Effect of L-asparaginase combined with vincristine and prednisolone on acute myeloblastic leukemia (M0) associated with non-Hodgkin lymphoma.

Abstract:

:A 66-year-old Japanese woman was referred to us because of severe anemia and fever and presented at our hospital. She was eventually diagnosed as having acute myeloblastic leukemia (AML; M0) with non-Hodgkin lymphoma (NHL). We investigated the therapeutic efficacy of L-asparaginase (L-Asp), vincristine and prednisolone for both her AML and NHL. Asparagine synthetase (AS) activity in her AML blast cells was undetectable. A lymph node biopsy specimen revealed NHL of the marginal zone B cell type. Complete remission (CR) of AML and NHL was achieved. CR of the AML lasted for 18 months without further consolidation therapy. We conclude that L-Asp can be an effective drug for the treatment of AML in which blasts are negative for AS.

journal_name

Acta Haematol

journal_title

Acta haematologica

authors

Horikoshi A,Takei K,Iriyama N,Uenogawa K,Ishizuka H,Shiraiwa H,Hosokawa Y,Sawada S,Kitoh T

doi

10.1159/000243725

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

54-7

issue

1

eissn

0001-5792

issn

1421-9662

pii

000243725

journal_volume

122

pub_type

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