Evaluation of capillary collection system for HbA1c specimens.

Abstract:

OBJECTIVE:We evaluated the accuracy and stability of a capillary HbA1c collection system for use with a high-performance liquid chromatography analyzer. RESEARCH DESIGN AND METHODS:The collection system requires that 5 ul blood is drawn into a calibrated capillary tube, which is then placed into a vial of stabilizing solution and sent for analysis. The study was conducted on simultaneously drawn capillary and venous blood specimens from 47 pediatric diabetes patients. Accuracy was determined by comparing the capillary to the venous HbA1c values. Stability was measured by analyzing 17 capillary specimens over 3 wk. RESULTS:There was excellent agreement between the capillary and venous HbA1c values (capillary 0.959, venous +0.494, R2 = 98.7%). The capillary HbA1c values were 0.2% higher than the venous HbA1c values and decreased gradually over time (0.1% HbA1c/week) when stored at room temperature. CONCLUSIONS:The Bio-Rad (Richmond, CA) collection system is accurate, stable, and simple to use.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Voss EM,Cembrowski GS,Clasen BL,Spencer ML,Ainslie MB,Haig B

doi

10.2337/diacare.15.5.700

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

700-1

issue

5

eissn

0149-5992

issn

1935-5548

journal_volume

15

pub_type

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