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Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b]thiazole derivatives.

Abstract：

:A series of arylidenehydrazides (3a-3i) were synthesized from [6-(4-bromophenyl)imidazo[2,1-b]thiazol-3-yl]acetic acid hydrazide. The structures of new compounds were determined by analytical and spectral (IR, (1)H NMR, (13)C NMR, EIMS) methods. The synthesized compounds (3a-3i) were evaluated in the National Cancer Institute's 3-cell line, one dose in vitro primary cytotoxicity assay. Compounds 3a-3c, 3h and 3i which passed the criteria for activity in this assay were scheduled automatically for evaluation against the full panel of 60 human tumour cell lines at a minimum of five concentrations at 10-fold dilutions. Compounds 3c demonstrated the most marked effects on a prostate cancer cell line (PC-3, log(10)GI(50) value<-8.00).

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Gürsoy E,Güzeldemirci NU

doi

10.1016/j.ejmech.2006.10.012

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

320-6

issue

3

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(06)00387-4

journal_volume

42

pub_type

杂志文章

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