Abstract:
:We report herein the synthesis of 5-substituted [1]pyrindine derivatives and the evaluation of their antiproliferative properties on HeLa cells, a cervical carcinoma tumor cell line, and on the melanoma A2058 cell line. The most efficient compounds display cytotoxicity against tumor cells in the micromolar range but have interestingly no effect against the normal human fibroblasts CRL-2796. Generally, these pyrindines are active on both tumor cell lines. Compounds bearing large substituents with structural rigidity at position 5 such as phenyl-furyl show no inhibition of cell growth.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Kolb S,Goddard ML,Loukaci A,Mondésert O,Ducommun B,Braud E,Garbay Cdoi
10.1016/j.ejmech.2009.11.028subject
Has Abstractpub_date
2010-03-01 00:00:00pages
896-901issue
3eissn
0223-5234issn
1768-3254pii
S0223-5234(09)00598-4journal_volume
45pub_type
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