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Synthesis, spectroscopic and biological properties of bis(3-arylimidazolidinyl-1)methanes. A novel family of antimicrobial agents.

Abstract：

:Synthesis, spectroscopic and biological properties of new bis(3-arylimidazolidinyl-1)methanes are described. These compounds were synthesized by condensation reaction between N-arylethylenediamines and formaldehyde. Chemical structures were confirmed by means of their (1)H- and (13)C-NMR and mass spectroscopic data. Investigation of in vitro antimicrobial activity was performed using Gram-negative and Gram-positive bacteria as well as antifungal studies against Aspergillus niger and Candida albicans. Minimal inhibitory concentrations of active compounds were determined.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Perillo I,Repetto E,Caterina MC,Massa R,Gutkind G,Salerno A

doi

10.1016/j.ejmech.2005.03.010

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

811-5

issue

8

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(05)00096-6

journal_volume

40

pub_type

杂志文章

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