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Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity.

Abstract：

:With an intention to synergize the anti-bacterial activity of chalcones and rhodanine-3-acetic acid, several hybrid compounds possessing chalcone and rhodanine-3-acetic acid moieties were synthesized and tested for their anti-bacterial activity. Some compounds presented great anti-microbial activities against Gram-positive bacteria (including the multidrug-resistant clinical isolates). This class of compounds presented high potency against Staphylococcus aureus, among which the derivatives 5k with a MIC of 2 μg/mL was as active as the standard drug (norfloxacin) and less active than oxacillin. Compounds 5a-s did not inhibit the growth of Gram-negative bacteria Escherichia coli CCARM 1924 or E. coli CCARM 1356 at 64 μg/mL.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Chen ZH,Zheng CJ,Sun LP,Piao HR

doi

10.1016/j.ejmech.2010.09.031

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

5739-43

issue

12

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(10)00679-3

journal_volume

45

pub_type

杂志文章

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