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Novel benzopsoralen analogues: synthesis, biological activity and molecular docking studies.

Abstract：

:New benzopsoralen analogues were synthesized and their inhibitory effect on the growth of tumourtumour cell lines (MDA MB231 and TCC-SUP) was evaluated. The in vitro antitumour activity of the new benzopsoralen analogues was discussed in terms of structure-activity relationship. Molecular docking studies with human-CYP2A6 enzymes were also carried out with the synthesized compounds to evaluate the potential of these molecules to interact with the haem group of the enzymes. The results demonstrated that the compounds that are able to interact with the iron ion of the haem cofactor and at the same time with active site Asn297 are those that have better anti-proliferative activity.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Francisco CS,Rodrigues LR,Cerqueira NM,Oliveira-Campos AM,Esteves AP

doi

10.1016/j.ejmech.2014.09.066

subject

Has Abstract

pub_date

2014-11-24 00:00:00

pages

298-305

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(14)00885-X

journal_volume

87

pub_type

杂志文章

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