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Anti-proliferative evaluation of monoterpene derivatives against leukemia.

Abstract：

:The cure rate of pediatric acute lymphoblastic leukemia (ALL) has significantly improved in the past thirty years, however not all patient cohorts respond well to current chemotherapy regimens. Among the high risk patient cohort is infants with MLL-rearranged (MLL-r) B-ALL, which remains dismal with an overall survival rate <35%. Our program is interested in identifying new molecular scaffolds to better understand the underlying mechanisms and ultimately provide new targeted treatments. Based on a phenotypic screen, phenolic natural products were identified as promising scaffolds for further chemical evaluation. Herein we disclose the effects of a potent anti-proliferative compound 31 against human ALL leukemia cellular models.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Gautam LN,Ling T,Lang W,Rivas F

doi

10.1016/j.ejmech.2016.02.034

subject

Has Abstract

pub_date

2016-05-04 00:00:00

pages

75-80

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(16)30114-3

journal_volume

113

pub_type

杂志文章

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