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Synthesis, characterization and anticancer screening of some novel piperonyl-tetrazole derivatives.

Abstract：

:A series of new 1,2-substituted tetrazole derivatives were synthesized and evaluated on MCF-7 (ER positive), MDA-MB-231 and ZR-75 (ER negative) breast cancer cell lines. Out of the fourteen compounds, three compounds 10, 12 and 14 showed higher inhibitory effects on MCF-7 cells. Whereas, compound 8 exhibited higher inhibition in MDA-MB-231 and ZR-75 cells at 10(-5) M concentration. Total RNA was extracted and effect of compounds on different marker genes was studied. The gene expression of CD44, BRAC and BAX were significantly affected. The compounds were screened against the HepG2 cell line, to know if they are selectively targeting specific cancers and only 1-10 percent inhibition was found at 10(-5) M concentration.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Arshad M,Bhat AR,Pokharel S,Kim JE,Lee EJ,Athar F,Choi I

doi

10.1016/j.ejmech.2013.11.008

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

229-36

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(13)00742-3

journal_volume

71

pub_type

杂志文章

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