Abstract:
:We report herein an efficient enantioselective synthesis of SPF32629A and SPF32629B through one-pot enantioselective reduction and protecting-group-free regioselective O-acylation strategy. The absolute configuration of the enantiomerically pure isomers was established by Mosher ester analysis. The inhibitory potencies of the synthesized compounds were assayed in vitro against a panel of microorganisms and against A549 human lung adenocarcinoma cell line. Compounds 2, 11 and 12 displayed moderate to potent antibacterial activity against all the tested strains and compounds 7, 8, 2, 11 and 12 exhibited significant cytotoxicity in a dose-dependent manner with an IC50 values ranging from 2.92 to 4.14 μg/ml and 8-11 μM.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Vegi SR,Boovanahalli SK,Patro B,Mukkanti Kdoi
10.1016/j.ejmech.2011.02.039subject
Has Abstractpub_date
2011-05-01 00:00:00pages
1803-12issue
5eissn
0223-5234issn
1768-3254pii
S0223-5234(11)00150-4journal_volume
46pub_type
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