当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Caffeoylglycolic and caffeoylamino acid derivatives, halfmers of L-chicoric acid, as new HIV-1 integrase inhibitors.

Caffeoylglycolic and caffeoylamino acid derivatives, halfmers of L-chicoric acid, as new HIV-1 integrase inhibitors.

Abstract：

:Human immunodeficiency virus (HIV) integrase (IN) catalyzes the integration of HIV DNA copy into the host cell DNA. L-Chicoric acid (1) has been found to be one of the most potent HIV-1 integrase inhibitor. Caffeoylglycolic and caffeoylamino acid derivatives' halfmeric structures of L-chicoric acid 2 were synthesized for the purpose of simplifying the structure of L-chicoric acid. Among synthesized, compounds 2c and 3f showed HIV-1 IN inhibitory activities with IC(50) values of 10.5 and 12.0 microM, respectively, comparable to that of parent compound L-chicoric acid (IC(50)=15.7 microM).

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Lee SU,Shin CG,Lee CK,Lee YS

doi

10.1016/j.ejmech.2007.02.016

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

1309-15

issue

10

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(07)00113-4

journal_volume

42

pub_type

杂志文章

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