当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Preparation of 4-azaindole and 7-azaindole dimers with a bisalkoxyalkyl spacer in order to preferentially target melatonin MT1 receptors over melatonin MT2 receptors.

Preparation of 4-azaindole and 7-azaindole dimers with a bisalkoxyalkyl spacer in order to preferentially target melatonin MT1 receptors over melatonin MT2 receptors.

Abstract：

:Several 4-azaindole and 7-azaindole dimer analogues of melatonin with a bisalkoxyalkyl spacer between the position 5 of each heterocycle were synthetized. Our aim was to investigate the influence of the spacers length on the selectivity of such compounds for the MT(1) receptors over the MT(2) receptors. Our results suggest the distance between indole ring seems to be an important parameter in determining the potency of binding with melatonin receptor site.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Larraya C,Guillard J,Renard P,Audinot V,Boutin JA,Delagrange P,Bennejean C,Viaud-Massuard MC

doi

10.1016/j.ejmech.2004.03.005

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

515-26

issue

6

eissn

0223-5234

issn

1768-3254

pii

S0223523404000571

journal_volume

39

pub_type

杂志文章

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