Chronic inflammatory bowel disease, deep-venous thrombosis and antithrombin activity.

Abstract:

:Of 34 patients with chronic inflammatory bowel disease (CIBD), 4 developed well-documented episodes of deep-venous thrombosis. All 4 patients had active disease at the time of thrombosis. This group was studied to determine if the tendency to deep-venous thrombosis in patients with CIBD was associated with reduced antithrombin activity by measuring the concentration of three thrombin inhibitors, antithrombin III (AT III), alpha 2-macroglobulin (alpha 2 M) and alpha 1-antitrypsin. 2 patients had low AT III levels and 10 had low alpha 2 M levels. 2 patients who developed deep-venous thrombosis had significantly low levels of both AT III and alpha 2 M. It is suggested that in patients with diseases predisposing to thrombosis and associated with low AT III levels, the measurement of alpha 2 M in addition to AT III may predict those particularly at risk.

journal_name

Acta Haematol

journal_title

Acta haematologica

authors

Ghosh S,Mackie MJ,McVerry BA,Galloway M,Ellis A,McKay J

doi

10.1159/000206688

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

50-3

issue

1

eissn

0001-5792

issn

1421-9662

journal_volume

70

pub_type

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