Hyper-CVAD regimen in routine management of adult acute lymphoblastic leukemia: a retrospective multicenter study.

abstract：:Richter syndrome (RS) describes the development of high-grade non-Hodgkin's lymphoma (NHL) from low-grade NHL. RS isolated to the brain is very rare and has a poor prognosis. We describe the cases of high-grade large B-cell diffuse NHL in a 56-year-old male with chronic lymphocytic leukemia and in a 71-year-old female...

journal_title：Acta haematologica

authors： Stuplich M,Mayer K,Kim Y,Thanendrarajan S,Simon M,Schäfer N,Glas M,Schmidt-Wolf IG,Herrlinger U

更新日期：2012-01-01 00:00:00

abstract：:A 69-year-old woman with typical thrombotic thrombocytopenic purpura is reported, who was treated successfully by plasma exchange. An initial chromosomal analysis of peripheral blood lymphocytes revealed abnormal patterns of 45, XO/46, XX/47, XXX; a second analysis showed 45, XO/46, XX/47, XXX/47, XX + 21, and a third...

journal_title：Acta haematologica

authors： Itoh Y,Taniguchi T,Takeyama N,Kuriki H,Tanaka T

更新日期：1990-01-01 00:00:00

abstract：:A comparative study of karyotypes, hematological variables and neutrophil alkaline phosphatase (NAP) was performed in 106 parents (53 couples) of children with free, homogeneous trisomy 21 and of 220 parents (110 couples) of normal children. In the parents of trisomy 21 children we found a significant increase of the ...

journal_title：Acta haematologica

authors： Grozdea J,Bourrouillou G,Mounie C,Colombies P

更新日期：1980-01-01 00:00:00

abstract：:Avascular necrosis (AVN) of the hip is a common cause of morbidity in sickle cell disease (SCD). Its prevalence increases with age and predisposing factors include coexistent alpha-thalassemia trait, frequent vaso-occlusive crisis and a high hematocrit (Hct). SCD is relatively mild among Kuwaiti patients because of th...

journal_title：Acta haematologica

authors： Adekile AD,Gupta R,Yacoub F,Sinan T,Al-Bloushi M,Haider MZ

更新日期：2001-01-01 00:00:00

abstract：:A 29-year-old man with acute myelomonocytic leukemia had an initial leukocyte count of 192 X 10(9) cells/l and 84% blasts. During the initial treatment with hydroxyurea, 1 g/m2 orally tid, he developed pulmonary leukostasis which responded rapidly to whole-lung radiation with 1.5 Gy in one fraction. Pulmonary leukosta...

journal_title：Acta haematologica

authors： von Eyben FE,Siddiqui MZ,Spanos G

更新日期：1987-01-01 00:00:00

abstract：:In 34 patients with chronic lymphatic leukaemia (CLL) the lymphocytes have been separated and sized using a C1000 Channelyzer. The modal volume and the volume range of the populations have been obtained and related to clinical stage and mouse red blood cell (MRBC) rosetting capacity. Over 1 year's observation with sev...

journal_title：Acta haematologica

authors： Wastell HJ,Proctor SJ

更新日期：1983-01-01 00:00:00

abstract：:A patient with acute monoblastic leukemia developed a coagulopathy during chemotherapy. Coagulation studies showed thrombocytopenia, hypofibrinogenemia, high levels of fibrinogen degradation products, a negative protemine test but a normal antithrombin III level. These observations suggest that coagulation abnormaliti...

journal_title：Acta haematologica

authors： Vellenga E,Mulder NH

更新日期：1980-01-01 00:00:00

abstract：:We review the problem of lymphoma classification in the light of the Revised European-American Lymphoma (REAL) scheme, recently proposed by the International Lymphoma Study Group (ILSG). The REAL classification is a list of clinicopathologic entities, all well known from the literature, upon which the ILSG members agr...

journal_title：Acta haematologica

authors： Pileri SA,Ceccarelli C,Sabattini E,Santini D,Leone O,Damiani S,Leoncini L,Falini B

更新日期：1996-01-01 00:00:00

abstract：:The concentration of plasma vitamin B12 bound to transcobalamin II was measured by two methods: QUSO and Heparin Sepharose (HS). The new HS procedure provided a specific, direct measurement of vitamin B12 bound to both R binder and transcobalamin II in plasma. ...

journal_title：Acta haematologica

authors： Benhayoun S,Adjalla C,Nicolas JP,Guéant JL,Lambert D

更新日期：1993-01-01 00:00:00

abstract：:In the last 18 years, we have observed 24 cases of hypoparathyroidism (HPT) in beta-thalassemia major. At present, 4.5% of patients followed regularly in our department have this complication. HPT is thought to be mainly the consequence of iron deposition in the parathyroid glands. The age of our patients when HPT was...

