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Synthesis and antiinflammatory activity of heterocyclic indole derivatives.

Abstract：

:Chalcones of indole 1-5 and their corresponding products; pyrazolines 6-10 and azo compounds 11-15 were synthesised and evaluated for their antiinflammatory activity against carrageenan induced oedema in albino rats at a dose of 50 mg x kg(-1) oral. The structure of compounds was confirmed by IR, (1)H-NMR and mass spectral data. All the compounds of this series showed promising antiinflammatory activity. The most active compound of this series is 3-[1-acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl]indole (7) was found to be most potent, which has shown higher percent of inhibition of oedema, lower ulcerogenic liability and acute toxicity than the standard drug phenylbutazone.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Rani P,Srivastava VK,Kumar A

doi

10.1016/j.ejmech.2003.11.002

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

449-52

issue

5

eissn

0223-5234

issn

1768-3254

pii

S0223523403002198

journal_volume

39

pub_type

杂志文章

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