

journal_title：Acta haematologica

authors： Cehreli C,Payzin B,Undar B,Yilmaz U,Alakavuklar MN

更新日期：1995-01-01 00:00:00

abstract：:Fas/APO-1 (CD95) is a cell surface molecule that can transduce apoptotic signals into cells. We examined the expression of Fas antigen on CD4+ and CD8+ T cells of patients who received total body irradiation (TBI) as a preparative regimen for allogeneic bone marrow transplantation. Numbers of peripheral blood lymphocy...

journal_title：Acta haematologica

authors： Fujimori Y,Saheki K,Itoi H,Okamamoto T,Kakishita E

更新日期：2000-01-01 00:00:00

abstract：:A 74-year-old woman was treated by lithium carbonate 3 x 300 mg per day for drug-induced aplastic anemia. After 8 days, she suddenly developed severe impairment of consciousness with myoclonias and hypertonia which persisted during 10 days despite lithium withdrawal and sodium chloride infusion. Slight disorders of wa...

journal_title：Acta haematologica

authors： Efira A,van Laethem Y,Ectors M,Unger J

更新日期：1980-01-01 00:00:00

abstract：:Platelet aggregation in diabetic retinopathy was investigated in a group of 25 patients. An enhanced activity induced by epinephrine and arachidonic acid was found in this group as compared with the controls, whereas in adenosine diphosphate (ADP) platelet aggregation no differences were observed. Spontaneous aggregat...

journal_title：Acta haematologica

authors： Creter D,Pavlotzky F,Savir H

更新日期：1978-01-01 00:00:00

abstract：:It has been proposed that iron overload may adversely affect liver disease outcome. The recent identification of 2 mutations in the HFE gene related to hereditary haemochromatosis (Cys282Tyr and His63Asp) provided an opportunity to test whether they are associated with hepatic iron accumulation and the activity and se...

journal_title：Acta haematologica

authors： Martinelli AL,Franco RF,Villanova MG,Figueiredo JF,Secaf M,Tavella MH,Ramalho LN,Zucoloto S,Zago MA

更新日期：2000-01-01 00:00:00

abstract：:34 patients with myocardial infarction were studied with daily measurements of beta-thromboglobulin (BTG) and 125I fibrinogen scanning in order to detect deep-venous thrombosis (DVT). Serial levels of BTG were unhelpful in the early detection of this condition, which occurred in 7 of the patients studied. 5 of the pat...

journal_title：Acta haematologica

authors： Simmonds JP,O'Malley BP,Maskill MR,O'Connor JF,Burridge DJ

更新日期：1980-01-01 00:00:00

abstract：:Treatment of acute lymphoblastic leukemia is unsatisfactory in adults due to disease and patient-related factors and probably because adult chemotherapy regimens are weaker than pediatric protocols. Worries about inadequacy of adult regimens urged many hematologists, including us, to reconsider their routine treatment...

journal_title：Acta haematologica

authors： Buyukasik Y,Acar K,Kelkitli E,Uz B,Serefhanoglu S,Ozdemir E,Pamukcuoglu M,Atay H,Bektas O,Sucak GT,Turgut M,Aksu S,Yagci M,Sayınalp N,Ozcebe OI,Goker H,Haznedaroglu IC

更新日期：2013-01-01 00:00:00

abstract：:Serum IgG, IgM and IgA were determined in 25 patients with homozygous beta thalassemia and 7 with the trait. The levels were increased in homozygous patients and increased further after splenectomy. Serum opsonic activity against Salmonella typhi and staphylococci was impaired in homozygous patients. Splenectomy cause...

journal_title：Acta haematologica

authors： Khalifa AS,Fattah SA,Maged Z,Sabry F,Mohamed HA

更新日期：1983-01-01 00:00:00

abstract：:To clarify the role of thrombopoietin (c-Mpl ligand, TPO) in 'hypersplenic' thrombocytopenia, we used an enzyme-linked immunosorbent assay to examine changes in serum TPO levels accompanied with splenectomy in 6 patients with liver cirrhosis, 4 patients with gastric cancer, and 2 patients with lymphoid malignancies. W...

journal_title：Acta haematologica

authors： Ichikawa N,Kitano K,Shimodaira S,Ishida F,Ito T,Kajikawa S,Tahara T,Kato T,Kiyosawa K

更新日期：1998-12-01 00:00:00