SPF32629A and SPF32629B: enantioselective synthesis, determination of absolute configuration, cytotoxicity and antibacterial evaluation.

Abstract:

:We report herein an efficient enantioselective synthesis of SPF32629A and SPF32629B through one-pot enantioselective reduction and protecting-group-free regioselective O-acylation strategy. The absolute configuration of the enantiomerically pure isomers was established by Mosher ester analysis. The inhibitory potencies of the synthesized compounds were assayed in vitro against a panel of microorganisms and against A549 human lung adenocarcinoma cell line. Compounds 2, 11 and 12 displayed moderate to potent antibacterial activity against all the tested strains and compounds 7, 8, 2, 11 and 12 exhibited significant cytotoxicity in a dose-dependent manner with an IC50 values ranging from 2.92 to 4.14 μg/ml and 8-11 μM.

journal_name

Eur J Med Chem

authors

Vegi SR,Boovanahalli SK,Patro B,Mukkanti K

doi

10.1016/j.ejmech.2011.02.039

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

1803-12

issue

5

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(11)00150-4

journal_volume

46

pub_type

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