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Synthesis, characterization and anti-proliferative activity of heterocyclic hypervalent organoantimony compounds.

Abstract：

:Three heterocyclic hypervalent organoantimony chlorides RN(CH2C6H4)2SbCl (2a R = t-Bu, 2b R = Cy, 2c R = Ph) and their chalcogenide derivatives [RN(CH2C6H4)2Sb]2O (3a R = t-Bu, 3b R = Cy, 3c R = Ph) were synthesized and characterized by techniques such as (1)H NMR, (13)C NMR, X-ray diffraction, and elemental analysis. It is found that the anti-proliferative activity detected over these compounds can be attributed to the coordination bond between the antimony and nitrogen atoms of these compounds. Moreover, a preliminary study on mechanistic action suggests that the inhibition effect is ascribable to cell cycle arrest and cell apoptosis.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Chen Y,Yu K,Tan NY,Qiu RH,Liu W,Luo NL,Tong L,Au CT,Luo ZQ,Yin SF

doi

10.1016/j.ejmech.2014.04.026

subject

Has Abstract

pub_date

2014-05-22 00:00:00

pages

391-8

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(14)00345-6

journal_volume

79

pub_type

杂志文章

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