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Synthesis of 3-((2,4-dichlorophenoxy)methyl)-1,2,4-triazolo(thiadiazoles and thiadiazines) as anti-inflammatory and molluscicidal agents.

Abstract：

:A series of fused and non fused 1,2,4-triazoles with (2,4-dichlorophenoxy) moiety are prepared utilizing 3-((2,4-dichlorophenoxy)methyl)-4-amino-4H-1,2,4-triazole-5-thiol (3). The latter on reaction with carboxylic acids, ethylchloroformate, ethylcyanoacetate and sodium nitrite gives five membered fused triazole derivatives 4a-d, 5, 6, 7 and 10, respectively. The six membered heterocycles 11, 12 and 14 are prepared by cyclization of compound 3 with phenacyl bromide, chloroacetic acid and alpha-bromoketone respectively. Most of the newly synthesized compounds were screened for their anti-inflammatory and molluscicidal activities. The compounds 4b, 4d, 11 and 14 showed potent anti-inflammatory activities in dose dependent manner while compounds 3, 4b, 8 and 10 exhibited promising molluscicidal activities.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

El Shehry MF,Abu-Hashem AA,El-Telbani EM

doi

10.1016/j.ejmech.2010.01.030

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

1906-11

issue

5

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(10)00075-9

journal_volume

45

pub_type

杂志文章

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