journal_title：Acta haematologica

authors： De Sanctis V,Vullo C,Bagni B,Chiccoli L

更新日期：1992-01-01 00:00:00

abstract：:During a screening for hemoglobinopathies, we found a carrier of the Sardinian δβ-thalassemia condition. The proband's hematology and hemoglobin (Hb) profile agreed with those of the other carriers previously identified during our diagnostic program except for the fetal Hb (HbF) composition, which consisted of both α2...

journal_title：Acta haematologica

authors： Trova S,Mereu P,Cocco E,Masala B,Manca L,Pirastru M

更新日期：2016-01-01 00:00:00

abstract：:Increased levels of hemoglobin A(2) (HbA(2)) are present in most beta-thalassemia carriers. The mechanism of this effect is not understood, although the increase may result from transcriptional and posttranscriptional changes. In the present study, we quantitate delta-globin mRNA levels in peripheral-blood-enriched re...

journal_title：Acta haematologica

authors： Huang SZ,Zeng FY,Chen MJ,Ren ZR,Shen M,Rodgers GP,Schechter AN,Zeng YT

更新日期：1999-01-01 00:00:00

abstract：:The effect of methylprednisolone on fresh cells from patients with chronic lymphocytic leukaemia (CLL) has been studied using the differential staining cytotoxicity (DiSC) assay resulting in LC90s of < or = 0.2 to 2,000 micrograms/ml. Cells from previously treated patients were, on average, significantly more sensitiv...

journal_title：Acta haematologica

authors： Bosanquet AG,McCann SR,Crotty GM,Mills MJ,Catovsky D

更新日期：1995-01-01 00:00:00

abstract：:Platelet aggregation induced in vitro with ADP, adrenalin and ristocetin was tested in 7 patients with megakaryoblastic leukemia (MKL). All patients had normal or high platelet counts and presented with hemorrhagic diathesis including purpura ecchymosis and epistaxis. Platelet morphology was grossly abnormal and elect...

journal_title：Acta haematologica

authors： Berrebi A,Vorst E,Shtalrid M,Resnitzky P,Nir E

更新日期：1984-01-01 00:00:00

abstract：:Electron-microscopic examination of peripheral blood from a patient with 'hairy cell' leukemia revealed classical 'hairy cells', atypical lymphoid cells and numerous pathological plasma cells. Osmiophilic granular material coated the cell surface of 'hairy cells' and lymphoid cells but not the plasmalemma of the plasm...

journal_title：Acta haematologica

authors： Pedio G,Rüttner JR,Spycher MA,Gut D

更新日期：1975-01-01 00:00:00

abstract：:Malaria parasites growing inside human erythrocytes differ from mammalian cells in their mode of acquisition of bioavailable iron and in their susceptibility to the antiproliferative action of iron chelators. We have assessed here three major properties associated with these phenomena: (a) the stage-dependent nature o...

journal_title：Acta haematologica

authors： Cabantchik ZI,Glickstein H,Golenser J,Loyevsky M,Tsafack A

更新日期：1996-01-01 00:00:00

abstract：:Patients with HIV-associated lymphocyte-depleted Hodgkin lymphoma (HIV-HL) often present with advanced, extranodal disease and aggressive clinical features, limiting definitive therapeutic intervention. Here we report two patients with HIV-HL who presented with multi-organ dysfunction as an initial manifestation of th...

journal_title：Acta haematologica

authors： Ding J,Kumar AJ,Wilding E,Lee ST,Law JY

更新日期：2020-01-01 00:00:00

abstract：:Macrothrombocytopenia (MTP) is a group of rare disorders characterized by giant platelets, thrombocytopenia, and variable association with abnormal bleeding. Inherited MTP are frequently misdiagnosed as immune thrombocytopenia. Associated second-organ manifestation can help narrow down syndromic MTPs. We describe a ca...

journal_title：Acta haematologica

authors： Karki NR,Ajebo G,Savage N,Kutlar A

更新日期：2021-01-01 00:00:00

abstract：:There have been many reports of patients with ampulla cardiomyopathy described as takotsubo-shaped cardiomyopathy in the cardiovascular field. This unique cardiomyopathy is characterized by transient apical ballooning and hypokinesis of the left ventricle. We describe 2 cases of ampulla cardiomyopathy associated with ...

journal_title：Acta haematologica

authors： Takeoka Y,Nakamae M,Nakamae H,Hagihara K,Sakamoto E,Nakane T,Koh H,Koh KR,Ohta K,Yamane T,Hino M

更新日期：2007-01-01 00:00:00

abstract：:A 13-year-old Saudi girl presented with severe clinical features of systemic lupus erythematosus of 3 months' duration. In addition to laboratory evidence of the disease, the patient was found to have pancytopenia and myelofibrosis. While pancytopenia was considerably improved by steroids, myelofibrosis was not revers...

