5-Substituted [1]pyrindine derivatives with antiproliferative activity.

Abstract:

:We report herein the synthesis of 5-substituted [1]pyrindine derivatives and the evaluation of their antiproliferative properties on HeLa cells, a cervical carcinoma tumor cell line, and on the melanoma A2058 cell line. The most efficient compounds display cytotoxicity against tumor cells in the micromolar range but have interestingly no effect against the normal human fibroblasts CRL-2796. Generally, these pyrindines are active on both tumor cell lines. Compounds bearing large substituents with structural rigidity at position 5 such as phenyl-furyl show no inhibition of cell growth.

journal_name

Eur J Med Chem

authors

Kolb S,Goddard ML,Loukaci A,Mondésert O,Ducommun B,Braud E,Garbay C

doi

10.1016/j.ejmech.2009.11.028

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

896-901

issue

3

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(09)00598-4

journal_volume

45

pub_type

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