journal_title：Acta haematologica

authors： el Mouzan MI,Ahmad MA,al Fadel Saleh M,al Sohaibani MO,al Gindan YM

更新日期：1988-01-01 00:00:00

abstract：:Haemoglobin synthesis was studied in bone marrow erythroblasts and in reticulocytes of 4 children with beta O-thalassaemia major and of 7 children with beta +-thalassaemia major. In patients with beta O-thalassaemia the gamma/a ratio was found to be lower in bone marrow than in peripheral blood. On the contrary, in pa...

journal_title：Acta haematologica

authors： Musumeci S,Schilirò G,Romeo MA,Pizzarelli G,Fischer A,Russo G

更新日期：1981-01-01 00:00:00

abstract：:Agranulocytosis developed in a 20-year-old Greek patient with beta-thalassaemia major, 11 weeks after commencing chelation with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) and 6 weeks after receiving the drug at a total daily dose of 105 mg/kg. The patient presented with generalised weakness, low-gra...

journal_title：Acta haematologica

authors： al-Refaie FN,Veys PA,Wilkes S,Wonke B,Hoffbrand AV

更新日期：1993-01-01 00:00:00

abstract：:Two human stromal cell lines were established previously from bone marrow-derived primary long-term cultures by immortalization using the SV40 large T antigen and cellular cloning. After irradiation, the fibroblast-like cell lines L87/4 and L88/5 support hematopoietic differentiation of allogeneic cord blood cells in ...

journal_title：Acta haematologica

authors： Thalmeier K,Meissner P,Moosmann S,Sagebiel S,Wiest I,Huss R

更新日期：2001-01-01 00:00:00

abstract：:Serum folate levels and unsaturated folate-binding capacity (UFBC) in a mixed population of outpatients and inpatients were analyzed with respect to race, sex, and age. The results supported the relatively high prevalence of subnormal serum folates in patient populations, did not find lower serum folates in the elderl...

journal_title：Acta haematologica

authors： Lawrence VA

更新日期：1983-01-01 00:00:00

abstract：:Marginal-zone B cells of the mucosa-associated lymphoid tissue (MALT) are the normal counterpart of the neoplastic cells in MALT lymphoma. In both cases these lymphocytes express surface immunoglobulins, but are negative when stained for B cell associated antigens like CD10 and CD23. Furthermore, the B cell gene rearr...

journal_title：Acta haematologica

authors： Fritscher-Ravens A,Petrasch S,Tiemann M,Wacker H,Dörr T,Kemmeries G,Hilgers W,Reinacher-Schick A,Kunstmann E,Schmiegel W

更新日期：1999-01-01 00:00:00

abstract：:Fibroblast-like cells were grown from the bone marrow of acute lymphoblastic leukemia (ALL) patients before, during and off therapy. A diminished growth capacity was observed in cells from patients before and during therapy. In the three groups studied, differences were also observed in the effect of hydrocortisone on...

journal_title：Acta haematologica

authors： Bruzzone MS,Minguell JJ

更新日期：1985-01-01 00:00:00

abstract：:Two patients with paraneoplastic cerebellar degeneration accompanying Hodgkin's disease were treated with plasma exchange in combination with chemotherapy or radiation therapy, respectively. Significant improvement in neurologic symptoms was obtained in 1 of them. ...

journal_title：Acta haematologica

authors： Cehreli C,Payzin B,Undar B,Yilmaz U,Alakavuklar MN

更新日期：1995-01-01 00:00:00

abstract：:The activity of ten red blood cell enzymes, including hexokinase, has been measured in 6 Fanconi's anemia patients. In disagreement with previous reports, in no instance were reduced or increased hexokinase levels found. Furthermore, the hexokinase isozymic pattern, thermostability, pH dependence of activity and kinet...

journal_title：Acta haematologica

authors： Magnani M,Novelli G,Stocchi V,Alimena G,Dallapiccola B

更新日期：1984-01-01 00:00:00

abstract：:Iron overload due to regular transfusions of packed red cells can cause multiple organ damage. Iron chelation therapy (ICT) is important in patients with aplastic anemia (AA) who require blood transfusions as supportive management. With the introduction of the oral iron chelator deferasirox, ICT has become more widely...

journal_title：Acta haematologica

authors： Lee SE,Yahng SA,Cho BS,Eom KS,Kim YJ,Lee S,Min CK,Kim HJ,Cho SG,Kim DW,Min WS,Park CW,Lee JW

更新日期：2013-01-01 00:00:00

abstract：:We have retrospectively analyzed a series of 19 patients with hepatitis C virus (HCV) infection and chronic thrombocytopenia not attributable to hypersplenism or to other causes. Antiplatelet antibodies were present in 81% of cases. Response to prednisone was observed in 6 of 7 patients and 1 of 3 patients responded t...

journal_title：Acta haematologica

authors： Hernández F,Blanquer A,Linares M,López A,Tarín F,Cerveró A

更新日期：1998-01-01 00:00:00